Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Scott A. Hahn"'
Autor:
Evan R. DeVallance, Heidi M. Schmidt, Madison Seman, Sara E. Lewis, Katherine C. Wood, Schuyler D. Vickers, Scott A. Hahn, Murugesan Velayutham, Emily A. Hileman, Dario A. Vitturi, Roberta Leonardi, Adam C. Straub, Eric E. Kelley
Publikováno v:
Redox Biology, Vol 67, Iss , Pp 102866- (2023)
We recently reported a previously unknown salutary role for xanthine oxidoreductase (XOR) in intravascular heme overload whereby hepatocellular export of XOR to the circulation was identified as a seminal step in affording protection. However, the ce
Externí odkaz:
https://doaj.org/article/87ca64a023a542648045412108a3db24
Autor:
Heidi M. Schmidt, Evan R. DeVallance, Sara E. Lewis, Katherine C. Wood, Gowtham K. Annarapu, Mara Carreño, Scott A. Hahn, Madison Seman, Brooke A. Maxwell, Emily A. Hileman, Julia Z. Xu, Murugesan Velayutham, Werner J. Geldenhuys, Dario A. Vitturi, Sruti Shiva, Eric E. Kelley, Adam C. Straub
Publikováno v:
Redox Biology, Vol 62, Iss , Pp 102636- (2023)
Xanthine oxidase (XO) catalyzes the catabolism of hypoxanthine to xanthine and xanthine to uric acid, generating oxidants as a byproduct. Importantly, XO activity is elevated in numerous hemolytic conditions including sickle cell disease (SCD); howev
Externí odkaz:
https://doaj.org/article/fc1d13f5ed7a4f76bf1f12017427f9c4
Autor:
Marta Bueno, Jazmin Calyeca, Timur Khaliullin, Megan P. Miller, Diana Alvarez, Lorena Rosas, Judith Brands, Christian Baker, Amro Nasser, Stephanie Shulkowski, August Mathien, Nneoma Uzoukwu, John Sembrat, Brenton G. Mays, Kaitlin Fiedler, Scott A. Hahn, Sonia R. Salvatore, Francisco J. Schopfer, Mauricio Rojas, Peter Sandner, Adam C. Straub, Ana L. Mora
Publikováno v:
JCI Insight, Vol 8, Iss 5 (2023)
Type II alveolar epithelial cell (AECII) redox imbalance contributes to the pathogenesis of idiopathic pulmonary fibrosis (IPF), a deadly disease with limited treatment options. Here, we show that expression of membrane-bound cytochrome B5 reductase
Externí odkaz:
https://doaj.org/article/c430eef5b8e94876abbd6d496306422d
Autor:
Nolan T. Carew, Heidi M. Schmidt, Shuai Yuan, Joseph C. Galley, Robert Hall, Helene M. Altmann, Scott A. Hahn, Megan P. Miller, Katherine C. Wood, Bethann Gabris, Margaret C. Stapleton, Sean Hartwick, Marco Fazzari, Yijen L. Wu, Mohamed Trebak, Brett A. Kaufman, Charles F. McTiernan, Francisco J. Schopfer, Placido Navas, Patrick H. Thibodeau, Dennis M. McNamara, Guy Salama, Adam C. Straub
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 18 (2022)
Sudden cardiac death (SCD) in patients with heart failure (HF) is allied with an imbalance in reduction and oxidation (redox) signaling in cardiomyocytes; however, the basic pathways and mechanisms governing redox homeostasis in cardiomyocytes are no
Externí odkaz:
https://doaj.org/article/347f7b78e498476bb1cd8f897c890698
Autor:
Shuai Yuan, Scott A. Hahn, Megan P. Miller, Subramaniam Sanker, Michael J. Calderon, Mara Sullivan, Atinuke M. Dosunmu-Ogunbi, Marco Fazzari, Yao Li, Michael Reynolds, Katherine C. Wood, Claudette M. St Croix, Donna Stolz, Eugenia Cifuentes-Pagano, Placido Navas, Sruti Shiva, Francisco J. Schopfer, Patrick J. Pagano, Adam C. Straub
Publikováno v:
Redox Biology, Vol 47, Iss , Pp 102166- (2021)
NADPH oxidase 4 (NOX4) regulates endothelial inflammation by producing hydrogen peroxide (H2O2) and to a lesser extent O2•-. The ratio of NOX4-derived H2O2 and O2•- can be altered by coenzyme Q (CoQ) mimics. Therefore, we hypothesize that cytochr
Externí odkaz:
https://doaj.org/article/8dc1b93959bb456aae238a06ad89c79a
Autor:
Scott A. Hahn, Ying Tang, Mark T. Gladwin, Taijyu Satoh, Charles F. McTiernan, Kentaro Noda, Cynthia St. Hilaire, Bing Wang, Adam C. Straub, Samuel K. Wyman, Cristina Espinosa-Diez, Georgios Triantafyllou, Jeffrey J. Baust, Sruti Shiva, Matthew R Dent, Longfei Wang, Yijen L. Wu, Elena A. Goncharova, Dmitry A. Goncharov, Mike Reynolds, Yen Chun Lai, Andrea R. Levine, Elizabeth R. Rochon, Delphine Gomez, Stephen Y. Chan
Publikováno v:
Circulation
Circulation, vol 144, iss 8
Circulation, vol 144, iss 8
Background: Many patients with heart failure with preserved ejection fraction have metabolic syndrome and develop exercise-induced pulmonary hypertension (EIPH). Increases in pulmonary vascular resistance in patients with heart failure with preserved
Autor:
Scott A. Hahn, Joseph C Galley, Brittany G Durgin, Sean D. Stocker, Edwin K. Jackson, Megan P. Miller, Adam C. Straub
Publikováno v:
British Journal of Pharmacology. 179:2490-2504
Background and purpose Reduced renal blood flow triggers activation of the renin-angiotensin-aldosterone system (RAAS) leading to renovascular hypertension. Renal vascular smooth muscle expression of the NO receptor, soluble GC (sGC), modulates the v
Autor:
Adam C. Straub, Jianhai Du, Samit Ghosh, Heidi M Schmidt, Brenda McMahon, Jeffrey D. Lebensburger, Solomon F. Ofori-Acquah, Scott A. Hahn, Yekai Wang, Joo-Yeun Oh, Shuai Yuan, Katherine C. Wood, Jeffrey J. Baust, Sara E. Lewis, Dario A. Vitturi, Eric E. Kelley, Timothy N. Bachman, Rakesh P. Patel, Xena M. Williams
Publikováno v:
Arterioscler Thromb Vasc Biol
Objective: Chronic hemolysis is a hallmark of sickle cell disease (SCD) and a driver of vasculopathy; however, the mechanisms contributing to hemolysis remain incompletely understood. Although XO (xanthine oxidase) activity has been shown to be eleva
Autor:
Scott A. Hahn, Pedro Lourenço Katayama, Leon J. DeLalio, Sean D. Stocker, Adam C. Straub, William B. Farquhar, Megan M. Wenner
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology
Renovascular hypertension is characterized by activation of the renin-angiotensin-aldosterone system, blunted natriuretic responses, and elevated sympathetic nerve activity. Excess dietary salt intake exaggerates arterial blood pressure (ABP) in mult
Autor:
Brenda McMahon, Jeffrey J. Baust, Brittany G Durgin, Adam C. Straub, Katherine C. Wood, Scott A. Hahn
Publikováno v:
J Mol Cell Cardiol
Chronic hypoxia is a major driver of cardiovascular complications, including heart failure. The nitric oxide (NO) – soluble guanylyl cyclase (sGC) – cyclic guanosine monophosphate (cGMP) pathway is integral to vascular tone maintenance. Specifica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9664ddf45cb7e5cc4811d3ad50b402d5
https://europepmc.org/articles/PMC8766905/
https://europepmc.org/articles/PMC8766905/