Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Scott A. Detmer"'
Autor:
Susan K. Lyman, Suzanne C. Crawley, Ruoyu Gong, Joanne I. Adamkewicz, Garth McGrath, Jason Y. Chew, Jennifer Choi, Charles R. Holst, Leanne H. Goon, Scott A. Detmer, Jana Vaclavikova, Mary E. Gerritsen, Robert A. Blake
Publikováno v:
PLoS ONE, Vol 6, Iss 3 (2011)
Externí odkaz:
https://doaj.org/article/2f45722322f6416e9d86caf0046a9f63
Autor:
Susan K Lyman, Suzanne C Crawley, Ruoyu Gong, Joanne I Adamkewicz, Garth McGrath, Jason Y Chew, Jennifer Choi, Charles R Holst, Leanne H Goon, Scott A Detmer, Jana Vaclavikova, Mary E Gerritsen, Robert A Blake
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e17692 (2011)
BackgroundMany proteins that are dysregulated or mutated in cancer cells rely on the molecular chaperone HSP90 for their proper folding and activity, which has led to considerable interest in HSP90 as a cancer drug target. The diverse array of HSP90
Externí odkaz:
https://doaj.org/article/f3255661be8a49999d93ff431dca0903
Autor:
David C. Chan, Scott A. Detmer
Publikováno v:
Nature Reviews Molecular Cell Biology. 8:870-879
Recent findings have sparked renewed appreciation for the remarkably dynamic nature of mitochondria. These organelles constantly fuse and divide, and are actively transported to specific subcellular locations. These dynamic processes are essential fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b371d1595a791a576ff9f795b6b15b2b
https://doi.org/10.1038/nrm2275
https://doi.org/10.1038/nrm2275
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1763(5-6):482-489
Mitochondrial fusion requires coordinated fusion of the outer and inner membranes. This process leads to exchange of contents, controls the shape of mitochondria, and is important for mitochondrial function. Two types of mitochondrial GTPases are ess
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a781e288cddec830e127ee829788ee5
Autor:
Scott E. Fraser, David C. Chan, Erik E. Griffin, Hsiuchen Chen, Andrew J. Ewald, Scott A. Detmer
Publikováno v:
The Journal of Cell Biology
Mitochondrial morphology is determined by a dynamic equilibrium between organelle fusion and fission, but the significance of these processes in vertebrates is unknown. The mitofusins, Mfn1 and Mfn2, have been shown to affect mitochondrial morphology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e48de66099004d29e1db2842b6f2374b
https://doi.org/10.1083/jcb.200211046
https://doi.org/10.1083/jcb.200211046
Autor:
Leanne H. Goon, Suzanne C. Crawley, Jana Vaclavikova, Joanne I. Adamkewicz, Garth Joseph Mcgrath, Scott A. Detmer, Robert A. Blake, Jason Y. Chew, Jennifer Choi, Susan K. Lyman, Mary E. Gerritsen, Ruoyu Gong, Charles R. Holst
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e17692 (2011)
PLoS ONE
PLoS ONE
BackgroundMany proteins that are dysregulated or mutated in cancer cells rely on the molecular chaperone HSP90 for their proper folding and activity, which has led to considerable interest in HSP90 as a cancer drug target. The diverse array of HSP90
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1429f7929e153bcbf9fc02535487eba
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21408192/?tool=EBI
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21408192/?tool=EBI
Publikováno v:
Human molecular genetics. 17(3)
Charcot–Marie–Tooth (CMT) disease type 2A is a progressive, neurodegenerative disorder affecting long peripheral motor and sensory nerves. The most common clinical sign is weakness in the lower legs and feet, associated with muscle atrophy and ga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2db67d02c438da8e068dd20c620ab0a9
https://pubmed.ncbi.nlm.nih.gov/17959936
https://pubmed.ncbi.nlm.nih.gov/17959936
Publikováno v:
The FASEB Journal. 21
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::081f52e9e5823a3ee5ce5c432ce162e3
https://doi.org/10.1096/fasebj.21.5.a96-b
https://doi.org/10.1096/fasebj.21.5.a96-b
Autor:
Scott A. Detmer, David C. Chan
Publikováno v:
The Journal of Cell Biology
Mfn2, an oligomeric mitochondrial protein important for mitochondrial fusion, is mutated in Charcot-Marie-Tooth disease (CMT) type 2A, a peripheral neuropathy characterized by axonal degeneration. In addition to homooligomeric complexes, Mfn2 also as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f15dfc3f2960c80a7ea09dc6f57f185
https://resolver.caltech.edu/CaltechAUTHORS:DETjcb07
https://resolver.caltech.edu/CaltechAUTHORS:DETjcb07
Autor:
David C. Chan, Takumi Koshiba, Jens T. Kaiser, Scott A. Detmer, Hsiuchen Chen, J. Michael McCaffery
Publikováno v:
Science (New York, N.Y.). 305(5685)
Vesicle fusion involves vesicle tethering, docking, and membrane merger. We show that mitofusin, an integral mitochondrial membrane protein, is required on adjacent mitochondria to mediate fusion, which indicates that mitofusin complexes act in trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c285df66d00e4ed258283f792acccb0
https://pubmed.ncbi.nlm.nih.gov/15297672
https://pubmed.ncbi.nlm.nih.gov/15297672