Výsledky vyhledávání - "Scott A. Coats"

The Neurosecretory Vesicle Protein Phogrin Functions as a Phosphatidylinositol Phosphatase to Regulate Insulin Secretion

Autor: Leslie A. Caromile, Scott A. Coats, Anush Oganesian, Ronald A. Seifert, Daniel F. Bowen-Pope

Publikováno v: Journal of Biological Chemistry. 285:10487-10496

Phogrin is a transmembrane protein expressed in cells with stimulus-coupled peptide hormone secretion, including pancreatic beta cells, in which it is localized to the membrane of insulin-containing dense-core vesicles. By sequence, phogrin is a memb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56f76c5a41a5031081249e8d644b6381
https://doi.org/10.1074/jbc.m109.066563

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Mitotic spindle destabilization and genomic instability in Shwachman-Diamond syndrome

Autor: Karyn M. Austin, Gustavo Mostoslavsky, David Pellman, Richard C. Mulligan, Alejandro B. Balazs, Akiko Shimamura, Asmin Tulpule, George Q. Daley, Mohan L. Gupta, Scott A. Coats

Publikováno v: Journal of Clinical Investigation. 118:1511-1518

Deficiencies in the SBDS gene result in Shwachman-Diamond syndrome (SDS), an inherited bone marrow failure syndrome associated with leukemia predisposition. SBDS encodes a highly conserved protein previously implicated in ribosome biogenesis. Using h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::943e87ff37ba57b761745d63855ee63d
https://doi.org/10.1172/jci33764

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Vasodilator-Stimulated Phosphoprotein Regulates Proliferation and Growth Inhibition by Nitric Oxide in Vascular Smooth Muscle Cells

Autor: Kanchan Chitaley, Lihua Chen, Günter Daum, Martin Eigenthaler, Ulrich Walter, Alexander W. Clowes, Naresh R. Thumati, Daniel F. Bowen-Pope, Scott A. Coats

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology. 24:1403-1408

Objective— Vasodilator-stimulated phosphoprotein (VASP) was identified as a substrate for cGMP-dependent protein kinase (PKG) and cAMP-dependent protein kinase (PKA). It is preferentially phosphorylated at serine239 by PKG, whereas serine157 is a p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93f651e075447c4d2ace32185c10eaab
https://doi.org/10.1161/01.atv.0000134705.39654.53

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ADAM15 Overexpression in NIH3T3 Cells Enhances Cell–Cell Interactions

Autor: Kyle J. Garton, Elaine W. Raines, Russell Ross, Daniel F. Bowen-Pope, Scott A. Coats, Barbara Herren

Publikováno v: Experimental Cell Research. 271:152-160

ADAM15 is a member of the family of metalloprotease-disintegrins that have been shown to interact with integrins in an RGD- and non-RGD-dependent manner. In the present study, we examined the effects of ADAM15 overexpression on cell-matrix and cell-c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4b11552d7b59b74912a22b483382d40
https://doi.org/10.1006/excr.2001.5353

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Matrix Metalloproteinase-9 Overexpression Enhances Vascular Smooth Muscle Cell Migration and Alters Remodeling in the Injured Rat Carotid Artery

Autor: Richard D. Kenagy, David Hasenstab, Ronald A. Seifert, David P. Mason, Suzanne Hawkins, Scott A. Coats, Alexander W. Clowes, Daniel F. Bowen-Pope

Publikováno v: Circulation Research. 85:1179-1185

Abstract —Matrix metalloproteinase-9 (MMP-9) has been implicated in the pathogenesis of atherosclerosis as well as intimal hyperplasia after vascular injury. We used Fischer rat smooth muscle cells (SMCs) overexpressing MMP-9 to determine the role

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6b9035922c560c9d21c187aee1e0d0c
https://doi.org/10.1161/01.res.85.12.1179

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Platelet-derived growth factor (PDGF) receptor alpha-subunit mutant and reconstituted cell lines demonstrate that transforming growth factor-beta can be mitogenic through PDGF A-chain-dependent and -independent pathways

Autor: Daniel F. Bowen-Pope, Russell Ross, Ronald A. Seifert, Scott A. Coats, Elaine W. Raines

Publikováno v: Journal of Biological Chemistry. 269:13951-13955

Mitogenic stimulation of connective tissue cells by transforming growth factor-beta (TGF-beta) has two unusual properties; entry into S-phase is delayed compared with that induced by other mitogens, and the dose response is biphasic, with low concent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::16b93dcb8f948eaf30c153b84a89846a
https://doi.org/10.1016/s0021-9258(17)36740-6

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A receptor-like inositol lipid phosphatase is required for the maturation of developing cochlear hair bundles

Autor: Anush Oganesian, Dan F. Bowen-Pope, M. B. Wright, Guy P. Richardson, Walter Marcotti, Ronald A. Seifert, Scott A. Coats, Richard J. Goodyear, Corné J. Kros, C. J. Booth, P. K. Legan

A screen for protein tyrosine phosphatases (PTPs) expressed in the chick inner ear yielded a high proportion of clones encoding an avian ortholog of protein tyrosine phosphatase receptor Q (Ptprq), a receptor-like PTP. Ptprq was first identified as a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2b42d873dc8dcd2cd942f74948c366f
http://sro.sussex.ac.uk/id/eprint/28442/1/9208.full.pdf

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PTPRQ is a novel phosphatidylinositol phosphatase that can be expressed as a cytoplasmic protein or as a subcellularly localized receptor-like protein

Autor: Anush Oganesian, Charles E. Alpers, Ronald A. Seifert, Scott A. Coats, Richard J. Johnson, Daniel F. Bowen-Pope, M. B. Wright, C. J. Booth, M. Dishmon

Publikováno v: Experimental cell research. 287(2)

PTPRQ (rPTP-GMC1) is a member of the type III receptor-like protein tyrosine phosphatase family. PTPRQ has very low activity against phosphotyrosine but is active against phosphatidylinositol phosphates that are involved in regulation of survival, pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e414569fa7c597f46d13721af4a6304
https://pubmed.ncbi.nlm.nih.gov/12837292

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Fas/FADD-mediated activation of a specific program of inflammatory gene expression in vascular smooth muscle cells

Autor: R K Ramachandran, L D Adams, W C Liles, Ronald A. Seifert, David K. Han, Stephen M. Schwartz, Friedemann J. Schaub, Daniel F. Bowen-Pope, Scott A. Coats

Publikováno v: Nature medicine. 6(7)

Apoptosis of smooth muscle cells is a common feature of vascular lesions but its pathophysiological significance is not known. We demonstrate that signals initiated by regulated Fas-associated death domain protein overexpression in rat vascular smoot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb276f576cc53bf06f43818e432a977b
https://pubmed.ncbi.nlm.nih.gov/10888928

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