Zobrazeno 1 - 10
of 503
pro vyhledávání: '"Scott A. Armstrong"'
Autor:
Nuria Tubío-Santamaría, Ashok Kumar Jayavelu, Tina M. Schnoeder, Theresa Eifert, Chen-Jen Hsu, Florian Perner, Qirui Zhang, Daniela V. Wenge, Fynn M. Hansen, Joanna M. Kirkpatrick, Nidhi Jyotsana, Steven W. Lane, Björn von Eyss, Aniruddha J. Deshpande, Michael W. M. Kühn, Juerg Schwaller, Clemens Cammann, Ulrike Seifert, Frédéric Ebstein, Elke Krüger, Andreas Hochhaus, Michael Heuser, Alessandro Ori, Matthias Mann, Scott A. Armstrong, Florian H. Heidel
Publikováno v:
Molecular Cancer, Vol 22, Iss 1, Pp 1-21 (2023)
Abstract Pharmacologic targeting of chromatin-associated protein complexes has shown significant responses in KMT2A-rearranged (KMT2A-r) acute myeloid leukemia (AML) but resistance frequently develops to single agents. This points to a need for thera
Externí odkaz:
https://doaj.org/article/32a44bd3490c43d78d23fc64b13aaac5
Autor:
Florian Perner, Homa Rahnamoun, Daniela V. Wenge, Yijun Xiong, Athina Apazidis, Disha Anand, Charlie Hatton, Yanhe Wen, Shengqing Gu, X Shirley Liu, Wenbin Xiao, Sheng F. Cai, Ross L. Levine, Gerard M. Mcgeehan, Scott A. Armstrong
Publikováno v:
HemaSphere, Vol 7, p e6233123 (2023)
Externí odkaz:
https://doaj.org/article/576f5a4c6dfd45daabbe17b293ba2228
Autor:
Lu Yang, Anthony K. N. Chan, Kazuya Miyashita, Christopher D. Delaney, Xi Wang, Hongzhi Li, Sheela Pangeni Pokharel, Sandra Li, Mingli Li, Xiaobao Xu, Wei Lu, Qiao Liu, Nicole Mattson, Kevin Yining Chen, Jinhui Wang, Yate-Ching Yuan, David Horne, Steven T. Rosen, Yadira Soto-Feliciano, Zhaohui Feng, Takayuki Hoshii, Gang Xiao, Markus Müschen, Jianjun Chen, Scott A. Armstrong, Chun-Wei Chen
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Identifying functional domains and genetic regulatory mechanisms is essential for developing new therapies. Here the authors present sc-Tiling, single-cell high-density CRISPR tiling screening for functional domain characterization.
Externí odkaz:
https://doaj.org/article/ddb7b59f991343969e3fce23606cbf5c
Autor:
Hidetaka Niizuma, Adam C. Searleman, Shugaku Takeda, Scott A. Armstrong, Christopher Y. Park, Emily H. Cheng, James J. Hsieh
Publikováno v:
JCI Insight, Vol 6, Iss 15 (2021)
Taspase1, a highly conserved threonine protease encoded by TASP1, cleaves nuclear histone-modifying factors and basal transcription regulators to orchestrate diverse transcription programs. Hereditary loss-of-function mutation of TASP1 has recently b
Externí odkaz:
https://doaj.org/article/7956a9ca77924a61ba02c8b4da109902
Autor:
S. Haihua Chu, Jonathan R. Chabon, Chloe N. Matovina, Janna C. Minehart, Bo-Ruei Chen, Jian Zhang, Vipul Kumar, Yijun Xiong, Elsa Callen, Putzer J. Hung, Zhaohui Feng, Richard P. Koche, X. Shirley Liu, Jayanta Chaudhuri, Andre Nussenzweig, Barry P. Sleckman, Scott A. Armstrong
Publikováno v:
iScience, Vol 23, Iss 3, Pp - (2020)
Summary: Repair of DNA double-stranded breaks (DSBs) during lymphocyte development is essential for V(D)J recombination and forms the basis of immunoglobulin variable region diversity. Understanding of this process in lymphogenesis has historically b
Externí odkaz:
https://doaj.org/article/7b6e87225d7445a5aff36d4d395224c3
Autor:
Kavitha Ramaswamy, Lauren Forbes, Gerard Minuesa, Tatyana Gindin, Fiona Brown, Michael G. Kharas, Andrei V. Krivtsov, Scott A. Armstrong, Eric Still, Elisa de Stanchina, Birgit Knoechel, Richard Koche, Alex Kentsis
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
MYB activity is a key factor for the maintenance of acute myeloid leukemias but it is also a difficult target. Here, the authors develop a peptidomimetic (MYBMIM) that prevents the interaction of the trans-activation domain of MYB with the KIX domain
Externí odkaz:
https://doaj.org/article/a470abd9ea4643cfb47136bbe875cfb7
Autor:
Florian Perner, Scott A. Armstrong
Publikováno v:
Cells, Vol 9, Iss 12, p 2721 (2020)
The aberrant function of chromatin regulatory networks (epigenetics) is a hallmark of cancer promoting oncogenic gene expression. A growing body of evidence suggests that the disruption of specific chromatin-associated protein complexes has therapeut
Externí odkaz:
https://doaj.org/article/5266701f1c244f35ab8db8e5c8b60e3d
Autor:
Etienne Danis, Taylor Yamauchi, Kristen Echanique, Xi Zhang, Jessica N. Haladyna, Simone S. Riedel, Nan Zhu, Huafeng Xie, Stuart H. Orkin, Scott A. Armstrong, Kathrin M. Bernt, Tobias Neff
Publikováno v:
Cell Reports, Vol 14, Iss 8, Pp 1953-1965 (2016)
Early T cell precursor acute lymphoblastic leukemia (ETP-ALL) is an aggressive subtype of ALL distinguished by stem-cell-associated and myeloid transcriptional programs. Inactivating alterations of Polycomb repressive complex 2 components are frequen
Externí odkaz:
https://doaj.org/article/1a481861ef994065bf3a95b20c803c62
Autor:
Dongjun Lee, Stephen M. Sykes, Demetrios Kalaitzidis, Andrew A. Lane, Youmna Kfoury, Marc H.G.P. Raaijmakers, Ying-Hua Wang, Scott A. Armstrong, David T. Scadden
Publikováno v:
Stem Cell Reports, Vol 3, Iss 5, Pp 832-840 (2014)
Central to cellular proliferative, survival, and metabolic responses is the serine/threonine kinase mTOR, which is activated in many human cancers. mTOR is present in distinct complexes that are either modulated by AKT (mTORC1) or are upstream and re
Externí odkaz:
https://doaj.org/article/22c060d236194a41b424b906c33bff0d
Autor:
Michael W.M. Kühn, Michael J. Hadler, Scott R. Daigle, Richard P. Koche, Andrei V. Krivtsov, Edward J. Olhava, Michael A. Caligiuri, Gang Huang, James E. Bradner, Roy M. Pollock, Scott A. Armstrong
Publikováno v:
Haematologica, Vol 100, Iss 5 (2015)
Externí odkaz:
https://doaj.org/article/dcb0db050f0649f7b220df543be1f0a0