Zobrazeno 1 - 10
of 282
pro vyhledávání: '"Scott A Small"'
Autor:
Xinyang Feng, Jia Guo, Hannah C Sigmon, Richard P Sloan, Adam M Brickman, Frank A Provenzano, Scott A Small, Alzheimer’s Disease Neuroimaging Initiative
Publikováno v:
PLoS ONE, Vol 15, Iss 7, p e0234255 (2020)
'Normal aging' in the brain refers to age-related changes that occur independent of disease, in particular Alzheimer's disease. A major barrier to mapping normal brain aging has been the difficulty in excluding the earliest preclinical stages of Alzh
Externí odkaz:
https://doaj.org/article/0957878b619644e89357c6b79e3d6770
Autor:
Li Liu, Valerie Drouet, Jessica W Wu, Menno P Witter, Scott A Small, Catherine Clelland, Karen Duff
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e31302 (2012)
Tauopathy in the brain of patients with Alzheimer's disease starts in the entorhinal cortex (EC) and spreads anatomically in a defined pattern. To test whether pathology initiating in the EC spreads through the brain along synaptically connected circ
Externí odkaz:
https://doaj.org/article/c3290960259e4ec9a3089042ea462901
Autor:
Chen Liu, Nanyan Zhu, Haoran Sun, Junhao Zhang, Xinyang Feng, Sabrina Gjerswold-Selleck, Dipika Sikka, Xuemin Zhu, Xueqing Liu, Tal Nuriel, Hong-Jian Wei, Cheng-Chia Wu, J. Thomas Vaughan, Andrew F. Laine, Frank A. Provenzano, Scott A. Small, Jia Guo
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
While MRI contrast agents such as those based on Gadolinium are needed for high-resolution mapping of brain metabolism, these contrast agents require intravenous administration, and there are rising concerns over their safety and invasiveness. Furthe
Externí odkaz:
https://doaj.org/article/9e36da58adf7405cbffbe5a76a2c545a
Autor:
Richard P. Sloan, Melanie Wall, Lok-Kin Yeung, Tianshu Feng, Xinyang Feng, Frank Provenzano, Hagen Schroeter, Vincenzo Lauriola, Adam M. Brickman, Scott A. Small
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract With the world's population aging, age-related memory decline is an impending cognitive epidemic. Assessing the impact of diet on cognitive aging, we conducted a controlled, randomized, parallel-arm dietary intervention with 211 healthy adul
Externí odkaz:
https://doaj.org/article/136ab5a0d12347c7806bb87435516791
Molecular analysis reveals a high diversity of Anopheles species in Karama, West Sulawesi, Indonesia
Autor:
Jenna R. Davidson, Isra Wahid, Rusdiyah Sudirman, Scott T. Small, Allison L. Hendershot, Robert N. Baskin, Timothy A. Burton, Victoria Makuru, Honglin Xiao, Xiaoyu Yu, Emma V. Troth, Daniel Olivieri, Stephanny Lizarraga, Hajar Hasan, Andi Arfah, Muhammad Yusuf, Nirwana Nur, Din Syafruddin, Puji Asih, Neil F. Lobo
Publikováno v:
Parasites & Vectors, Vol 13, Iss 1, Pp 1-11 (2020)
Abstract Background Understanding local Anopheles species compositions and bionomic traits are vital for an effective malaria vector intervention strategy. Though eight malaria vectors, including species complexes, have been documented across the isl
Externí odkaz:
https://doaj.org/article/5fbcf9ab47554acab5abb393fab0f978
Autor:
Rakshathi Basavaraju, Jeanelle France, Hannah C. Sigmon, Ragy R. Girgis, Gary Brucato, Jeffrey A. Lieberman, Scott A. Small, Frank A. Provenzano
Publikováno v:
Schizophrenia Research. 255:246-255
Autor:
Allison Knupp, Swati Mishra, Refugio Martinez, Jacquelyn E. Braggin, Marcell Szabo, Chizuru Kinoshita, Dale W. Hailey, Scott A. Small, Suman Jayadev, Jessica E. Young
Publikováno v:
Cell Reports, Vol 31, Iss 9, Pp - (2020)
Summary: SORL1/SORLA is a sorting receptor involved in retromer-related endosomal traffic and an Alzheimer’s disease (AD) risk gene. Using CRISPR-Cas9, we deplete SORL1 in hiPSCs to ask if loss of SORL1 contributes to AD pathogenesis by endosome dy
Externí odkaz:
https://doaj.org/article/19746c1d19d847c3a60732df360c1e8c
Autor:
Martin Lukindu, Christina M. Bergey, Rachel M. Wiltshire, Scott T. Small, Brian P. Bourke, Jonathan K. Kayondo, Nora J. Besansky
Publikováno v:
Parasites & Vectors, Vol 11, Iss 1, Pp 1-12 (2018)
Abstract Background Understanding population genetic structure in the malaria vector Anopheles gambiae (s.s.) is crucial to inform genetic control and manage insecticide resistance. Unfortunately, species characteristics such as high nucleotide diver
Externí odkaz:
https://doaj.org/article/cbe6a048bed7424ead9d12cd3c368294
Autor:
André M. Miranda, Zofia M. Lasiecka, Yimeng Xu, Jessi Neufeld, Sanjid Shahriar, Sabrina Simoes, Robin B. Chan, Tiago Gil Oliveira, Scott A. Small, Gilbert Di Paolo
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Neurodegeneration is increasingly associated with endolysosomal and autophagy dysfunction. Here, Miranda and colleagues show that disruption of neuronal PI3P/Vps34 signaling leads to endolysosomal membrane damage and aberrant release of undigested ma
Externí odkaz:
https://doaj.org/article/86b0425ec6574642a7fb5c502f85d7c0
Autor:
Xinyang Feng, Marla J. Hamberger, Hannah C. Sigmon, Jia Guo, Scott A. Small, Frank A. Provenzano
Publikováno v:
NeuroImage: Clinical, Vol 19, Iss , Pp 911-917 (2018)
Steady-state cerebral blood volume (CBV) is tightly coupled to regional cerebral metabolism, and CBV imaging is a variant of MRI that has proven useful in mapping brain dysfunction. CBV derived from exogenous contrast-enhanced MRI can generate sub-mi
Externí odkaz:
https://doaj.org/article/c77953026bee4ef1a69b474857c5fef7