Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Scott A, Noggle"'
Autor:
Liuliu Yang, Yuling Han, Ting Zhou, Lauretta A. Lacko, Mohsan Saeed, Christina Tan, Ron Danziger, Jiajun Zhu, Zeping Zhao, Clare Cahir, Alice Maria Giani, Yang Li, Xue Dong, Dorota Moroziewicz, Daniel Paull, Zhengming Chen, Aaron Zhong, Scott A. Noggle, Charles M. Rice, Qibin Qi, Todd Evans, Shuibing Chen
Publikováno v:
iScience, Vol 26, Iss 7, Pp 107001- (2023)
Summary: Population-based genome-wide association studies (GWAS) normally require a large sample size, which can be labor intensive and costly. Recently, we reported a human induced pluripotent stem cell (hiPSC) array-based GWAS method, identifying N
Externí odkaz:
https://doaj.org/article/692df0b5246247cd9c258ce33dcea793
Autor:
Lauren Schiff, Bianca Migliori, Ye Chen, Deidre Carter, Caitlyn Bonilla, Jenna Hall, Minjie Fan, Edmund Tam, Sara Ahadi, Brodie Fischbacher, Anton Geraschenko, Christopher J. Hunter, Subhashini Venugopalan, Sean DesMarteau, Arunachalam Narayanaswamy, Selwyn Jacob, Zan Armstrong, Peter Ferrarotto, Brian Williams, Geoff Buckley-Herd, Jon Hazard, Jordan Goldberg, Marc Coram, Reid Otto, Edward A. Baltz, Laura Andres-Martin, Orion Pritchard, Alyssa Duren-Lubanski, Ameya Daigavane, Kathryn Reggio, NYSCF Global Stem Cell Array® Team, Phillip C. Nelson, Michael Frumkin, Susan L. Solomon, Lauren Bauer, Raeka S. Aiyar, Elizabeth Schwarzbach, Scott A. Noggle, Frederick J. Monsma, Daniel Paull, Marc Berndl, Samuel J. Yang, Bjarki Johannesson
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
By coupling robotic cell culture systems with artificial intelligence–powered image analysis, Schiff et al. identify previously unseen characteristics of Parkinson’s disease in patient skin cells that distinguish them from healthy controls.
Externí odkaz:
https://doaj.org/article/9d8265097577462f83aa83bf77ad2240
Autor:
Zaniar Ghazizadeh, Jiajun Zhu, Faranak Fattahi, Alice Tang, Xiaolu Sun, Sadaf Amin, Su-Yi Tsai, Mona Khalaj, Ting Zhou, Ryan M. Samuel, Tuo Zhang, Francis A. Ortega, Miriam Gordillo, Dorota Moroziewicz, Daniel Paull, Scott A. Noggle, Jenny Zhaoying Xiang, Lorenz Studer, David J. Christini, Geoffrey S. Pitt, Todd Evans, Shuibing Chen
Publikováno v:
iScience, Vol 25, Iss 4, Pp 104153- (2022)
Summary: The sinoatrial node (SAN) is the primary pacemaker of the heart. The human SAN is poorly understood due to limited primary tissue access and limitations in robust in vitro derivation methods. We developed a dual SHOX2:GFP; MYH6:mCherry knock
Externí odkaz:
https://doaj.org/article/fef061437c7f48f58546ebc077cf20d3
Autor:
Maria Carmen Inda, Suhasini Joshi, Tai Wang, Alexander Bolaender, Srinivasa Gandu, John Koren III, Alicia Yue Che, Tony Taldone, Pengrong Yan, Weilin Sun, Mohammad Uddin, Palak Panchal, Matthew Riolo, Smit Shah, Afsar Barlas, Ke Xu, Lon Yin L. Chan, Alexandra Gruzinova, Sarah Kishinevsky, Lorenz Studer, Valentina Fossati, Scott A. Noggle, Julie R. White, Elisa de Stanchina, Sonia Sequeira, Kyle H. Anthoney, John W. Steele, Katia Manova-Todorova, Sujata Patil, Mark P. Dunphy, NagaVaraKishore Pillarsetty, Ana C. Pereira, Hediye Erdjument-Bromage, Thomas A. Neubert, Anna Rodina, Stephen D. Ginsberg, Natalia De Marco Garcia, Wenjie Luo, Gabriela Chiosis
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
The biology of Alzheimer’s disease (AD) remains unknown. We propose AD is a protein connectivity-based dysfunction disorder whereby a switch of the chaperome into epichaperomes rewires proteome-wide connectivity, leading to brain circuitry malfunct
Externí odkaz:
https://doaj.org/article/c776838301d2406eb50617b6e0cb86a1
Autor:
Kavya Reddy, Corey L. Cusack, Israel C. Nnah, Khoosheh Khayati, Chaitali Saqcena, Tuong B. Huynh, Scott A. Noggle, Andrea Ballabio, Radek Dobrowolski
Publikováno v:
Cell Reports, Vol 14, Iss 9, Pp 2166-2179 (2016)
Attenuated auto-lysosomal system has been associated with Alzheimer disease (AD), yet all underlying molecular mechanisms leading to this impairment are unknown. We show that the amino acid sensing of mechanistic target of rapamycin complex 1 (mTORC1
Externí odkaz:
https://doaj.org/article/1bf113a6d88040d1b143230f1332c503
Autor:
Chris M. Woodard, Brian A. Campos, Sheng-Han Kuo, Melissa J. Nirenberg, Michael W. Nestor, Matthew Zimmer, Eugene V. Mosharov, David Sulzer, Hongyan Zhou, Daniel Paull, Lorraine Clark, Eric E. Schadt, Sergio Pablo Sardi, Lee Rubin, Kevin Eggan, Mathew Brock, Scott Lipnick, Mahendra Rao, Stephen Chang, Aiqun Li, Scott A. Noggle
Publikováno v:
Cell Reports, Vol 9, Iss 4, Pp 1173-1182 (2014)
Parkinson’s disease (PD) has been attributed to a combination of genetic and nongenetic factors. We studied a set of monozygotic twins harboring the heterozygous glucocerebrosidase mutation (GBA N370S) but clinically discordant for PD. We applied i
Externí odkaz:
https://doaj.org/article/f58586c88b724b98b595eefa2674fd1d
Autor:
Carina, Seah, Michael S, Breen, Tom, Rusielewicz, Heather N, Bader, Changxin, Xu, Christopher J, Hunter, Barry, McCarthy, P J Michael, Deans, Mitali, Chattopadhyay, Jordan, Goldberg, Frank, Desarnaud, Iouri, Makotkine, Janine D, Flory, Linda M, Bierer, Migle, Staniskyte, Scott A, Noggle, Laura M, Huckins, Daniel, Paull, Kristen J, Brennand, Matthew, Zimmer
Publikováno v:
Nature neuroscience. 25(11)
Post-traumatic stress disorder (PTSD) can develop following severe trauma, but the extent to which genetic and environmental risk factors contribute to individual clinical outcomes is unknown. Here, we compared transcriptional responses to hydrocorti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5668c11ec938f167d3a9faa104b432d3
https://pubmed.ncbi.nlm.nih.gov/36266471
https://pubmed.ncbi.nlm.nih.gov/36266471
Autor:
Nicholas J. Fiore, Yosif M. Ganat, Kapil Devkota, Rebecca Batorsky, Ming Lei, Kyongbum Lee, Lenore J. Cowen, Gist Croft, Scott A. Noggle, Thomas J. F. Nieland, David L. Kaplan
Publikováno v:
Cell Mol Life Sci
Three-dimensional (3D) in vitro culture systems using human induced pluripotent stem cells (hiPSCs) are useful tools to model neurodegenerative disease biology in physiologically relevant microenvironments. Though many successful biomaterials-based 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b13a7d9c0b6684855c76ace62223f354
https://europepmc.org/articles/PMC8908880/
https://europepmc.org/articles/PMC8908880/
Autor:
Davide Marotta, Jana Stoudemire, Twyman Clements, Jeanne F. Loring, Paula Grisanti, Scott A. Noggle, Valentina Fossati
Publikováno v:
Spaceflight and the Central Nervous System ISBN: 9783031184390
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f505c56414ece9d71f5d673b538e21d2
https://doi.org/10.1007/978-3-031-18440-6_9
https://doi.org/10.1007/978-3-031-18440-6_9
Autor:
Zaniar, Ghazizadeh, Jiajun, Zhu, Faranak, Fattahi, Alice, Tang, Xiaolu, Sun, Sadaf, Amin, Su-Yi, Tsai, Mona, Khalaj, Ting, Zhou, Ryan M, Samuel, Tuo, Zhang, Francis A, Ortega, Miriam, Gordillo, Dorota, Moroziewicz, Daniel, Paull, Scott A, Noggle, Jenny Zhaoying, Xiang, Lorenz, Studer, David J, Christini, Geoffrey S, Pitt, Todd, Evans, Shuibing, Chen
Publikováno v:
iScience. 25(4)
The sinoatrial node (SAN) is the primary pacemaker of the heart. The human SAN is poorly understood due to limited primary tissue access and limitations in robust
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d519a640ec8271ca23bd68d2f96d3e1b
https://pubmed.ncbi.nlm.nih.gov/35434558
https://pubmed.ncbi.nlm.nih.gov/35434558