Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Scott A, Maidment"'
Autor:
Tetsuya Yasuhiro, Masato Higashino, Keisuke Hazama, Scott A. Maidment, Miki Nakanishi, Nobuto Nakanishi, Mark S. Chambers, Gary Clark, Seishi Katsumata, Soichi Kawaharada, Shuji Kaneko, Arwel Lewis
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 366:58-65
GABAA receptors containing α5 subunits (GABAAα5) are highly expressed in the hippocampus and negatively involved in memory processing, as shown by the fact that GABAAα5–deficient mice show higher hippocampus-dependent performance than wild-type
Autor:
C. Rouse, Gary Clark, K.L. Hirst, H. Habashita, A.P. Owens, M. Higashino, S. Kawahadara, A. Imagawa, Arwel Lewis, Scott A. Maidment, A.M. Macleod, A. Rae, A. Beresford, Grant Wishart, M. Nakanishi, M.S. Chambers, T. Saito, D.C. Hartley
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 30:127536
The identification and SAR development of a series of negative allosteric modulators of the GABAA α5 receptor is described. This novel series of compounds was optimised to provide analogues with high GABAA α5 binding affinity, high α5 negative all
Autor:
Soichi, Kawaharada, Miki, Nakanishi, Nobuto, Nakanishi, Keisuke, Hazama, Masato, Higashino, Tetsuya, Yasuhiro, Arwel, Lewis, Gary S, Clark, Mark S, Chambers, Scott A, Maidment, Seishi, Katsumata, Shuji, Kaneko
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 366(1)
GABA
Autor:
Miki Nakanishi, Kim Louise Hirst, Tetsuya Yasuhiro, Nobuto Nakanishi, Scott A. Maidment, Masato Higashino, Seishi Katsumata, Gary Clark, Mark Stuart Chambers, Soichi Kawaharada, Arwel Lewis, Keisuke Hazama, Grant Wishart
Publikováno v:
Alzheimer's & Dementia. 12
Autor:
Miki Nakanishi, Nobuto Nakanishi, Scott A. Maidment, Keisuke Hazama, Arwel Lewis, Masato Higashino, Tetsuya Yasuhiro, Mark Stuart Chambers, Alastair Rae, Gary Clark, Soichi Kawaharada, Seishi Katsumata, Kim Louise Hirst, Grant Wishart
Publikováno v:
Alzheimer's & Dementia. 11
Autor:
Scott A. Maidment, Matthew Gardener, Simon Dowler, Anthony Lawrence, Tristana von Will, Andrew Southan, Gary Clark, Omar Aziz
Publikováno v:
Biophysical Journal. 96(3)
The KCNQ (Kv7) family of voltage gated ion channels conduct a number of hyperpolarising currents in various tissue types, including the heteromultimeric KCNQ2/3 M-current found in sensory neurones. Cell lines constructed using constitutive expression
Autor:
Rebecca Prime, Matthew Gardener, Andrew Southan, Scott A. Maidment, Tristana von Will, Steven England, Gary Clark, Edward Stevens, Elizabeth Payne
Publikováno v:
Biophysical Journal. (3):672a
The advent of high-throughput electrophysiology utilizing Population Patch Clamp™ (PPC) technology has allowed the screening of large compound libraries against ion channels representing novel targets in a variety of disease states. Here we report