Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Scott A, Mackler"'
Autor:
Taufiqul Huque, Beverly J Cowart, Luba Dankulich-Nagrudny, Edmund A Pribitkin, Douglas L Bayley, Andrew I Spielman, Roy S Feldman, Scott A Mackler, Joseph G Brand
Publikováno v:
PLoS ONE, Vol 4, Iss 10, p e7347 (2009)
BACKGROUND:The perception of sour taste in humans is incompletely understood at the receptor cell level. We report here on two patients with an acquired sour ageusia. Each patient was unresponsive to sour stimuli, but both showed normal responses to
Externí odkaz:
https://doaj.org/article/e8fda366c07147eaaac4634d19c495b3
Autor:
Peter W. Kalivas, Laxminarayana Korutla, Trevor G. Jackson, Scott A. Mackler, Michael D. Scofield
Publikováno v:
Neuroscience. 227:44-54
Protein degradation is a critical component of cellular maintenance. The intracellular translocation and targeting of the Ubiquitin Proteasome System (UPS) differentially coordinates a protein’s half-life and thereby its function. Nucleus Accumbens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b367a93ba93d9a2b4a44be26f948ff5c
https://doi.org/10.1016/j.neuroscience.2012.09.043
https://doi.org/10.1016/j.neuroscience.2012.09.043
Autor:
Alana C. Conti, Scott A. Mackler, Julie A. Blendy, Peter W. Kalivas, Ryan Degnan, Ying Homan, Alejandra M. Pacchioni
Publikováno v:
Behavioural Brain Research. 187:48-55
NAC1 is a novel member of the POZ/BTB (Pox virus and Zinc finger/Bric-a-brac Tramtrack Broad complex) but varies from other proteins of this class in that it lacks the characteristic DNA-binding motif, suggesting a novel role. We have employed consti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d23b28ce55fd6a2620c6c1ed46a627d
https://doi.org/10.1016/j.bbr.2007.08.036
https://doi.org/10.1016/j.bbr.2007.08.036
Publikováno v:
Journal of Neurochemistry. 101:611-618
In this report, CoREST was identified as a protein that interacts with NAC1. NAC1 is a cocaine-regulated Pox virus and Zinc finger/Bric-a-brac Tramtrack Broad complex (POZ/BTB) repressor protein, which mediates interactions among several other transc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::560c25cff84bce1e60e9466a6b770e90
https://doi.org/10.1111/j.1471-4159.2006.04387.x
https://doi.org/10.1111/j.1471-4159.2006.04387.x
Autor:
Scott A. Mackler, Hao-Wei Shen, Peter W. Kalivas, Matthias Klugman, Laxman Korutla, Nicholas Champtiaux
Publikováno v:
European Journal of Neuroscience. 22:397-403
The expression of the transcriptional regulator NAC1 is increased in the nucleus accumbens of rats withdrawn from cocaine self-administration, and in vivo studies indicate that the up-regulation is a compensatory mechanism opposing the acute effects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::034a5fc1245e91db197640fc48f168a8
https://doi.org/10.1111/j.1460-9568.2005.04208.x
https://doi.org/10.1111/j.1460-9568.2005.04208.x
The POZ/BTB protein NAC1 interacts with two different histone deacetylases in neuronal-like cultures
Publikováno v:
Journal of Neurochemistry. 94:786-793
NAC1 is a cocaine-regulated POZ/BTB (Pox virus and Zinc finger/Bric-a-brac Tramtrack Broad complex) protein. NAC1 is increased by cocaine selectively in the nucleus accumbens, a CNS region important for drug addiction. NAC1's role in the cell, howeve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f1265ff288d8c6e41d44f161d4b6ddb0
https://doi.org/10.1111/j.1471-4159.2005.03206.x
https://doi.org/10.1111/j.1471-4159.2005.03206.x
Publikováno v:
Neuroscience. 121:355-361
NAC1 cDNA was identified as a novel transcript induced in the nucleus accumbens from rats chronically treated with cocaine. NAC1 is a member of the Bric-a-brac Tramtrac Broad complex/Pox virus and Zinc finger family of transcription factors and has b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba4693d01507cd0bfc7f718065220b1f
https://doi.org/10.1016/s0306-4522(03)00376-2
https://doi.org/10.1016/s0306-4522(03)00376-2
Autor:
Laxminarayana Korutla, Michael F. Stromberg, J.H Neustadter, D.M Lewis, P. J. Wang, Scott A. Mackler
Publikováno v:
Neuroscience. 110:421-429
BTB/POZ proteins can influence the cell cycle and contribute to oncogenesis. Many family members are present in the mammalian CNS. Previous work demonstrated elevated NAC1 mRNA levels in the rat nucleus accumbens in response to cocaine. NAC1 acts lik
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ca7293e7073e82ce09f8d338fe96e63
https://doi.org/10.1016/s0306-4522(01)00518-8
https://doi.org/10.1016/s0306-4522(01)00518-8
Publikováno v:
Alcohol. 23:109-116
Both acamprosate and naltrexone have demonstrated clinical utility in reducing relapse to alcohol use in recovering alcoholics. The present experiments examined the effects of acamprosate and naltrexone, either alone or in combination, on basal ethan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26a2fb33c271712dd878fd9e4d33c570
https://doi.org/10.1016/s0741-8329(00)00137-3
https://doi.org/10.1016/s0741-8329(00)00137-3
Publikováno v:
Teratology. 61:305-313
Neural tube defects (NTDs), although prevalent and easily diagnosed, are etiologically heterogeneous, rendering mechanistic interpretation problematic. To date, there is evidence that mammalian neural tube closure (NTC) initiates and fuses intermitte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ae6cbbc5a03cf18547b6524f745fa0af
https://doi.org/10.1002/(sici)1096-9926(200004)61:4<305::aid-tera10>3.0.co
https://doi.org/10.1002/(sici)1096-9926(200004)61:4<305::aid-tera10>3.0.co