Zobrazeno 1 - 10
of 256
pro vyhledávání: '"Scott A, Hammond"'
Autor:
Colin Y. C. Lee, Bethany C. Kennedy, Nathan Richoz, Isaac Dean, Zewen K. Tuong, Fabrina Gaspal, Zhi Li, Claire Willis, Tetsuo Hasegawa, Sarah K. Whiteside, David A. Posner, Gianluca Carlesso, Scott A. Hammond, Simon J. Dovedi, Rahul Roychoudhuri, David R. Withers, Menna R. Clatworthy
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Tumour dendritic cells (DCs) internalise antigen and upregulate CCR7, which directs their migration to tumour-draining lymph nodes (dLN). CCR7 expression is coupled to an activation programme enriched in regulatory molecule expression, inclu
Externí odkaz:
https://doaj.org/article/a9dead2996844a5bb3e43c7e6aa7f935
Rapid functional impairment of natural killer cells following tumor entry limits anti-tumor immunity
Autor:
Isaac Dean, Colin Y. C. Lee, Zewen K. Tuong, Zhi Li, Christopher A. Tibbitt, Claire Willis, Fabrina Gaspal, Bethany C. Kennedy, Veronika Matei-Rascu, Rémi Fiancette, Caroline Nordenvall, Ulrik Lindforss, Syed Murtuza Baker, Christian Stockmann, Veronika Sexl, Scott A. Hammond, Simon J. Dovedi, Jenny Mjösberg, Matthew R. Hepworth, Gianluca Carlesso, Menna R. Clatworthy, David R. Withers
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Immune cell dysfunction within the tumor microenvironment (TME) undermines the control of cancer progression. Established tumors contain phenotypically distinct, tumor-specific natural killer (NK) cells; however, the temporal dynamics, mecha
Externí odkaz:
https://doaj.org/article/27d36aa7031e441daba36d10fc106a98
Autor:
Larry R. Dalton, Juerg Leuthold, Bruce H. Robinson, Christian Haffner, Delwin L. Elder, Lewis E. Johnson, Scott R. Hammond, Wolfgang Heni, Claudia Hosessbacher, Benedikt Baeuerle, Eva De Leo, Ueli Koch, Patrick Habegger, Yuriy Fedoryshyn, David Moor, Ping Ma
Publikováno v:
APL Materials, Vol 11, Iss 5, Pp 050901-050901-21 (2023)
The growth of integrated photonics has driven the need for efficient, high-bandwidth electrical-to-optical (EO) signal conversion over a broad range of frequencies (MHz–THz), together with efficient, high bandwidth photodetection. Efficient signal
Externí odkaz:
https://doaj.org/article/a45e4070eef64acbad03f55e6d1a3ac1
Autor:
Vijay Swahari, Ayumi Nakamura, Emilie Hollville, Hume Stroud, Jeremy M. Simon, Travis S. Ptacek, Matthew V. Beck, Cornelius Flowers, Jiami Guo, Charlotte Plestant, Jie Liang, C. Lisa Kurtz, Matt Kanke, Scott M. Hammond, You-Wen He, E.S. Anton, Praveen Sethupathy, Sheryl S. Moy, Michael E. Greenberg, Mohanish Deshmukh
Publikováno v:
Cell Reports, Vol 35, Iss 1, Pp 108946- (2021)
Summary: Although embryonic brain development and neurodegeneration have received considerable attention, the events that govern postnatal brain maturation are less understood. Here, we identify the miR-29 family to be strikingly induced during the l
Externí odkaz:
https://doaj.org/article/6b13303fc7034e6a9dac5a4c09887e7b
Autor:
Claire Germain, Priyanka Devi-Marulkar, Samantha Knockaert, Jérôme Biton, Hélène Kaplon, Laïla Letaïef, Jérémy Goc, Agathe Seguin-Givelet, Dominique Gossot, Nicolas Girard, Pierre Validire, Marine Lefèvre, Diane Damotte, Marco Alifano, François M. Lemoine, Keith E. Steele, Jean-Luc Teillaud, Scott A. Hammond, Marie-Caroline Dieu-Nosjean
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The presence of tertiary lymphoid structures (TLS) in the tumor microenvironment is associated with better clinical outcome in many cancers. In non-small cell lung cancer (NSCLC), we have previously showed that a high density of B cells within TLS (T
Externí odkaz:
https://doaj.org/article/757b1a291fa64d989f66f304930a5ace
Autor:
Darren J. Schofield, Jennifer Percival-Alwyn, Mateusz Rytelewski, John Hood, Raymond Rothstein, Leslie Wetzel, Kelly McGlinchey, Grace Adjei, Amanda Watkins, LeeAnn Machiesky, Weimin Chen, John Andrews, Maria Groves, Michelle Morrow, Ross A. Stewart, Andrew Leinster, Robert W. Wilkinson, Scott A. Hammond, Nadia Luheshi, Claire Dobson, Michael Oberst
Publikováno v:
mAbs, Vol 13, Iss 1 (2021)
Preclinical studies of PD-L1 and CTLA-4 blockade have relied heavily on mouse syngeneic tumor models with intact immune systems, which facilitate dissection of immunosuppressive mechanisms in the tumor microenvironment. Commercially developed monoclo
Externí odkaz:
https://doaj.org/article/5b7084f79f5a4c06ad3eff39bdaa115c
Publikováno v:
The Journal of Immunology. 210:496-503
The thymus is a hormone-sensitive organ, which involutes with age in response to production of sex steroids. Thymic involution leads to a decrease in the generation of recent thymic emigrants (RTEs), resulting in a reduced response to immune challeng
Autor:
Jonathan W. Goldman, Sarina A. Piha-Paul, Brendan Curti, Katrina S. Pedersen, Todd M. Bauer, Stefanie L. Groenland, Richard D. Carvajal, Vaishali Chhaya, Gray Kirby, Kelly McGlinchey, Scott A. Hammond, Katie Streicher, Danielle M. Townsley, Young Kwang Chae, Jens Voortman, Aurelien Marabelle, John Powderly
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research, 28(17), 3709-3719. American Association for Cancer Research Inc.
Goldman, J W, Piha-Paul, S A, Curti, B, Pedersen, K S, Bauer, T M, Groenland, S L, Carvajal, R D, Chhaya, V, Kirby, G, McGlinchey, K, Hammond, S A, Streicher, K, Townsley, D M, Chae, Y K, Voortman, J, Marabelle, A & Powderly, J 2022, ' Safety and Tolerability of MEDI0562, an OX40 Agonist mAb, in Combination with Durvalumab or Tremelimumab in Adult Patients with Advanced Solid Tumors ', Clinical cancer research : an official journal of the American Association for Cancer Research, vol. 28, no. 17, pp. 3709-3719 . https://doi.org/10.1158/1078-0432.CCR-21-3016
Goldman, J W, Piha-Paul, S A, Curti, B, Pedersen, K S, Bauer, T M, Groenland, S L, Carvajal, R D, Chhaya, V, Kirby, G, McGlinchey, K, Hammond, S A, Streicher, K, Townsley, D M, Chae, Y K, Voortman, J, Marabelle, A & Powderly, J 2022, ' Safety and Tolerability of MEDI0562, an OX40 Agonist mAb, in Combination with Durvalumab or Tremelimumab in Adult Patients with Advanced Solid Tumors ', Clinical cancer research : an official journal of the American Association for Cancer Research, vol. 28, no. 17, pp. 3709-3719 . https://doi.org/10.1158/1078-0432.CCR-21-3016
Purpose: Combination therapies targeting immunologic checkpoints have shown promise in treating multiple tumor types. We report safety and tolerability of MEDI0562, a humanized IgG1K OX40 mAb, in combination with durvalumab (anti-PD-L1), or tremelimu
Autor:
Scott A. Hammond, Andrew Weinberg, Nicholas P. Morris, Louis Picker, Michael K. Axthelm, Andrew Sylwester, Haesun Park, Andrew J. Pierce, Lolke de Haan, Nicholas Buss, Steven Eck, Hui Feng, Melissa Damschroder, Qun Du, Shino Hanabuchi, James Hair, Kelly McGlinchey, Kathy Mulgrew, Stacy Kentner, Chad Morris, Catherine Augé, Michael D. Oberst
Expression of cell surface Fc gamma receptors on human cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::123f7d8216dfd0b1f3ce6f1f64cd89ab
https://doi.org/10.1158/1535-7163.22505539.v1
https://doi.org/10.1158/1535-7163.22505539.v1
Autor:
Samir N. Khleif, Seema Gupta, Mikayel Mkrtichyan, John E. Janik, Scott A. Hammond, Harlan Robins, Catherine Sanders, Erik Yusko, Rachel M. Gittelman, Pankaj Gaur, Sudha Ananth, Peng Zeng, Vivek Verma, Shamim Ahmad, Rajeev K. Shrimali
Effects of the combination therapy of anti-OX40 and anti-PD-1 Abs with tumor vaccine on spleen and tumor T-cell infiltration and clonality.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44c63ff14df19403c3f2a7fca5a301e1
https://doi.org/10.1158/2326-6066.22539581
https://doi.org/10.1158/2326-6066.22539581