Zobrazeno 1 - 10
of 239
pro vyhledávání: '"Scott A. Lesley"'
Autor:
Sarah M Rue, Paul W Anderson, Jessica M Miller, Salvatore G Fanale, Jim Y Chang, Scott M Glaser, Scott A Lesley
Publikováno v:
BioTechniques, Vol 65, Iss 4, Pp 224-226 (2018)
High-throughput protein expression platforms are increasingly used to produce proteins for many applications: to support studies in structure/function, regulation and proteomics, as well as for direct use as potential biotherapeutic agents for medica
Externí odkaz:
https://doaj.org/article/1fb7d5852f3c42f8952aa8152c44b311
Autor:
Tamara Reyes-Robles, Aleksandra K. Olow, Tyler J. Bechtel, Scott A. Lesley, Olugbeminiyi O. Fadeyi, Rob C. Oslund
Publikováno v:
ACS chemical biology. 17(8)
Receptor tyrosine kinases are involved in essential signaling roles that impact cell growth, differentiation, and proliferation. The overexpression or mutation of these proteins can lead to aberrant signaling that has been directly linked to a number
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cc6925e254a5d939ca67757b63afb24
https://pubmed.ncbi.nlm.nih.gov/35939534
https://pubmed.ncbi.nlm.nih.gov/35939534
Autor:
Qingping Xu, Dominique Mengin-Lecreulx, Xueqian W. Liu, Delphine Patin, Carol L. Farr, Joanna C. Grant, Hsiu-Ju Chiu, Lukasz Jaroszewski, Mark W. Knuth, Adam Godzik, Scott A. Lesley, Marc-André Elsliger, Ashley M. Deacon, Ian A. Wilson
Publikováno v:
mBio, Vol 6, Iss 5 (2015)
ABSTRACT Bacterial SH3 (SH3b) domains are commonly fused with papain-like Nlp/P60 cell wall hydrolase domains. To understand how the modular architecture of SH3b and NlpC/P60 affects the activity of the catalytic domain, three putative NlpC/P60 cell
Externí odkaz:
https://doaj.org/article/66e5fd174c9b48308e36f26975b3b4c4
Autor:
Marc C Deller, Hope A Johnson, Mitchell D Miller, Glen Spraggon, Marc-André Elsliger, Ian A Wilson, Scott A Lesley
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0122512 (2015)
The TM1088 locus of T. maritima codes for two proteins designated TM1088A and TM1088B, which combine to form the cytosolic portion of a putative Trk K+ transporter. We report the crystal structure of this assembly to a resolution of 3.45 Å. The high
Externí odkaz:
https://doaj.org/article/786a0a1d07d640b7a732a35ec3596383
Autor:
Qingping Xu, Marc C Deller, Tine K Nielsen, Joanna C Grant, Scott A Lesley, Marc-André Elsliger, Ashley M Deacon, Ian A Wilson
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e107309 (2014)
Kanadaptin is a nuclear protein of unknown function that is widely expressed in mammalian tissues. The crystal structure of the forkhead-associated (FHA) domain of human kanadaptin was determined to 1.6 Å resolution. The structure reveals an asymmet
Externí odkaz:
https://doaj.org/article/927ce7732ffc4266a9e4e2067c26f1d5
Autor:
Christine A. Andrews, Scott A. Lesley
Publikováno v:
BioTechniques, Vol 24, Iss 6, Pp 972-980 (1998)
Conventional approaches to oligonucleotide-directed mutagenesis rely upon the application of a selection strategy to maximize mutagenesis efficiencies. We have developed a mutagenesis procedure that incorporates a novel antibiotic resistance for sele
Externí odkaz:
https://doaj.org/article/ee39adc55a0f4d2cac4d3fd0de3265ae
Autor:
Catharine L. Eastman, Gregory B. Chisholm, Julie Vance, Kai Zinn, Dirk Siepe, Heath E. Klock, K. Christopher Garcia, Scott Martin Glaser, Scott A. Lesley, Sarah Cox, Woj M. Wojtowicz, Jost Vielmetter, Ricardo A. Fernandes, Paul Anderson, Melisa L. Bragstad, Annie W. Lam, Jessica J. Miller, Sarah Rue
Publikováno v:
Cell
Summary Cell-surface protein-protein interactions (PPIs) mediate cell-cell communication, recognition, and responses. We executed an interactome screen of 564 human cell-surface and secreted proteins, most of which are immunoglobulin superfamily (IgS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdb88b5e0a3459806af75a948cee0f7a
https://pubmed.ncbi.nlm.nih.gov/32822567
https://pubmed.ncbi.nlm.nih.gov/32822567
Autor:
Qingping Xu, Gilles P van Wezel, Hsiu-Ju Chiu, Lukasz Jaroszewski, Heath E Klock, Mark W Knuth, Mitchell D Miller, Scott A Lesley, Adam Godzik, Marc-André Elsliger, Ashley M Deacon, Ian A Wilson
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e41359 (2012)
Actinomycetes are important bacterial sources of antibiotics and other secondary metabolites. Many antibiotic gene clusters are controlled by pathway-specific activators that act in response to growth conditions. Here we present the crystal structure
Externí odkaz:
https://doaj.org/article/22bb6da506f943bd8bc2e65b7fefc3c6
Autor:
Qingping Xu, Gilles P. van Wezel, Hsiu-Ju Chiu, Lukasz Jaroszewski, Heath E. Klock, Mark W. Knuth, Mitchell D. Miller, Scott A. Lesley, Adam Godzik, Marc-André Elsliger, Ashley M. Deacon, Ian A. Wilson
Publikováno v:
PLoS ONE, Vol 7, Iss 8 (2012)
Externí odkaz:
https://doaj.org/article/57d43aff9e024711b4ba64682fb8eb2c
Autor:
Abhinav Kumar, Sabine Möcklinghoff, Fumiaki Yumoto, Lukasz Jaroszewski, Carol L Farr, Anna Grzechnik, Phuong Nguyen, Christian X Weichenberger, Hsiu-Ju Chiu, Heath E Klock, Marc-André Elsliger, Ashley M Deacon, Adam Godzik, Scott A Lesley, Bruce R Conklin, Robert J Fletterick, Ian A Wilson
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e43761 (2012)
The human nuclear factor related to kappa-B-binding protein (NFRKB) is a 1299-residue protein that is a component of the metazoan INO80 complex involved in chromatin remodeling, transcription regulation, DNA replication and DNA repair. Although full
Externí odkaz:
https://doaj.org/article/ea0eeba6acc149beb88802036b6c31a7