Restrictive versus Liberal Rate of Extracorporeal Volume Removal Evaluation in Acute Kidney Injury (RELIEVE-AKI): a pilot clinical trial protocol

Autor: Paul M Palevsky, David T Huang, Kianoush Kashani, Chung-Chou H Chang, Andrea Kattah, Brad Butcher, Raghavan Murugan, Maham Raza, Nasrin Nikravangolsefid, Ali Al-Khafaji, Philip Lamberty, Firas Abdulmajeed, Scott Gunn, Michele Elder, Denise Scholl, William Sabol, Tina Vita

Publikováno v: BMJ Open, Vol 13, Iss 7 (2023)

Introduction Observational studies have linked slower and faster net ultrafiltration (UFNET) rates during kidney replacement therapy (KRT) with mortality in critically ill patients with acute kidney injury (AKI) and fluid overload. To inform the desi

Externí odkaz: https://doaj.org/article/6fea52a8bda54bfe87a923cbf98e6277

The Ectopic Expression of Meiosis Regulatory Genes in Cutaneous T-Cell Lymphomas (CTCL)

Autor: Jennifer Gantchev, Amelia Martínez Villarreal, Pingxing Xie, Philippe Lefrançois, Scott Gunn, Elena Netchiporouk, Denis Sasseville, Ivan V. Litvinov

Publikováno v: Frontiers in Oncology, Vol 9 (2019)

Cancer testis (CT) antigens, under normal circumstances are uniquely expressed in testicular germ cells. Recent research has shown that meiosis-specific CT (meiCT) antigens are ectopically expressed in cutaneous T-cell lymphoma (CTCL) and may contrib

Externí odkaz: https://doaj.org/article/92debf7a3d77480ebf0a5bc34db01059

In silico analyses of the tumor microenvironment highlight tumoral inflammation, a Th2 cytokine shift and a mesenchymal stem cell-like phenotype in advanced in basal cell carcinomas

Autor: Ivan V. Litvinov, Scott Gunn, Philippe Lefrançois, Jennifer Gantchev, Denis Sasseville, Amelia Martínez Villarreal, Pingxing Xie

Publikováno v: J Cell Commun Signal

Basal Cell Carcinoma (BCC) represents the most common form of all cancers. BCC is characteristically surrounded by a fibromyxoid stroma. Previous studies have suggested a shift towards a Th2 response, an increase in T regulatory lymphocytes and the p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b88b964cd3f9eba90fd497ceced5c6d
https://doi.org/10.1007/s12079-020-00563-6

Illness-related suffering and need for palliative care in Rohingya refugees and caregivers in Bangladesh: A cross-sectional study

Autor: Richard A Powell, Brett Sutton, Megan Doherty, Liam Power, Farzana Khan, Liz Grant, Scott Gunn, Rachel Coghlan, Mila Petrova

Publikováno v: PLoS Medicine
PLoS Medicine, Vol 17, Iss 3, p e1003011 (2020)
Doherty, M, Power, L, Petrova, M, Gunn, S, Powell, R, Coghlan, R, Grant, L, Sutton, B & Khan, F 2020, ' Illness-related suffering and need for palliative care in Rohingya refugees and caregivers in Bangladesh : A cross-sectional study ', PLoS Medicine, vol. 17, no. 3, pp. e1003011 . https://doi.org/10.1371/journal.pmed.1003011

Background Despite recognition that palliative care is an essential component of any humanitarian response, serious illness-related suffering continues to be pervasive in these settings. There is very limited evidence about the need for palliative ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54fd625af4b894b67ec23ab4ac026af4
https://www.repository.cam.ac.uk/handle/1810/303006

The transcriptional landscape analysis of basal cell carcinomas reveals novel signalling pathways and actionable targets

Autor: Denis Sasseville, Philippe Lefrançois, Ivan V. Litvinov, Scott Gunn, Pingxing Xie

Publikováno v: Life Science Alliance

Basal cell carcinoma (BCC) is the most common skin cancer and human malignancy. By analyzing BCC RNA sequencing data according to clinically important features, we identified novel differentially regulated genes and new targetable pathways. Several b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09ed0b05fd642b161481663f85e4de13
https://doi.org/10.26508/lsa.202000651