Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Scott, Gardner"'
Autor:
Scott Gardner, Yibo Jin, Paul K. Fyfe, Tomas B. Voisin, Junel Sotolongo Bellón, Elizabeth Pohler, Jacob Piehler, Ignacio Moraga, Doryen Bubeck
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract IL-11 and IL-6 activate signalling via assembly of the cell surface receptor gp130; however, it is unclear how signals are transmitted across the membrane to instruct cellular responses. Here we solve the cryoEM structure of the IL-11 recept
Externí odkaz:
https://doaj.org/article/bbc396d2171b448a8f4b408bf1d66f66
Autor:
Emma C. Couves, Scott Gardner, Tomas B. Voisin, Jasmine K. Bickel, Phillip J. Stansfeld, Edward W. Tate, Doryen Bubeck
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
CD59 protects human cells from damage by the MAC immune pore. The authors show how CD59 inhibits MAC, by deflecting pore-forming β-hairpins of complement proteins. As well as how the membrane environment influences the role of CD59 in complement reg
Externí odkaz:
https://doaj.org/article/1d86c42b34e04084a69e7434c448c724
Autor:
Scott Gardner, Cody Carpenter, Jacob Tuia, Aaron Skousen, Dustin Badger, Sandra Thomas, Bradley R. Adams, Dale R. Tree, Andrew R. Fry
Publikováno v:
Results in Engineering, Vol 18, Iss , Pp 101192- (2023)
A pressurized oxy-coal (POC) reactor has been designed, built and tested to investigate key technologies related to oxy-coal combustion including a dry coal feed system, an oxy-coal burner, and a slagging ash management system. The coal feed system u
Externí odkaz:
https://doaj.org/article/28222e297be74b318d16fb76e1811439
Autor:
Antonio Di Maio, Molly McGrath, Muyuan Niu, Yan Liu, Scott Gardner, Douglas Sammon, Doryen Bubeck, Rhodri Marc Morgan, Erhard Hohenester
Publikováno v:
Wellcome Open Research, Vol 8 (2023)
Background: Hyaluronic acid (HA) is a major polysaccharide component of the extracellular matrix. HA has essential functions in tissue architecture and the regulation of cell behaviour. HA turnover needs to be finely balanced. Increased HA degradatio
Externí odkaz:
https://doaj.org/article/9db2c6b794e94a3baa901d2f6d86a797
Publikováno v:
Frontiers in Medicine, Vol 8 (2021)
Objective: The purpose of this study was to evaluate the impact of capacity-building short-term mission service trips to Sierra Leone on local health education and perspectives.Methods: This was a prospective, mixed-methods study. During three missio
Externí odkaz:
https://doaj.org/article/fe60ab50ac824cf8a220bbcb92355569
Autor:
Anaïs Menny, Marina Serna, Courtney M. Boyd, Scott Gardner, Agnel Praveen Joseph, B. Paul Morgan, Maya Topf, Nicholas J. Brooks, Doryen Bubeck
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
The complement membrane attack complex (MAC) is a lytic immune pore that kills pathogens. Here the authors use cryoEM to provide a structural and biophysical mechanism for how β-pore forming proteins breach the lipid bilayer, providing pathways to e
Externí odkaz:
https://doaj.org/article/4bd0eaed6b53416380fc69476cf0e63b
Autor:
Scott Gardner, Michele C. Darrow, Natalya Lukoyanova, Konstantinos Thalassinos, Helen R. Saibil
The bacterial chaperonin GroEL-GroES promotes protein folding through ATP-regulated cycles of substrate protein binding, encapsulation, and release. Here, we have used cryoEM to determine structures of GroEL, GroEL-ADP.BeF3, and GroEL-ADP.AlF3-GroES
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::24317f24acf8dba81f1ccde9da36ad3f
https://doi.org/10.1101/2023.05.29.542693
https://doi.org/10.1101/2023.05.29.542693
Publikováno v:
Journal of Great Lakes Research. 48:455-467
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8197c911dce626d68533f3f1a0f85dc9
https://doi.org/10.1016/j.jglr.2022.01.021
https://doi.org/10.1016/j.jglr.2022.01.021
Publikováno v:
Journal of Trauma and Acute Care Surgery. 91:981-987
BACKGROUND Little is known about patient characteristics predicting postdischarge pleural space complications (PDPSCs) after thoracic trauma. We sought to analyze the patient population who required unplanned hospital readmission for PDPSC. METHODS R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f978e49bda759d48959c316b0385d0f7
https://doi.org/10.1097/ta.0000000000003408
https://doi.org/10.1097/ta.0000000000003408
Autor:
Zachary M. Bauman, Andrew R. Doben, Kiara Leasia, Brian Kim, Thomas W. White, Emily Cantrell, Matthew C. Hernandez, Sebastian D. Schubl, Matthew Barns, Evert A. Eriksson, Erika Tay Lasso, Sarah Majercik, D. Benjamin Christie, Angela Sauaia, Scott Gardner, Sean Dieffenbaugher, Fredric M. Pieracci
Publikováno v:
Journal of Trauma and Acute Care Surgery. 90:1014-1021
BACKGROUND Prospective studies of surgical stabilization of rib fractures (SSRF) have excluded elderly patients, and no study has exclusively addressed the ≥80-year-old subgroup. We hypothesized that SSRF is associated with decreased mortality in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d9e0a86d08ff841bcc3e248e4a3c28f
https://doi.org/10.1097/ta.0000000000003140
https://doi.org/10.1097/ta.0000000000003140