hsa-MiR-19a-3p and hsa-MiR-19b-3p Are Associated with Spinal Cord Injury-Induced Neuropathic Pain: Findings from a Genome-Wide MicroRNA Expression Profiling Screen

Autor: Scott Falci, Karen L. Troy, Nguyen Nguyen, Clas Linnman, Leslie R. Morse, Liang Ye, Ricardo A. Battaglino, Mayank Shrivastava, Julie K. Olson

Publikováno v: Neurotrauma Reports

Neuropathic pain in spinal cord injury (SCI) is associated with inflammation in both the peripheral and central nervous system (CNS), which may contribute to the initiation and maintenance of persistent pain. An understanding of factors contributing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47ee9bf9f38b533fd25d7a2969731fed
https://doi.org/10.1089/neur.2021.0011

Transplantation of Human Neural Precursor Cells Reverses Syrinx Growth in a Rat Model of Post-Traumatic Syringomyelia

Autor: Åke Seiger, Anna Falk, Scott Falci, Emilia Rotstein, Eirikur Benedikz, Ning Xu, Xiaofei Li, Elisabet Åkesson, Erik Sundström, Tingting Xu, Raymond V. Mirasol, Lena Holmberg, Per Henrik Vincent

Publikováno v: Xu, N, Xu, T, Mirasol, R, Holmberg, L, Vincent, P H, Li, X, Falk, A, Benedikz, E, Rotstein, E, Seiger, Å, Åkesson, E, Falci, S & Sundström, E 2021, ' Transplantation of Human Neural Precursor Cells Reverses Syrinx Growth in a Rat Model of Post-Traumatic Syringomyelia ', Neurotherapeutics, vol. 18, no. 2, pp. 1257-1272 . https://doi.org/10.1007/s13311-020-00987-3
Neurotherapeutics

Posttraumatic syringomyelia (PTS) is a serious condition of progressive expansion of spinal cord cysts, affecting patients with spinal cord injury years after injury. To evaluate neural cell therapy to prevent cyst expansion and potentially replace l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::677eac4dcfc2f3191a431bf95f61e26a
https://findresearcher.sdu.dk:8443/ws/files/199463983/Xu2021_Article_TransplantationOfHumanNeuralPr.pdf

69742 miR-338-5p as a Biomarker of Neuropathic Pain After Spinal Cord Injury

Autor: Ricardo A. Battaglino, Jesse L. Kowalski, Susan Charlie, Leslie R. Morse, Nguyen Nguyen, Scott Falci

Publikováno v: Journal of Clinical and Translational Science. 5:89-90

IMPACT: Identification of microRNA (miRNA) associated with neuropathic pain after spinal cord injury (SCI) will elucidate underlying epigenetic mechanisms contributing to its development and identify targets for intervention to optimize treatment str

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e56589cc5b8341a964e5320beeb8b0c2
https://doi.org/10.1017/cts.2021.632

Spinal cord injury below-level neuropathic pain relief with dorsal root entry zone microcoagulation performed caudal to level of complete spinal cord transection

Autor: Scott Falci, Charlotte Indeck, Dave Barnkow

Publikováno v: Journal of neurosurgery. Spine. 28(6)

OBJECTIVESurgically created lesions of the spinal cord dorsal root entry zone (DREZ) to relieve central pain after spinal cord injury (SCI) have historically been performed at and cephalad to, but not below, the level of SCI. This study was initiated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47bf65a8c4ffbad4af4135e9c816f65c
https://pubmed.ncbi.nlm.nih.gov/29498583

Morphine amplifies mechanical allodynia via TLR4 in a rat model of spinal cord injury

Autor: Linda R. Watkins, Monica T. Ayala, Mark R. Hutchinson, Bryce Skarda, Kendra Springer, Steven F. Maier, Julie Wieseler, Peter M. Grace, Amanda Ellis, Kenner C. Rice, Jacob Favret, Scott Falci

Central neuropathic pain (CNP) is a pervasive, debilitating problem that impacts thousands of people living with central nervous system disorders, including spinal cord injury (SCI). Current therapies for treating this type of pain are ineffective an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::964b043304fdeea83d055c4cfcccfe59
https://europepmc.org/articles/PMC5067205/