Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Scott, Eagon"'
Autor:
Chloe D. Wong, Kimiya Ganjooi, Maetja Verbarendse, Jessica M. Travis, Mark H. S. Troftgruben, Hannah R. Mora, Isabella Oldenburg, Robert Lammert, Horacio Lazaro, Scott Eagon
Publikováno v:
Synthetic Communications. 53:32-39
A silver carbonate-based method to synthesize benzoxazoles from imines has been developed. The reaction is extremely mild, tolerates several heterocycles and functional groups, and provides highly functionalized benzoxazoles in modest to good yields.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89af733cb3a39f41d22a98320ace50d7
https://doi.org/10.1080/00397911.2022.2148223
https://doi.org/10.1080/00397911.2022.2148223
Autor:
Hunter Johnson, Cameron Gleason, Trevan Klug, Connor Schmid, Ryan Schioldager, Celine DiBernardo, Scott Eagon
Publikováno v:
Organic Preparations and Procedures International. 54:435-439
Improved Synthesis of 5-Ethylsulfonyl-2-methoxyaniline
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd3ce8a5532a1fb0519824a4a457e2b6
https://doi.org/10.1080/00304948.2022.2072154
https://doi.org/10.1080/00304948.2022.2072154
Autor:
Marc O. Anderson, Martina Sigal, Ashley Cheung, Jared T. Hammill, Anna S Kashtanova, Korina Eribez, Lauren Loop, Horacio Lazaro, Irene García-Barbazán, Cory A. Chaplan, Kenya Yniguez, Benigno Crespo, Alisje Churchyard, Mofolusho O. Falade, Grant Koch, Briana Belanger, Celine DiBernardo, Jake Baum, Julia E Tryhorn, Amy L. Rice, Katie Kim, Joshua J. Kimball, R. Kiplin Guy, Steven Wilkinson, Benoît Laleu, Nimisha Mittal, Rei Takahashi, Elizabeth A. Winzeler, Francisco-Javier Gamo, Scott Eagon, Kevin J Ahn
Publikováno v:
Journal of Medicinal Chemistry. 63:11902-11919
Malaria remains one of the most deadly infectious diseases, causing hundreds of thousands of deaths each year, primarily in young children and pregnant mothers. Here, we report the discovery and derivatization of a series of pyrazolo[3,4-b]pyridines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b79d343cc463a5cc1561c5e53694b2dc
https://doi.org/10.1021/acs.jmedchem.0c01152
https://doi.org/10.1021/acs.jmedchem.0c01152
Autor:
Brandon Nguyen, Julia Elizabeth Glidden, Scott Eagon, Kasey Fitzsimmons, Jared T. Hammill, Kara Thompson, Jarvis Law, Mofolusho O. Falade, Steven Wilkinson, Amy L. Rice, Celine DiBernardo, Natalie Sienko, R. Kiplin Guy, Aashrita Manjunath, Joshua J. Kimball
Publikováno v:
Bioorganicmedicinal chemistry letters. 47
Malaria remains one of the deadliest diseases on the planet, infecting an estimated 229 million individuals in 2019 with more than 400,000 associated deaths, primarily in young children and pregnant women. 1 Malaria is caused by Plasmodium parasite i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b242d421005f920cc4d5a97d076ff9f
https://pubmed.ncbi.nlm.nih.gov/34157390
https://pubmed.ncbi.nlm.nih.gov/34157390
Publikováno v:
Bioorganic & Medicinal Chemistry Letters
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ac6230810f835414918a1e5b7897b0f
https://pubmed.ncbi.nlm.nih.gov/33775840
https://pubmed.ncbi.nlm.nih.gov/33775840
Autor:
Jordan Bach, Jared T. Hammill, Mofolusho O. Falade, R. Kiplin Guy, Scott Eagon, Nikalet Everson, Amy L. Rice
Publikováno v:
Bioorganicmedicinal chemistry letters. 35
A virtual screen was performed to identify anti-malarial compounds targeting Plasmodium falciparum heat shock 90 protein by applying a series of drug-like and commercial availability filters to compounds in the ZINC database, resulting in a virtual l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a9ad5db5011f78f7ce1ef23d4cd16c5
https://pubmed.ncbi.nlm.nih.gov/33513390
https://pubmed.ncbi.nlm.nih.gov/33513390
Autor:
Scott, Eagon, Jared T, Hammill, Martina, Sigal, Kevin J, Ahn, Julia E, Tryhorn, Grant, Koch, Briana, Belanger, Cory A, Chaplan, Lauren, Loop, Anna S, Kashtanova, Kenya, Yniguez, Horacio, Lazaro, Steven P, Wilkinson, Amy L, Rice, Mofolusho O, Falade, Rei, Takahashi, Katie, Kim, Ashley, Cheung, Celine, DiBernardo, Joshua J, Kimball, Elizabeth A, Winzeler, Korina, Eribez, Nimisha, Mittal, Francisco-Javier, Gamo, Benigno, Crespo, Alisje, Churchyard, Irene, García-Barbazán, Jake, Baum, Marc O, Anderson, Benoît, Laleu, R Kiplin, Guy
Publikováno v:
Journal of medicinal chemistry. 63(20)
Malaria remains one of the most deadly infectious diseases, causing hundreds of thousands of deaths each year, primarily in young children and pregnant mothers. Here, we report the discovery and derivatization of a series of pyrazolo[3,4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7e9b7615d65f5856c40bca0cc86bf7b8
https://pubmed.ncbi.nlm.nih.gov/32945666
https://pubmed.ncbi.nlm.nih.gov/32945666
Autor:
Amy L. Rice, Celine DiBernardo, Jordan Bach, Tyler A Sisley, Scott Eagon, R. Kiplin Guy, Mofolusho O. Falade, Sierra D. Durham, Nikalet Everson, Joshua J. Kimball, Dylan R. Pillai, Michael J. Walls, Jared T. Hammill, Horacio Lazaro
Publikováno v:
Bioorganicmedicinal chemistry letters. 30(21)
A series of tetrahydro-β-carboline derivatives of a lead compound known to target the heat shock 90 protein of Plasmodium falciparum were synthesized and assayed for both potency against the parasite and toxicity against a human cell line. Using a r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae6e24616f77f17e1ad702d12cbcb3db
https://pubmed.ncbi.nlm.nih.gov/32822760
https://pubmed.ncbi.nlm.nih.gov/32822760
Autor:
Aashrita Manjunath, Hunter Johnson, Trevan Klug, Nathan Soderberg, Ryan Schioldager, Connor Schmid, Cameron Gleason, Scott Eagon, Horacio Lazaro, Eli O'Brien, Adam Cronin, Duminda Liyanage, Joshua J. Kimball
Publikováno v:
Tetrahedron Letters. 88:153555
A microwave mediated synthesis of 2-aminooxazoles at 150 °C was developed, providing products with a variety of functional groups. The reaction takes 5 minutes and provides product with a simple precipitation at moderate to good yields without the n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f7cd651fbf98004aa3e4777d9f56fe04
https://doi.org/10.1016/j.tetlet.2021.153555
https://doi.org/10.1016/j.tetlet.2021.153555