Zobrazeno 1 - 10
of 363
pro vyhledávání: '"Scot R Kimball"'
Autor:
Jennifer L Steiner, Anne M Pruznak, Gina Deiter, Maithili Navaratnarajah, Lydia Kutzler, Scot R Kimball, Charles H Lang
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e99582 (2014)
Sepsis decreases skeletal muscle protein synthesis in part by impairing mTOR activity and the subsequent phosphorylation of 4E-BP1 and S6K1 thereby controlling translation initiation; however, the relative importance of changes in these two downstrea
Externí odkaz:
https://doaj.org/article/cc23a4fbb4b94a558fbeb6766d0c17fe
Publikováno v:
Physiological Reports, Vol 12, Iss 13, Pp n/a-n/a (2024)
Abstract Cancer cachexia is a multifactorial syndrome associated with advanced cancer that contributes to mortality. Cachexia is characterized by loss of body weight and muscle atrophy. Increased skeletal muscle mitochondrial reactive oxygen species
Externí odkaz:
https://doaj.org/article/5c17bce384414ba9af9234037581913d
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e44711 (2012)
Synaptophysin, is an abundant presynaptic protein involved in synaptic vesicle recycling and neurotransmitter release. Previous work shows that its content is significantly reduced in the rat retina by streptozotocin (STZ)-diabetes. This study tested
Externí odkaz:
https://doaj.org/article/47db713fdffb41299dca02e5ec3460c7
Autor:
Heather D VanGuilder, Georgina V Bixler, Lydia Kutzler, Robert M Brucklacher, Sarah K Bronson, Scot R Kimball, Willard M Freeman
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e16271 (2011)
BACKGROUND: As a leading cause of adult blindness, diabetic retinopathy is a prevalent and profound complication of diabetes. We have previously reported duration-dependent changes in retinal vascular permeability, apoptosis, and mRNA expression with
Externí odkaz:
https://doaj.org/article/21068942c8e34a8f8a9a343ee2866307
Publikováno v:
Physiological Reports, Vol 12, Iss 3, Pp n/a-n/a (2024)
Abstract The protein kinase Mechanistic Target of Rapamycin (mTOR) in Complex 1 (mTORC1) is regulated in part by the Ras‐related GTP‐binding proteins (Rag GTPases). Rag GTPases form a heterodimeric complex consisting of either RagA or RagB associ
Externí odkaz:
https://doaj.org/article/6f9d836abb6a4934862041b4bf86bbec
Autor:
Jaclyn E. Welles, Holly Lacko, Yuka Imamura Kawasawa, Michael D. Dennis, Leonard S. Jefferson, Scot R. Kimball
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Consumption of a diet rich in saturated fatty acids and carbohydrates contributes to the accumulation of fat in the liver and development of non-alcoholic steatohepatitis (NASH). Herein we investigated the hypothesis that short-term consumption of a
Externí odkaz:
https://doaj.org/article/2fadb24ab0af425385ee86e53ffe166a
Autor:
Yeon Soo Kim, Priscilla W. Tang, Jaclyn E. Welles, Weihua Pan, Zaineb Javed, Amal Taher Elhaw, Karthikeyan Mythreye, Scot R. Kimball, Nadine Hempel
Publikováno v:
Redox Biology, Vol 53, Iss , Pp 102329- (2022)
During metastasis cancer cells must adapt to survive loss of anchorage and evade anoikis. An important pro-survival adaptation is the ability of metastatic tumor cells to increase their antioxidant capacity and restore cellular redox balance. Althoug
Externí odkaz:
https://doaj.org/article/c571266f755244c089d54da4b196f47b
Autor:
James Westley Heinle, Kara DiJoseph, Angelo Sabag, Sechang Oh, Scot R. Kimball, Shelley Keating, Jonathan G. Stine
Publikováno v:
Nutrients, Vol 15, Iss 11, p 2452 (2023)
Exercise remains a key component of nonalcoholic fatty liver disease (NAFLD) treatment. The mechanisms that underpin improvements in NAFLD remain the focus of much exploration in our attempt to better understand how exercise benefits patients with NA
Externí odkaz:
https://doaj.org/article/d6351fabe5d84bcda655f2a32cb0cfff
Autor:
Jonathan G. Stine, Jaclyn E. Welles, Shelley Keating, Zeba Hussaini, Christopher Soriano, J. Wes Heinle, Nathaniel Geyer, Vernon M. Chinchilli, Rohit Loomba, Scot R. Kimball
Publikováno v:
Nutrients, Vol 15, Iss 6, p 1481 (2023)
Background and Aims: Exercise remains a key component of nonalcoholic fatty liver disease (NAFLD) treatment. However, mechanisms underpinning the improvements in NAFLD seen with exercise are unclear. Exercise improved liver fat and serum biomarkers o
Externí odkaz:
https://doaj.org/article/39f74380cecf478e88ae1171c7a38eb0
Autor:
Paul A. Roberson, Gregory N. Kincheloe, Jaclyn E. Welles, Dandan Xu, Mahalia Sam-Clarke, Paul S. MacLean, Charles H. Lang, Leonard S. Jefferson, Scot R. Kimball
Publikováno v:
The Journal of Nutrition. 153:988-998