Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Scot Marsters"'
Autor:
Fátima Cairrão, Cristiana C. Santos, Adrien Le Thomas, Scot Marsters, Avi Ashkenazi, Pedro M. Domingos
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
In Drosophila, ER-targeted mRNAs are degraded by Ire1-dependent pathway. Here the authors report that the fly mRNA binding protein Pumilio is phosphorylated by Ire1 and binds to Xbp1 mRNA, protecting it from the non-canonical endoribonuclease activit
Externí odkaz:
https://doaj.org/article/4136424ab196470b833fcd5fa037db28
Autor:
Adrien Le Thomas, Elena Ferri, Scot Marsters, Jonathan M. Harnoss, David A. Lawrence, Iratxe Zuazo-Gaztelu, Zora Modrusan, Sara Chan, Margaret Solon, Cécile Chalouni, Weihan Li, Hartmut Koeppen, Joachim Rudolph, Weiru Wang, Thomas D. Wu, Peter Walter, Avi Ashkenazi
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
IRE1 helps mitigate endoplasmic-reticulum stress by cleaving specific mRNAs at a conserved sequence endomotif via regulated IRE1-dependent decay (RIDD). Here the authors discover a more promiscuous IRE1 activity dubbed RIDD lacking endomotif (RIDDLE)
Externí odkaz:
https://doaj.org/article/bef46ea29dad4d2bbd29966c9a96665b
Autor:
Pradeep M. Nair, Hai Ngu, Eric Torres, Scot Marsters, David A. Lawrence, Jean-Philippe Stephan, Laszlo Komuves, Avi Ashkenazi
Publikováno v:
BioTechniques, Vol 59, Iss 4, Pp 231-240 (2015)
We developed a strategy for identifying modulators of juxtacrine signaling, triggered by a cell-surface ligand displayed on synthetic lipid bilayers, via cognate receptors on apposed cells. Using readouts for receptor lateral transport and intracellu
Externí odkaz:
https://doaj.org/article/4f9530a5214145d583908e8e47334ef9
Autor:
Tom T. Chen, Ellen Filvaroff, Jing Peng, Scot Marsters, Adrian Jubb, Hartmut Koeppen, Mark Merchant, Avi Ashkenazi
Publikováno v:
EBioMedicine, Vol 2, Iss 5, Pp 406-420 (2015)
Hepatocyte growth factor (HGF) and vascular endothelial growth factor (VEGF) drive cancer through their respective receptors, MET and VEGF receptor 2 (VEGFR2). VEGFR2 inhibits MET by promoting MET dephosphorylation. However, whether MET conversely re
Externí odkaz:
https://doaj.org/article/9c7b6da9d2c34e51ba91b6081a3bcd8a
Autor:
Brian M. Castellano, Danming Tang, Scot Marsters, Cynthia Lam, Peter Liu, Christopher M. Rose, Wendy Sandoval, Avi Ashkenazi, Brad Snedecor, Shahram Misaghi
Publikováno v:
Biotechnology Progress.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33f2fca3e5301f2ef295874b5f887790
https://doi.org/10.1002/btpr.3354
https://doi.org/10.1002/btpr.3354
Autor:
null Brian M. Castellano, null Danming Tang, null Scot Marsters, null Cynthia Lam, null Peter Liu, null Christopher M. Rose, null Wendy Sandoval, null Avi Ashkenazi, null Brad Snedecor, null Shahram Misaghi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16f31f912e144cb5ab118ee18fb00b7d
https://doi.org/10.1002/btpr.3354/v2/response1
https://doi.org/10.1002/btpr.3354/v2/response1
Autor:
Paul J. Carter, Avi Ashkenazi, Mark Merchant, Yan Wu, Richard M. Neve, Genee Lee, Jarrod Tremayne, Jing Peng, Janet Tien, Scot Marsters, Stevan Djakovic, Yiyuan Yin
Supplementary Materials and Methods, Figures S1-5 and Tables S1-8. Supplementary Materials and Methods: More detailed description of Materials and Methods for experiments. Figure S1: Structural analysis of the FGFR3-IIIb and R3Mab complex. Figure S2:
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86ba9ca89ad5be616e44cc73cc5f518c
https://doi.org/10.1158/1535-7163.22502133
https://doi.org/10.1158/1535-7163.22502133
Antigen-derived peptides engage the ER stress sensor IRE1α to curb dendritic cell cross-presentation
Autor:
Ofer Guttman, Adrien Le Thomas, Scot Marsters, David A. Lawrence, Lauren Gutgesell, Iratxe Zuazo-Gaztelu, Jonathan M. Harnoss, Simone M. Haag, Aditya Murthy, Geraldine Strasser, Zora Modrusan, Thomas Wu, Ira Mellman, Avi Ashkenazi
Publikováno v:
The Journal of cell biology. 221(6)
Dendritic cells (DCs) promote adaptive immunity by cross-presenting antigen-based epitopes to CD8+ T cells. DCs process internalized protein antigens into peptides that enter the endoplasmic reticulum (ER), bind to major histocompatibility type I (MH
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe335d805b90423608ffa4001cc27a65
https://pubmed.ncbi.nlm.nih.gov/35544036
https://pubmed.ncbi.nlm.nih.gov/35544036
Autor:
Yanli Yang, Sherry H. Yeh, Shravan Madireddi, Wadim L. Matochko, Chen Gu, Patricia Pacheco Sanchez, Mark Ultsch, Gladys De Leon Boenig, Seth F. Harris, Brandon Leonard, Suzie J. Scales, Jing W. Zhu, Erin Christensen, Julie Q. Hang, Randall J. Brezski, Scot Marsters, Avi Ashkenazi, Siddharth Sukumaran, Henry Chiu, Rafael Cubas, Jeong M. Kim, Greg A. Lazar
Publikováno v:
mAbs
Agonism of members of the tumor necrosis factor receptor superfamily (TNFRSF) with monoclonal antibodies is of high therapeutic interest due to their role in immune regulation and cell proliferation. A major hurdle for pharmacologic activation of thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f5a54c9991525ce536360d89bf35e3c
http://europepmc.org/articles/PMC6748612
http://europepmc.org/articles/PMC6748612
Autor:
Clara, Montagut, Alba, Dalmases, Beatriz, Bellosillo, Marta, Crespo, Silvia, Pairet, Mar, Iglesias, Marta, Salido, Manuel, Gallen, Scot, Marsters, Siao Ping, Tsai, André, Minoche, Somasekar, Seshagiri, Seshagiri, Somasekar, Sergi, Serrano, Heinz, Himmelbauer, Joaquim, Bellmunt, Ana, Rovira, Jeff, Settleman, Francesc, Bosch, Joan, Albanell
Publikováno v:
Nature medicine. 18(2)
Antibodies against epidermal growth factor receptor (EGFR)--cetuximab and panitumumab--are widely used to treat colorectal cancer. Unfortunately, patients eventually develop resistance to these agents. We describe an acquired EGFR ectodomain mutation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22e5585f558ab360eff0be07f170850a
https://pubmed.ncbi.nlm.nih.gov/22310681
https://pubmed.ncbi.nlm.nih.gov/22310681