Simple nutrients bypass the requirement for HLH-30 in coupling lysosomal nutrient sensing to survival.

Autor: John T Murphy, Haiyan Liu, Xiucui Ma, Alex Shaver, Brian M Egan, Clara Oh, Alexander Boyko, Travis Mazer, Samuel Ang, Rohan Khopkar, Ali Javaheri, Sandeep Kumar, Xuntian Jiang, Daniel Ory, Kartik Mani, Scot J Matkovich, Kerry Kornfeld, Abhinav Diwan

Publikováno v: PLoS Biology, Vol 17, Iss 5, p e3000245 (2019)

Lysosomes are ubiquitous acidified organelles that degrade intracellular and extracellular material trafficked via multiple pathways. Lysosomes also sense cellular nutrient levels to regulate target of rapamycin (TOR) kinase, a signaling enzyme that

Externí odkaz: https://doaj.org/article/c52633b4ef644f0ebfbbc8300d13c9c3

Common miR-590 Variant rs6971711 Present Only in African Americans Reduces miR-590 Biogenesis.

Autor: Xiaoping Lin, Steven Steinberg, Suresh K Kandasamy, Junaid Afzal, Blaid Mbiyangandu, Susan E Liao, Yufan Guan, Celia P Corona-Villalobos, Scot J Matkovich, Neal Epstein, Dotti Tripodi, Zhaoxia Huo, Garry Cutting, Theodore P Abraham, Ryuya Fukunaga, M Roselle Abraham

Publikováno v: PLoS ONE, Vol 11, Iss 5, p e0156065 (2016)

MicroRNAs (miRNAs) are recognized as important regulators of cardiac development, hypertrophy and fibrosis. Recent studies have demonstrated that genetic variations which cause alterations in miRNA:target interactions can lead to disease. We hypothes

Externí odkaz: https://doaj.org/article/3083cf18fae34166813dbd5d0f4f83d3

A novel strategy to increase the proliferative potential of adult human β-cells while maintaining their differentiated phenotype.

Autor: Haytham Aly, Nidhi Rohatgi, Connie A Marshall, Tiffani C Grossenheider, Hiroyuki Miyoshi, Thaddeus S Stappenbeck, Scot J Matkovich, Michael L McDaniel

Publikováno v: PLoS ONE, Vol 8, Iss 6, p e66131 (2013)

Our previous studies demonstrated that Wnt/GSK-3/β-catenin and mTOR signaling are necessary to stimulate proliferative processes in adult human β-cells. Direct inhibition of GSK-3, that engages Wnt signaling downstream of the Wnt receptor, increase

Externí odkaz: https://doaj.org/article/5fd82f224eb0466dbcad8713a11f8da7

BET bromodomain inhibition attenuates cardiac phenotype in myocyte-specific lamin A/C–deficient mice

Autor: Ali J. Marian, Matthew J. Robertson, Leila Rouhi, Gaelle Auguste, Priyatansh Gurha, Cristian Coarfa, Grazyna Czernuszewicz, Scot J. Matkovich

Publikováno v: J Clin Invest

Mutation in the LMNA gene, encoding lamin A/C, causes a diverse group of diseases called laminopathies. Cardiac involvement is the major cause of death and manifests as dilated cardiomyopathy, heart failure, arrhythmias, and sudden death. There is no

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e242d9a9609211192f5dfb069950b61a
https://doi.org/10.1172/jci135922

Transcriptomic and Functional Analyses of Mitochondrial Dysfunction in Pressure Overload‐Induced Right Ventricular Failure

Autor: Ingrid S. Lan, Giovanni Fajardo, Ramesh V. Nair, Nefthi Sandeep, Daniel Bernstein, Scot J. Matkovich, Sushma Reddy, Mingming Zhao, Hyun Tae V. Hwang, Dong-Qing Hu

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 4 (2021)
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease

Background In complex congenital heart disease patients such as those with tetralogy of Fallot, the right ventricle (RV) is subject to pressure overload, leading to RV hypertrophy and eventually RV failure. The mechanisms that promote the transition

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f04b569bff81dbf5fe8a76c7beb90d3a
https://doi.org/10.1161/jaha.120.017835