Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Scot Campbell"'
Publikováno v:
Drug Metabolism and Disposition. 46:770-778
BI 187004, an 11β-hydroxysteroid dehydrogenase 1 inhibitor, was administered once daily for 14 days to eight patients with type 2 diabetes mellitus. N-methylation was identified as a major biotransformation pathway. In four patients treated with BI
Publikováno v:
Fruit Flies and the Sterile Insect Technique ISBN: 9781351072168
Fruit Flies and the Sterile Insect Technique
Fruit Flies and the Sterile Insect Technique
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b55d4099694a900961fa539b45b65ad7
https://doi.org/10.1201/9781351072168-13
https://doi.org/10.1201/9781351072168-13
Autor:
Ralf Kiesling, Stefan Aßfalg, Chris H. Senanayake, Nina C. Gonnella, Max Chevliakov, Matt Hrapchak, Bachir Latli, Carl A. Busacca, Scot Campbell
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 59:648-656
Dabigatran etexilate or pradaxa, a novel oral anticoagulant, is a reversible, competitive, direct thrombin inhibitor. It is used to prevent strokes in patients with atrial fibrillation and the formation of blood clots in the veins (deep venous thromb
Autor:
Chris H. Senanayake, Carl A. Busacca, Scot Campbell, Bachir Latli, Matt Hrapchak, Maxim Chevliakov, Guisheng Li
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 58:250-260
Deleobuvir, (2E)-3-(2-{1-[2-(5-bromopyrimidin-2-yl)-3-cyclopentyl-1-methyl-1H-indole-6-carboxamido]cyclobutyl}-1-methyl-1H-benzimidazol-6-yl)prop-2-enoic acid (1), is a non-nucleoside, potent, and selective inhibitor of hepatitis C virus NS5B polymer
Autor:
Jinhua J. Song, Bachir Latli, Matt Hrapchak, Xiao-Jun Wang, Chris H. Senanayake, Heewon Lee, Scot Campbell
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 57:687-694
Empagliflozin, (2S,3R,4R,5S,6R)-2-[4-chloro-3-[[4-[(3S)-oxolan-3-yl]oxyphenyl]methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triol was recently approved by the FDA for the treatment of chronic type 2 diabetes mellitus. Herein, we report the synthesis of
Autor:
Nitinchandra D. Patel, Xudong Wei, Nizar Haddad, Marisa C. Kozlowski, Jon C. Lorenz, Frank Himmelsbach, Nathan K. Yee, Zhulin Tan, Scot Campbell, Sergei Tcyrulnikov, Jun Wang, Chris H. Senanayake, Jean-Nicolas Desrosiers, Stefan Peters, Xingzhong Zeng, Maurice A. Marsini, Frederic G. Buono, Zhibin Li, Jolaine Savoie, Frank Roschangar, Bing-Shiou Yang, Keith R. Fandrick, Matthias Eckhardt, Heewon Lee, Wenjun Tang, Bo Qu, Jinhua J. Song, Shengli Ma, Osvaldo Gutierrez
Publikováno v:
Journal of the American Chemical Society. 138(47)
A concise asymmetric synthesis of an 11β-HSD-1 inhibitor has been achieved using inexpensive starting materials with excellent step-economy at low catalyst loadings. The catalytic enantioselective total synthesis of 1 was accomplished in 7 steps and
Autor:
Bachir, Latli, Ralf, Kiesling, Stefan, Aßfalg, Max, Chevliakov, Matt, Hrapchak, Scot, Campbell, Nina, Gonnella, Carl A, Busacca, Chris H, Senanayake
Publikováno v:
Journal of labelled compoundsradiopharmaceuticals. 59(14)
Dabigatran etexilate or pradaxa, a novel oral anticoagulant, is a reversible, competitive, direct thrombin inhibitor. It is used to prevent strokes in patients with atrial fibrillation and the formation of blood clots in the veins (deep venous thromb
Autor:
Carl A. Busacca, Scot Campbell, XuWu Feng, Nelu Grinberg, Varsolona Richard J, Paul-James Jones, Xudong Wei, Nizar Haddad, Oliver Niemeier, Chris H. Senanayake, Wendelin Samstag, Heewon Lee, Juergen Schroeder, Jana Vitous, Vittorio Farina, Nina C. Gonnella, Thilo Berkenbusch, Earl Spinelli, John A. Smoliga, Jon C. Lorenz, Suresh R. Kapadia, Zhibin Li, Max Sarvestani, Anjan Saha
Publikováno v:
Asian Journal of Organic Chemistry. 1:80-89
A concise synthetic route for large-scale manufacture of the hepatitis C virus (HCV) protease inhibitor BI 201335 has been developed. A convergent synthetic design was achieved by using three advanced intermediates: a densely functionalized thiazole-
Autor:
Jonathan T. Reeves, Heewon Lee, Zhulin Tan, Scot Campbell, Daniel R. Fandrick, Nathan K. Yee, Jinhua J. Song
Publikováno v:
Tetrahedron Letters. 51:4547-4551
Direct N-arylation of urea (5) with various arylboronic acids mediated by cupric acetate furnished BIRB796 and a range of N-substituted BIRB796 analogs in good to moderate yields in one step. Urea (5) was readily synthesized from commercially availab
Autor:
Daniel L. Norwood, Carl A. Busacca, Scot Campbell, Varsolona Richard J, Cerreta Michael Kenneth, John A. Smoliga, Nina C. Gonnella
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 51:1047-1053
A novel inhibitor of reverse transcriptase was studied by solid-state NMR. Three phases of the compound were examined which included the dihydrate and two anhydrous polymorphs (Form I and Form III). By correlating 1 H and 13 C solution NMR with the s