Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Scot C. Leary"'
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/f0cc38eb40cb433394fd530ed80abc44
Autor:
Kimberly A. Jett, Zakery N. Baker, Amzad Hossain, Aren Boulet, Paul A. Cobine, Sagnika Ghosh, Philip Ng, Orhan Yilmaz, Kris Barreto, John DeCoteau, Karen Mochoruk, George N. Ioannou, Christopher Savard, Sai Yuan, Osama H.M.H. Abdalla, Christopher Lowden, Byung-Eun Kim, Hai-Ying Mary Cheng, Brendan J. Battersby, Vishal M. Gohil, Scot C. Leary
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 1 (2023)
Signaling circuits crucial to systemic physiology are widespread, yet uncovering their molecular underpinnings remains a barrier to understanding the etiology of many metabolic disorders. Here, we identified a copper-linked signaling circuit activate
Externí odkaz:
https://doaj.org/article/018c1e9c28eb4a92a02a5abcb7afd106
Autor:
Maa O. Quartey, Jennifer N. K. Nyarko, Jason M. Maley, Jocelyn R. Barnes, Maria A. C. Bolanos, Ryan M. Heistad, Kaeli J. Knudsen, Paul R. Pennington, Josef Buttigieg, Carlos E. De Carvalho, Scot C. Leary, Matthew P. Parsons, Darrell D. Mousseau
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract The pool of β-Amyloid (Aβ) length variants detected in preclinical and clinical Alzheimer disease (AD) samples suggests a diversity of roles for Aβ peptides. We examined how a naturally occurring variant, e.g. Aβ(1–38), interacts with
Externí odkaz:
https://doaj.org/article/986c73bc802940a9ae4cdf2d043e1a43
Autor:
Christopher Lowden, Aren Boulet, Nicholas A. Boehler, Shavanie Seecharran, Julian Rios Garcia, Nicholas J. Lowe, Jiashu Liu, Jonathan L.K. Ong, Wanzhang Wang, Lingfeng Ma, Arthur H. Cheng, Adriano Senatore, D. Ashley Monks, Bao-hua Liu, Scot C. Leary, Hai-Ying Mary Cheng
Publikováno v:
Cell Reports, Vol 36, Iss 11, Pp 109704- (2021)
Summary: Histone variants are crucial regulators of chromatin structure and gene transcription, yet their functions within the brain remain largely unexplored. Here, we show that the H2A histone variant H2A.Z is essential for neuronal survival. Mice
Externí odkaz:
https://doaj.org/article/9ddb9e63dbef4337b6ecf22bdd986877
Autor:
Shivatheja Soma, Marcos N. Morgada, Mandar T. Naik, Aren Boulet, Anna A. Roesler, Nathaniel Dziuba, Alok Ghosh, Qinhong Yu, Paul A. Lindahl, James B. Ames, Scot C. Leary, Alejandro J. Vila, Vishal M. Gohil
Publikováno v:
Cell Reports, Vol 29, Iss 12, Pp 4114-4126.e5 (2019)
Summary: In eukaryotes, cellular respiration is driven by mitochondrial cytochrome c oxidase (CcO), an enzyme complex that requires copper cofactors for its catalytic activity. Insertion of copper into its catalytically active subunits, including COX
Externí odkaz:
https://doaj.org/article/6322aed5c16a4dc79ccf348a0f9dc969
Autor:
Christopher J. Hlynialuk, Binbing Ling, Zakery N. Baker, Paul A. Cobine, Lisa D. Yu, Aren Boulet, Timothy Wai, Amzad Hossain, Amr M. El Zawily, Pamela J. McFie, Scot J. Stone, Francisca Diaz, Carlos T. Moraes, Deepa Viswanathan, Michael J. Petris, Scot C. Leary
Publikováno v:
Cell Reports, Vol 10, Iss 6, Pp 933-943 (2015)
Human SCO1 fulfills essential roles in cytochrome c oxidase (COX) assembly and the regulation of copper (Cu) homeostasis, yet it remains unclear why pathogenic mutations in this gene cause such clinically heterogeneous forms of disease. Here, we esta
Externí odkaz:
https://doaj.org/article/0340b7e99d004b629b58872104cbc6a2
Autor:
Xinyu Zhu, Aren Boulet, Katherine M Buckley, Casey B Phillips, Micah G Gammon, Laura E Oldfather, Stanley A Moore, Scot C Leary, Paul A Cobine
Publikováno v:
eLife, Vol 10 (2021)
The mitochondrial carrier family protein SLC25A3 transports both copper and phosphate in mammals, yet in Saccharomyces cerevisiae the transport of these substrates is partitioned across two paralogs: PIC2 and MIR1. To understand the ancestral state o
Externí odkaz:
https://doaj.org/article/d7782b206ce2471e920d657626b83899
Autor:
Anjuman, Ara, Zhaojia, Wu, Aizhang, Xu, Khawaja Ashfaque, Ahmed, Scot C, Leary, Md Fahmid, Islam, Rajni, Chibbar, Yue, Wu, Jim, Xiang
Publikováno v:
International journal of molecular sciences. 23(17)
Two common γ-chain family cytokines IL-2 and IL-15 stimulate the same mammalian target of rapamycin complex-1 (mTORC1) signaling yet induce effector T (T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b959fa7ccf9ba7a8d9befc951ee84617
https://pubmed.ncbi.nlm.nih.gov/36076931
https://pubmed.ncbi.nlm.nih.gov/36076931
Autor:
Jennifer N. K. Nyarko, Carlos E. de Carvalho, Kaeli J. Knudsen, Paul R. Pennington, Maria A. C. Bolanos, Matthew P. Parsons, Darrell D. Mousseau, Josef Buttigieg, Jocelyn R. Barnes, Ryan M. Heistad, Scot C. Leary, Maa O. Quartey, Jason Maley
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Scientific Reports
Scientific Reports
The pool of β-Amyloid (Aβ) length variants detected in preclinical and clinical Alzheimer disease (AD) samples suggests a diversity of roles for Aβ peptides. We examined how a naturally occurring variant, e.g. Aβ(1–38), interacts with the AD-re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea510b7f513abcdcbeb17133b2d42130
https://doaj.org/article/986c73bc802940a9ae4cdf2d043e1a43
https://doaj.org/article/986c73bc802940a9ae4cdf2d043e1a43
Autor:
Scot C. Leary, Martina Ralle
Publikováno v:
Curr Opin Chem Biol
Synchrotron-based X-ray fluorescence microscopy (XFM) has become an important imaging technique to investigate elemental concentrations and distributions in biological specimens. Advances in technology now permit imaging at resolutions rivaling that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55aa117719779f901c5d6f594a2399de
https://doi.org/10.1016/j.cbpa.2019.12.002
https://doi.org/10.1016/j.cbpa.2019.12.002