Výsledky vyhledávání - "Scot A Wolfe"

Akademický článek

Correction: The Dkk3 gene encodes a vital intracellular regulator of cell proliferation.

Autor: Jack L Leonard, Deborah M Leonard, Scot A Wolfe, Jilin Liu, Jaime Rivera, Michelle Yang, Ryan T Leonard, Jacob P S Johnson, Prashant Kumar, Kate L Liebmann, Amanda A Tutto, Zhongming Mou, Karl J Simin

Publikováno v: PLoS ONE, Vol 12, Iss 9, p e0184458 (2017)

[This corrects the article DOI: 10.1371/journal.pone.0181724.].

Externí odkaz: https://doaj.org/article/bbf9eb4f25cb452ba73c52962bc98659

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Akademický článek

The Dkk3 gene encodes a vital intracellular regulator of cell proliferation.

Publikováno v: PLoS ONE, Vol 12, Iss 7, p e0181724 (2017)

Members of the Dickkopf (Dkk) family of Wnt antagonists interrupt Wnt-induced receptor assembly and participate in axial patterning and cell fate determination. One family member, DKK3, does not block Wnt receptor activation. Loss of Dkk3 expression

Externí odkaz: https://doaj.org/article/314b504f6fa84f28abb31e68d7b35583

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Akademický článek

Computational identification of diverse mechanisms underlying transcription factor-DNA occupancy.

Autor: Qiong Cheng, Majid Kazemian, Hannah Pham, Charles Blatti, Susan E Celniker, Scot A Wolfe, Michael H Brodsky, Saurabh Sinha

Publikováno v: PLoS Genetics, Vol 9, Iss 8, p e1003571 (2013)

ChIP-based genome-wide assays of transcription factor (TF) occupancy have emerged as a powerful, high-throughput method to understand transcriptional regulation, especially on a global scale. This has led to great interest in the underlying biochemic

Externí odkaz: https://doaj.org/article/85068967f9a24538805497de4fa60eba

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Akademický článek

Quantitative analysis of the Drosophila segmentation regulatory network using pattern generating potentials.

Autor: Majid Kazemian, Charles Blatti, Adam Richards, Michael McCutchan, Noriko Wakabayashi-Ito, Ann S Hammonds, Susan E Celniker, Sudhir Kumar, Scot A Wolfe, Michael H Brodsky, Saurabh Sinha

Publikováno v: PLoS Biology, Vol 8, Iss 8, p e1000456 (2010)

Cis-regulatory modules that drive precise spatial-temporal patterns of gene expression are central to the process of metazoan development. We describe a new computational strategy to annotate genomic sequences based on their "pattern generating poten

Externí odkaz: https://doaj.org/article/8623d3269ad24e4f923079e9b1f726d1

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Akademický článek

Pre-existing immunity does not impair the engraftment of CRISPR-Cas9-edited cells in rhesus macaques conditioned with busulfan or radiation

Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 29, Iss , Pp 483-493 (2023)

CRISPR-Cas9-based therapeutic genome editing approaches hold promise to cure a variety of human diseases. Recent findings demonstrate pre-existing immunity for the commonly used Cas orthologs from Streptococcus pyogenes (SpCas9) and Staphylococcus au

Externí odkaz: https://doaj.org/article/186bb2a612c54f99a14f07e9473590ec

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Akademický článek

Crosstalk between corepressor NRIP1 and cAMP signaling on adipocyte thermogenic programming

Autor: Emmanouela Tsagkaraki, Adilson Guilherme, Sarah M. Nicoloro, Mark Kelly, Lawrence M. Lifshitz, Hui Wang, Kyounghee Min, Leslie A. Rowland, Kaltinaitis B. Santos, Nicole Wetoska, Randall H. Friedline, Stacy A. Maitland, Min Chen, Lee S. Weinstein, Scot A. Wolfe, Jason K. Kim, Michael P. Czech

Publikováno v: Molecular Metabolism, Vol 76, Iss , Pp 101780- (2023)

Objectives: Nuclear receptor interacting protein 1 (NRIP1) suppresses energy expenditure via repression of nuclear receptors, and its depletion markedly elevates uncoupled respiration in mouse and human adipocytes. We tested whether NRIP1 deficient a

Externí odkaz: https://doaj.org/article/8509853fb6d444bb83dafa8e5ebf8337

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Akademický článek

Genome editing of HBG1 and HBG2 to induce fetal hemoglobin

Publikováno v: Blood Advances, Vol 3, Iss 21, Pp 3379-3392 (2019)

Abstract: Induction of fetal hemoglobin (HbF) via clustered regularly interspaced short palindromic repeats/Cas9–mediated disruption of DNA regulatory elements that repress γ-globin gene (HBG1 and HBG2) expression is a promising therapeutic strate

Externí odkaz: https://doaj.org/article/d8bdc8c4db524cf3ab90d0385b570174

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Efficient Homology-Directed Repair with Circular Single-Stranded DNA Donors

Autor: Sukanya Iyer, Aamir Mir, Joel Vega-Badillo, Benjamin P. Roscoe, Raed Ibraheim, Lihua Julie Zhu, Jooyoung Lee, Pengpeng Liu, Kevin Luk, Esther Mintzer, Dongsheng Guo, Josias Soares de Brito, Charles P. Emerson, Phillip D. Zamore, Erik J. Sontheimer, Scot A. Wolfe

Publikováno v: The CRISPR Journal. 5:685-701

While genome editing has been revolutionized by the advent of CRISPR-based nucleases, difficulties in achieving efficient, nuclease-mediated, homology-directed repair (HDR) still limit many applications. Commonly used DNA donors such as plasmids suff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2676939cee7f1aebba005624d2b76eb9
https://doi.org/10.1089/crispr.2022.0058

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Adenine Base Editing In Vivo with a Single Adeno-Associated Virus Vector

Autor: Han Zhang, Nathan Bamidele, Pengpeng Liu, Ogooluwa Ojelabi, Xin D. Gao, Tomás Rodriguez, Haoyang Cheng, Karen Kelly, Jonathan K. Watts, Jun Xie, Guangping Gao, Scot A. Wolfe, Wen Xue, Erik J. Sontheimer

Publikováno v: GEN Biotechnol

Base editors (BEs) have opened new avenues for the treatment of genetic diseases. However, advances in delivery approaches are needed to enable disease targeting of a broad range of tissues and cell types. Adeno-associated virus (AAV) vectors remain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::020b9a5b112732deb4f7b4299e1128a4
https://doi.org/10.1089/genbio.2022.0015

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