The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K.

Autor: Bushell SR; Structural Genomics Consortium, Nuffield Department of Medicine, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ, UK., Pike ACW; Structural Genomics Consortium, Nuffield Department of Medicine, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ, UK., Falzone ME; Department of Biochemistry, Weill Cornell Medical School, 1300 York Avenue, New York, NY, 10065, USA., Rorsman NJG; Department of Pharmacology, University of Oxford, Mansfield Road, Oxford, OX1 3QT, UK.; OxSyBio, Atlas Building, Harwell Campus, Didcot, Oxfordshire, OX11 0QX, UK., Ta CM; Department of Pharmacology, University of Oxford, Mansfield Road, Oxford, OX1 3QT, UK.; Department of Cardiology, Washington University in St. Louis, St. Louis, MO, 63110, USA., Corey RA; Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QT, UK., Newport TD; Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QT, UK.; Oxford Nanopore Technologies, Oxford Science Park, Oxford, OX4 4DQ, UK., Christianson JC; Nuffield Department of Rheumatology, Orthopaedics and Musculoskeletal Sciences, University of Oxford, Windmill Road, Oxford, OX3 7LD, UK., Scofano LF; Department of Pharmacology, University of Oxford, Mansfield Road, Oxford, OX1 3QT, UK., Shintre CA; Structural Genomics Consortium, Nuffield Department of Medicine, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ, UK.; Vertex Pharmaceuticals Ltd, Milton Park, Oxfordshire, OX14 4RW, UK., Tessitore A; Structural Genomics Consortium, Nuffield Department of Medicine, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ, UK.; Nuffield Division of Clinical Laboratory Sciences, Oxford University, Oxford, OX3 9DU, UK., Chu A; Structural Genomics Consortium, Nuffield Department of Medicine, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ, UK.; Department of Biochemistry, Oxford University, Oxford, OX1 3QT, UK., Wang Q; Structural Genomics Consortium, Nuffield Department of Medicine, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ, UK.; Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QT, UK., Shrestha L; Structural Genomics Consortium, Nuffield Department of Medicine, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ, UK., Mukhopadhyay SMM; Structural Genomics Consortium, Nuffield Department of Medicine, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ, UK., Love JD; Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY, 10461-1602, USA.; Novo Nordisk A/S, Novo Nordisk Park, 2760, Måløv, Denmark., Burgess-Brown NA; Structural Genomics Consortium, Nuffield Department of Medicine, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ, UK., Sitsapesan R; Department of Pharmacology, University of Oxford, Mansfield Road, Oxford, OX1 3QT, UK., Stansfeld PJ; Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QT, UK., Huiskonen JT; Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK., Tammaro P; Department of Pharmacology, University of Oxford, Mansfield Road, Oxford, OX1 3QT, UK., Accardi A; Department of Biochemistry, Weill Cornell Medical School, 1300 York Avenue, New York, NY, 10065, USA.; Department of Anesthesiology, Weill Cornell Medical School, 25 East 68th Street, New York, NY, 10065, USA.; Department of Physiology and Biophysics, Weill Cornell Medical School, 1300 York Avenue, New York, NY, 10065, USA., Carpenter EP; Structural Genomics Consortium, Nuffield Department of Medicine, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ, UK. liz.carpenter@sgc.ox.ac.uk.

Publikováno v: Nature communications [Nat Commun] 2019 Sep 02; Vol. 10 (1), pp. 3956. Date of Electronic Publication: 2019 Sep 02.