The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K

Autor: Bushell, Simon R., Pike, Ashley C. W., Falzone, Maria E., Rorsman, Nils J. G., Ta, Chau M., Corey, Robin A., Newport, Thomas D., Christianson, John C., Scofano, Lara F., Shintre, Chitra A., Tessitore, Annamaria, Chu, Amy, Wang, Qinrui, Shrestha, Leela, Mukhopadhyay, Shubhashish M. M., Love, James D., Burgess-Brown, Nicola A., Sitsapesan, Rebecca, Stansfeld, Phillip J., Huiskonen, Juha T., Tammaro, Paolo, Accardi, Alessio, Carpenter, Elisabeth P.

Publikováno v: Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)

Membranes in cells have defined distributions of lipids in each leaflet, controlled by lipid scramblases and flip/floppases. However, for some intracellular membranes such as the endoplasmic reticulum (ER) the scramblases have not been identified. Me

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The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K.

Autor: Bushell SR; Structural Genomics Consortium, Nuffield Department of Medicine, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ, UK., Pike ACW; Structural Genomics Consortium, Nuffield Department of Medicine, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ, UK., Falzone ME; Department of Biochemistry, Weill Cornell Medical School, 1300 York Avenue, New York, NY, 10065, USA., Rorsman NJG; Department of Pharmacology, University of Oxford, Mansfield Road, Oxford, OX1 3QT, UK.; OxSyBio, Atlas Building, Harwell Campus, Didcot, Oxfordshire, OX11 0QX, UK., Ta CM; Department of Pharmacology, University of Oxford, Mansfield Road, Oxford, OX1 3QT, UK.; Department of Cardiology, Washington University in St. Louis, St. Louis, MO, 63110, USA., Corey RA; Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QT, UK., Newport TD; Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QT, UK.; Oxford Nanopore Technologies, Oxford Science Park, Oxford, OX4 4DQ, UK., Christianson JC; Nuffield Department of Rheumatology, Orthopaedics and Musculoskeletal Sciences, University of Oxford, Windmill Road, Oxford, OX3 7LD, UK., Scofano LF; Department of Pharmacology, University of Oxford, Mansfield Road, Oxford, OX1 3QT, UK., Shintre CA; Structural Genomics Consortium, Nuffield Department of Medicine, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ, UK.; Vertex Pharmaceuticals Ltd, Milton Park, Oxfordshire, OX14 4RW, UK., Tessitore A; Structural Genomics Consortium, Nuffield Department of Medicine, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ, UK.; Nuffield Division of Clinical Laboratory Sciences, Oxford University, Oxford, OX3 9DU, UK., Chu A; Structural Genomics Consortium, Nuffield Department of Medicine, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ, UK.; Department of Biochemistry, Oxford University, Oxford, OX1 3QT, UK., Wang Q; Structural Genomics Consortium, Nuffield Department of Medicine, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ, UK.; Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QT, UK., Shrestha L; Structural Genomics Consortium, Nuffield Department of Medicine, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ, UK., Mukhopadhyay SMM; Structural Genomics Consortium, Nuffield Department of Medicine, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ, UK., Love JD; Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY, 10461-1602, USA.; Novo Nordisk A/S, Novo Nordisk Park, 2760, Måløv, Denmark., Burgess-Brown NA; Structural Genomics Consortium, Nuffield Department of Medicine, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ, UK., Sitsapesan R; Department of Pharmacology, University of Oxford, Mansfield Road, Oxford, OX1 3QT, UK., Stansfeld PJ; Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QT, UK., Huiskonen JT; Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK., Tammaro P; Department of Pharmacology, University of Oxford, Mansfield Road, Oxford, OX1 3QT, UK., Accardi A; Department of Biochemistry, Weill Cornell Medical School, 1300 York Avenue, New York, NY, 10065, USA.; Department of Anesthesiology, Weill Cornell Medical School, 25 East 68th Street, New York, NY, 10065, USA.; Department of Physiology and Biophysics, Weill Cornell Medical School, 1300 York Avenue, New York, NY, 10065, USA., Carpenter EP; Structural Genomics Consortium, Nuffield Department of Medicine, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ, UK. liz.carpenter@sgc.ox.ac.uk.

Publikováno v: Nature communications [Nat Commun] 2019 Sep 02; Vol. 10 (1), pp. 3956. Date of Electronic Publication: 2019 Sep 02.