Systematic genetic characterization of the human PKR kinase domain highlights its functional malleability to escape a poxvirus substrate mimic.

Autor: Chambers MJ; Center for Genomics and Data Science Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA.; Department of Microbiology & Immunology, Georgetown University, Washington DC, USA., Scobell SB; Center for Genomics and Data Science Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA., Sadhu MJ; Center for Genomics and Data Science Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Sep 22. Date of Electronic Publication: 2024 Sep 22.