A role for Schwann cell-derived neuregulin-1 in remyelination

Autor: Viktorija Velanac, Michael W. Sereda, Ruth M. Stassart, Dies Meijer, Markus H. Schwab, Bastian G. Brinkmann, Klaus-Armin Nave, Robert Fledrich

Publikováno v: Nature Neuroscience; Vol 16
Nature reviews / Neuroscience 16(1), 48-54 (2012). doi:10.1038/nn.3281
Nature Neuroscience, 16(1), 48-U76. Nature Publishing Group

After peripheral nerve injury, axons regenerate and become remyelinated by resident Schwann cells. However, myelin repair never results in the original myelin thickness, suggesting insufficient stimulation by neuronal growth factors. Upon testing thi

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