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Simultaneous Exposure to Intracellular and Extracellular Photosensitizers for the Treatment of Staphylococcus aureus Infections.

Autor: Drury SL; Department of Pathology, Microbiology and Immunology, Vanderbilt Universitygrid.152326.1grid.412807.8grid.152326.1grid.412807.8 Medical Center, Nashville, Tennessee, USA., Miller AR; Department of Pathology, Microbiology and Immunology, Vanderbilt Universitygrid.152326.1grid.412807.8grid.152326.1grid.412807.8 Medical Center, Nashville, Tennessee, USA., Laut CL; Department of Pathology, Microbiology and Immunology, Vanderbilt Universitygrid.152326.1grid.412807.8grid.152326.1grid.412807.8 Medical Center, Nashville, Tennessee, USA.; Vanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt Universitygrid.152326.1grid.412807.8grid.152326.1grid.412807.8 Medical Center, Nashville, Tennessee, USA., Walter AB; Department of Biomedical Engineering, Vanderbilt Universitygrid.152326.1grid.412807.8grid.152326.1grid.412807.8, Nashville, Tennessee, USA.; Vanderbilt Biophotonics Center, Vanderbilt Universitygrid.152326.1grid.412807.8grid.152326.1grid.412807.8, Nashville, Tennessee, USA., Bennett MR; Department of Pathology, Microbiology and Immunology, Vanderbilt Universitygrid.152326.1grid.412807.8grid.152326.1grid.412807.8 Medical Center, Nashville, Tennessee, USA.; Vanderbilt Vaccine Center, Vanderbilt Universitygrid.152326.1grid.412807.8grid.152326.1grid.412807.8 Medical Center, Nashville, Tennessee, USA., Su M; Vanderbilt University Institute of Imaging Science, Vanderbilt Universitygrid.152326.1grid.412807.8grid.152326.1grid.412807.8Vanderbilt University Institute of Imaging Science, grid.152326.1grid.412807.8grid.152326.1grid.412807.8, Nashville, Tennessee, USA., Bai M; Vanderbilt University Institute of Imaging Science, Vanderbilt Universitygrid.152326.1grid.412807.8grid.152326.1grid.412807.8Vanderbilt University Institute of Imaging Science, grid.152326.1grid.412807.8grid.152326.1grid.412807.8, Nashville, Tennessee, USA.; Department of Radiology and Radiological Sciences, Vanderbilt Universitygrid.152326.1grid.412807.8grid.152326.1grid.412807.8 Medical Center, Nashville, Tennessee, USA.; Vanderbilt Ingram Cancer Center, Vanderbilt Universitygrid.152326.1grid.412807.8grid.152326.1grid.412807.8 Medical Center, Nashville, Tennessee, USA., Jing B; Walter Reed Army Institute of Research, Silver Spring, Maryland, USA., Joseph SB; Walter Reed Army Institute of Research, Silver Spring, Maryland, USA., Metzger EJ; Walter Reed Army Institute of Research, Silver Spring, Maryland, USA., Bane CE; Walter Reed Army Institute of Research, Silver Spring, Maryland, USA., Black CC; Walter Reed Army Institute of Research, Silver Spring, Maryland, USA., Macdonald MT; Walter Reed Army Institute of Research, Silver Spring, Maryland, USA., Dutter BF; Department of Chemical Biology, Vanderbilt Universitygrid.152326.1grid.412807.8grid.152326.1grid.412807.8, Nashville, Tennessee, USA., Romaine IM; Department of Chemical Biology, Vanderbilt Universitygrid.152326.1grid.412807.8grid.152326.1grid.412807.8, Nashville, Tennessee, USA., Waterson AG; Department of Chemical Biology, Vanderbilt Universitygrid.152326.1grid.412807.8grid.152326.1grid.412807.8, Nashville, Tennessee, USA.; Department of Chemistry, Vanderbilt Universitygrid.152326.1grid.412807.8grid.152326.1grid.412807.8, Nashville, Tennessee, USA.; Department of Pharmacology, Vanderbilt Universitygrid.152326.1grid.412807.8grid.152326.1grid.412807.8, Nashville, Tennessee, USA., Sulikowski GA; Department of Chemical Biology, Vanderbilt Universitygrid.152326.1grid.412807.8grid.152326.1grid.412807.8, Nashville, Tennessee, USA.; Department of Chemistry, Vanderbilt Universitygrid.152326.1grid.412807.8grid.152326.1grid.412807.8, Nashville, Tennessee, USA.; Department of Pharmacology, Vanderbilt Universitygrid.152326.1grid.412807.8grid.152326.1grid.412807.8, Nashville, Tennessee, USA., Jansen ED; Department of Biomedical Engineering, Vanderbilt Universitygrid.152326.1grid.412807.8grid.152326.1grid.412807.8, Nashville, Tennessee, USA.; Vanderbilt Biophotonics Center, Vanderbilt Universitygrid.152326.1grid.412807.8grid.152326.1grid.412807.8, Nashville, Tennessee, USA., Crowe JE Jr; Department of Pathology, Microbiology and Immunology, Vanderbilt Universitygrid.152326.1grid.412807.8grid.152326.1grid.412807.8 Medical Center, Nashville, Tennessee, USA.; Vanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt Universitygrid.152326.1grid.412807.8grid.152326.1grid.412807.8 Medical Center, Nashville, Tennessee, USA.; Vanderbilt Vaccine Center, Vanderbilt Universitygrid.152326.1grid.412807.8grid.152326.1grid.412807.8 Medical Center, Nashville, Tennessee, USA.; Department of Pediatrics, Vanderbilt Universitygrid.152326.1grid.412807.8grid.152326.1grid.412807.8 Medical Center, Nashville, Tennessee, USA., Sciotti RJ; Walter Reed Army Institute of Research, Silver Spring, Maryland, USA., Skaar EP; Department of Pathology, Microbiology and Immunology, Vanderbilt Universitygrid.152326.1grid.412807.8grid.152326.1grid.412807.8 Medical Center, Nashville, Tennessee, USA.; Vanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt Universitygrid.152326.1grid.412807.8grid.152326.1grid.412807.8 Medical Center, Nashville, Tennessee, USA.

Publikováno v: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2021 Nov 17; Vol. 65 (12), pp. e0091921. Date of Electronic Publication: 2021 Sep 13.

Chemoprotective antimalarials identified through quantitative high-throughput screening of Plasmodium blood and liver stage parasites.

Autor: Dorjsuren D; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, 20850, USA., Eastman RT; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, 20850, USA., Wicht KJ; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, 10032, USA.; Drug Discovery and Development Centre (H3D), University of Cape Town, Rondebosch, 7701, South Africa., Jansen D; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, 20850, USA., Talley DC; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, 20850, USA., Sigmon BA; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, 20850, USA., Zakharov AV; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, 20850, USA., Roncal N; Experimental Therapeutics Branch, Walter Reed Army Institute of Research, Silver Spring, MD, 20910, USA., Girvin AT; Palantir Technologies, Washington, DC, 20007, USA., Antonova-Koch Y; Department of Pediatrics, Pharmacology and Drug Discovery, School of Medicine, University of California San Diego, La Jolla, CA, 92093, USA.; Calibr, The Scripps Research Institute, La Jolla, CA, 92037, USA., Will PM; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, 20850, USA., Shah P; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, 20850, USA., Sun H; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, 20850, USA., Klumpp-Thomas C; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, 20850, USA., Mok S; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, 10032, USA., Yeo T; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, 10032, USA., Meister S; Department of Pediatrics, Pharmacology and Drug Discovery, School of Medicine, University of California San Diego, La Jolla, CA, 92093, USA.; Beckman Coulter Inc., Carlsbad, CA, 92010, USA., Marugan JJ; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, 20850, USA., Ross LS; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, 10032, USA., Xu X; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, 20850, USA., Maloney DJ; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, 20850, USA.; Veralox Therapeutics Inc., Frederick, MD, 21704, USA., Jadhav A; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, 20850, USA., Mott BT; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, 20850, USA., Sciotti RJ; Experimental Therapeutics Branch, Walter Reed Army Institute of Research, Silver Spring, MD, 20910, USA., Winzeler EA; Department of Pediatrics, Pharmacology and Drug Discovery, School of Medicine, University of California San Diego, La Jolla, CA, 92093, USA., Waters NC; Experimental Therapeutics Branch, Walter Reed Army Institute of Research, Silver Spring, MD, 20910, USA., Campbell RF; Experimental Therapeutics Branch, Walter Reed Army Institute of Research, Silver Spring, MD, 20910, USA., Huang W; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, 20850, USA., Simeonov A; Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, 20850, USA. asimeono@mail.nih.gov., Fidock DA; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, NY, 10032, USA. df2260@cumc.columbia.edu.; Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, NY, 10032, USA. df2260@cumc.columbia.edu.

Publikováno v: Scientific reports [Sci Rep] 2021 Jan 22; Vol. 11 (1), pp. 2121. Date of Electronic Publication: 2021 Jan 22.