Zobrazeno 1 - 10
of 193
pro vyhledávání: '"Scid-X1"'
Autor:
Charles C. Berry, Christopher Nobles, Emmanuelle Six, Yinghua Wu, Nirav Malani, Eric Sherman, Anatoly Dryga, John K. Everett, Frances Male, Aubrey Bailey, Kyle Bittinger, Mary J. Drake, Laure Caccavelli, Paul Bates, Salima Hacein-Bey-Abina, Marina Cavazzana, Frederic D. Bushman
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 4, Iss C, Pp 17-26 (2017)
Analysis of sites of newly integrated DNA in cellular genomes is important to several fields, but methods for analyzing and visualizing these datasets are still under development. Here, we describe tools for data analysis and visualization that take
Externí odkaz:
https://doaj.org/article/f6f59b94b4594769ac2569d51c8c88e1
Autor:
Eric Sherman, Christopher Nobles, Charles C. Berry, Emmanuelle Six, Yinghua Wu, Anatoly Dryga, Nirav Malani, Frances Male, Shantan Reddy, Aubrey Bailey, Kyle Bittinger, John K. Everett, Laure Caccavelli, Mary J. Drake, Paul Bates, Salima Hacein-Bey-Abina, Marina Cavazzana, Frederic D. Bushman
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 4, Iss C, Pp 39-49 (2017)
Integration of new DNA into cellular genomes mediates replication of retroviruses and transposons; integration reactions have also been adapted for use in human gene therapy. Tracking the distributions of integration sites is important to characteriz
Externí odkaz:
https://doaj.org/article/3427f2d0dfcc4d91928bb6ad271ea637
Autor:
Anatoly Dryga, Emmanuelle Six, Yinghua Wu, Mary Jane Drake, Christopher L. Nobles, Eric J. Sherman, Aubrey Bailey, Laure Caccavelli, Nirav Malani, Paul Bates, Salima Hacein-Bey-Abina, Frances Male, Frederic D. Bushman, Shantan Reddy, Marina Cavazzana, Charles C. Berry, John K. Everett, Kyle Bittinger
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 4, Iss C, Pp 39-49 (2017)
Molecular Therapy. Methods & Clinical Development
Sherman, E; Nobles, C; Berry, CC; Six, E; Wu, Y; Dryga, A; et al.(2017). INSPIIRED: A Pipeline for Quantitative Analysis of Sites of New DNA Integration in Cellular Genomes. MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT, 4, 39-49. doi: 10.1016/j.omtm.2016.11.002. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/2tq50500
Molecular Therapy. Methods & Clinical Development
Sherman, E; Nobles, C; Berry, CC; Six, E; Wu, Y; Dryga, A; et al.(2017). INSPIIRED: A Pipeline for Quantitative Analysis of Sites of New DNA Integration in Cellular Genomes. MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT, 4, 39-49. doi: 10.1016/j.omtm.2016.11.002. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/2tq50500
Integration of new DNA into cellular genomes mediates replication of retroviruses and transposons; integration reactions have also been adapted for use in human gene therapy. Tracking the distributions of integration sites is important to characteriz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbdf7982cad42256726d2cbc46a1b137
http://www.sciencedirect.com/science/article/pii/S2329050116301309
http://www.sciencedirect.com/science/article/pii/S2329050116301309
Autor:
Erdahl Teber, Hong Ching Lee, Jonathan W. Arthur, Sophia H.Y. Liao, Adrian J. Thrasher, Claus V. Hallwirth, Stephen I. Alexander, Roger R. Reddel, Szun S. Tay, Ian E. Alexander, Jianmin Wu, Matthew P. McCormack, Samantha L. Ginn, Marina Cavazzana, Min Hu
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 6, Iss, Pp 1-14 (2017)
Molecular Therapy. Nucleic Acids
Molecular Therapy. Nucleic Acids
In early gene therapy trials for SCID-X1, using γ-retroviral vectors, T cell leukemias developed in a subset of patients secondary to insertional proto-oncogene activation. In contrast, we have reported development of T cell leukemias in SCID-X1 mic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::951af17b8f80b85ccf8649c2569d478f
http://www.sciencedirect.com/science/article/pii/S2162253116303705
http://www.sciencedirect.com/science/article/pii/S2162253116303705
Akademický článek
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Akademický článek
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Publikováno v:
Viruses
Foamy viruses (FVs) are nonpathogenic retroviruses that infect various animals including bovines, felines, nonhuman primates (NHPs), and can be transmitted to humans through zoonotic infection. Due to their non-pathogenic nature, broad tissue tropism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01d76a5b2375001b7ffec7d5abd1bccd
https://doi.org/10.3390/v11121091
https://doi.org/10.3390/v11121091
Akademický článek
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Autor:
Sayandip Mukherjee, Adrian J. Thrasher
Publikováno v:
Gene
Gene; Vol 525
Gene; Vol 525
Substantial progress has been made in the past decade in treating several primary immunodeficiency disorders (PIDs) with gene therapy. Current approaches are based on ex-vivo transfer of therapeutic transgene via viral vectors to patient-derived auto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d90bb8143387c882595f8cb2bb2b67e
Autor:
Nirav Malani, Aubrey Bailey, Kyle Bittinger, Salima Hacein-Bey-Abina, Frances Male, Marina Cavazzana, Charles C. Berry, Laure Caccavelli, Frederic D. Bushman, Mary Jane Drake, Emmanuelle Six, Yinghua Wu, Paul Bates, Christopher L. Nobles, Eric J. Sherman, Anatoly Dryga, John K. Everett
Publikováno v:
Molecular Therapy. Methods & Clinical Development
Molecular Therapy: Methods & Clinical Development, Vol 4, Iss C, Pp 17-26 (2017)
Berry, CC; Nobles, C; Six, E; Wu, Y; Malani, N; Sherman, E; et al.(2017). INSPIIRED: Quantification and Visualization Tools for Analyzing Integration Site Distributions. MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT, 4, 17-26. doi: 10.1016/j.omtm.2016.11.003. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/1z88x22p
Molecular Therapy: Methods & Clinical Development, Vol 4, Iss C, Pp 17-26 (2017)
Berry, CC; Nobles, C; Six, E; Wu, Y; Malani, N; Sherman, E; et al.(2017). INSPIIRED: Quantification and Visualization Tools for Analyzing Integration Site Distributions. MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT, 4, 17-26. doi: 10.1016/j.omtm.2016.11.003. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/1z88x22p
Analysis of sites of newly integrated DNA in cellular genomes is important to several fields, but methods for analyzing and visualizing these datasets are still under development. Here, we describe tools for data analysis and visualization that take
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27c22c2aa171def36fc0e67010770679
https://pubmed.ncbi.nlm.nih.gov/28344988
https://pubmed.ncbi.nlm.nih.gov/28344988