A Continuous Intestinal Absorption Model to Predict Drug Enterohepatic Recirculation in Healthy Humans: Nalbuphine as a Model Substrate.

Autor: Korzekwa K; Department of Pharmaceutical Sciences, Temple University School of Pharmacy, 3307 N Broad Street, Philadelphia, Pennsylvania 19140, United States., Nagar S; Department of Pharmaceutical Sciences, Temple University School of Pharmacy, 3307 N Broad Street, Philadelphia, Pennsylvania 19140, United States., Clark D; Trevi Therapeutics, 195 Church Street 16th Floor, New Haven, Connecticut 06510, United States., Sciascia T; Trevi Therapeutics, 195 Church Street 16th Floor, New Haven, Connecticut 06510, United States., Hawi A; A. Hawi Consulting, 35 New Street, Ridgefield, Connecticut 06877, United States.

Publikováno v: Molecular pharmaceutics [Mol Pharm] 2024 Sep 02; Vol. 21 (9), pp. 4510-4523. Date of Electronic Publication: 2024 Jul 02.

A population pharmacokinetic-pharmacodynamic model evaluating efficacy of nalbuphine extended-release in patients with prurigo nodularis.

Autor: Eudy-Byrne R; Metrum Research Group, Tariffville, CT, USA., Riggs M; Metrum Research Group, Tariffville, CT, USA., Hawi A; A. Hawi Consulting, Ridgefield, CT, USA., Sciascia T; Trevi Therapeutics, New Haven, CT, USA., Rohatagi S; Trevi Therapeutics, New Haven, CT, USA.

Publikováno v: British journal of clinical pharmacology [Br J Clin Pharmacol] 2023 Jul; Vol. 89 (7), pp. 2088-2101. Date of Electronic Publication: 2023 Feb 09.

Nalbuphine Tablets for Cough in Patients with Idiopathic Pulmonary Fibrosis.

Autor: Maher TM; Keck School of Medicine, University of Southern California, Los Angeles.; National Heart and Lung Institute, Imperial College London, London., Avram C; Northwest Interstitial Lung Disease Unit, Manchester University NHS Foundation Trust, Manchester, United Kingdom., Bortey E; Pharmaceutical Development Strategies, LLC, Chapel Hill, NC., Hart SP; University of Hull, Hull, United Kingdom., Hirani N; Centre for Inflammation Research, University of Edinburgh, Edinburgh., Molyneux PL; National Heart and Lung Institute, Imperial College London, London., Porter JC; UCL Respiratory, University College London, London.; ILD Service, University College London Hospitals, London., Smith JA; Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, University of Manchester, Manchester, United Kingdom., Sciascia T; Trevi Therapeutics, New Haven, CT.

Publikováno v: NEJM evidence [NEJM Evid] 2023 Aug; Vol. 2 (8), pp. EVIDoa2300083. Date of Electronic Publication: 2023 May 22.

Role of kappa-opioid and mu-opioid receptors in pruritus: Peripheral and central itch circuits.

Autor: Kim BS; Kimberly and Eric J. Waldman Department of Dermatology, Mark Lebwohl Center for Neuroinflammation and Sensation, Marc and Jennifer Lipschultz Precision Immunology Institute, and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA., Inan S; Center for Substance Abuse Research, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania, USA., Ständer S; Department of Dermatology and Center for Chronic Pruritus, University Hospital Műnster, Műnster, Germany., Sciascia T; Trevi Therapeutics, Inc., New Haven, Connecticut, USA., Szepietowski JC; Department of Dermatology, Venereology, and Allergology, Wroclaw Medical University, Wroclaw, Poland., Yosipovitch G; Dr Phillip Frost Department of Dermatology and Cutaneous Surgery, Miami Itch Center, Miller School of Medicine, University of Miami, Miami, Florida, USA.

Publikováno v: Experimental dermatology [Exp Dermatol] 2022 Dec; Vol. 31 (12), pp. 1900-1907. Date of Electronic Publication: 2022 Sep 23.

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