Allosteric regulation within the highly interconnected structural scaffold of AraC/XylS homologs tolerates a wide range of amino acid changes.

Autor: Picard HR; Department of Biochemistry and Molecular Biology, The University of Kansas Medical Center, Kansas City, Kansas, USA., Schwingen KS; Department of Biochemistry and Molecular Biology, The University of Kansas Medical Center, Kansas City, Kansas, USA., Green LM; Department of Biochemistry and Molecular Biology, The University of Kansas Medical Center, Kansas City, Kansas, USA., Shis DL; Department of Biosciences, Rice University, Houston, Texas, USA.; Department of Bioengineering, Rice University, Houston, Texas, USA., Egan SM; Department of Molecular Biosciences, The University of Kansas, Lawrence, Kansas, USA., Bennett MR; Department of Biosciences, Rice University, Houston, Texas, USA.; Department of Bioengineering, Rice University, Houston, Texas, USA., Swint-Kruse L; Department of Biochemistry and Molecular Biology, The University of Kansas Medical Center, Kansas City, Kansas, USA.

Publikováno v: Proteins [Proteins] 2022 Jan; Vol. 90 (1), pp. 186-199. Date of Electronic Publication: 2021 Aug 16.