Mechanisms and Barriers in Nanomedicine: Progress in the Field and Future Directions.

Autor: Anchordoquy T; Department of Pharmaceutical Sciences, The Skaggs School of Pharmacy and Pharmaceutical Sciences, the University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045, United States., Artzi N; Brigham and Woman's Hospital, Department of Medicine, Division of Engineering in Medicine, Harvard Medical School, Boston, Massachusetts 02215, United States.; Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, Massachusetts 02215, United States.; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts 02215, United States., Balyasnikova IV; Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University; Northwestern Medicine Malnati Brain Tumor Institute of the Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, United States., Barenholz Y; Membrane and Liposome Research Lab, IMRIC, Hebrew University Hadassah Medical School, Jerusalem 9112102, Israel., La-Beck NM; Department of Immunotherapeutics and Biotechnology, Jerry H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, Abilene, Texas 79601, United States., Brenner JS; Departments of Medicine and Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States., Chan WCW; Institute of Biomedical Engineering, University of Toronto, Rosebrugh Building, 164 College Street, Toronto, Ontario M5S 3G9, Canada.; Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada., Decuzzi P; Laboratory of Nanotechnology for Precision Medicine, Italian Institute of Technology, 16163 Genova, Italy., Exner AA; Departments of Radiology and Biomedical Engineering, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, United States., Gabizon A; The Helmsley Cancer Center, Shaare Zedek Medical Center and The Hebrew University of Jerusalem-Faculty of Medicine, Jerusalem, 9103102, Israel., Godin B; Department of Nanomedicine, Houston Methodist Research Institute, Houston, Texas 77030, United States.; Department of Obstetrics and Gynecology, Houston Methodist Hospital, Houston, Texas 77030, United States.; Department of Obstetrics and Gynecology, Weill Cornell Medicine College (WCMC), New York, New York 10065, United States.; Department of Biomedical Engineering, Texas A&M, College Station, Texas 7784,3 United States., Lai SK; Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina 27599, United States., Lammers T; Department of Nanomedicine and Theranostics, Institute for Experimental Molecular Imaging, Center for Biohybrid Medical Systems, University Hospital RWTH Aachen, 52074 Aachen, Germany., Mitchell MJ; Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.; Penn Institute for RNA Innovation, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States., Moghimi SM; School of Pharmacy, Newcastle University, Newcastle upon Tyne NE1 7RU, U.K.; Translational and Clinical Research Institute, Faculty of Health and Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, U.K.; Colorado Center for Nanomedicine and Nanosafety, University of Colorado Anschutz Medical Center, Aurora, Colorado 80045, United States., Muzykantov VR; Department of Systems Pharmacology and Translational Therapeutics, The Perelman School of Medicine, The University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States., Peer D; Laboratory of Precision Nanomedicine, Shmunis School of Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, 69978, Israel.; Department of Materials Sciences and Engineering, Iby and Aladar Fleischman Faculty of Engineering, Tel Aviv University, Tel Aviv, 69978, Israel.; Center for Nanoscience and Nanotechnology, Tel Aviv University, Tel Aviv, 69978, Israel.; Cancer Biology Research Center, Tel Aviv University, Tel Aviv, 69978, Israel., Nguyen J; Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina 27599, United States., Popovtzer R; Faculty of Engineering and the Institute of Nanotechnology & Advanced Materials, Bar-Ilan University, 5290002 Ramat Gan, Israel., Ricco M; Department of Pharmaceutical Sciences, The Skaggs School of Pharmacy and Pharmaceutical Sciences, the University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045, United States., Serkova NJ; Department of Radiology, University of Colorado Cancer Center, Anschutz Medical Campus, Aurora, Colorado 80045, United States., Singh R; Department of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27101, United States.; Atrium Health Wake Forest Baptist Comprehensive Cancer Center, Winston-Salem, North Carolina 27101, United States., Schroeder A; Department of Chemical Engineering, Technion, Israel Institute of Technology, Haifa 32000, Israel., Schwendeman AA; Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48108; Biointerfaces Institute, University of Michigan, Ann Arbor, Michigan 48108, United States., Straehla JP; Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts 02115 United States.; Koch Institute for Integrative Cancer Research at MIT, Cambridge Massachusetts 02139 United States., Teesalu T; Laboratory of Precision and Nanomedicine, Institute of Biomedicine and Translational Medicine, University of Tartu, 50411 Tartu, Estonia., Tilden S; Department of Pharmaceutical Sciences, The Skaggs School of Pharmacy and Pharmaceutical Sciences, the University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045, United States., Simberg D; Department of Pharmaceutical Sciences, The Skaggs School of Pharmacy and Pharmaceutical Sciences, the University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045, United States.

Publikováno v: ACS nano [ACS Nano] 2024 Jun 04; Vol. 18 (22), pp. 13983-13999. Date of Electronic Publication: 2024 May 20.

Streamlining the Characterization of Disulfide Bond Shuffling and Protein Degradation in IgG1 Biopharmaceuticals Under Native and Stressed Conditions.

Autor: Coghlan J; Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, MI, United States., Benet A; Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, MI, United States., Kumaran P; Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, MI, United States., Ford M; MS Bioworks, Ann Arbor, MI, United States., Veale L; Protein Metrics, Cupertino, CA, United States., Skilton SJ; Protein Metrics, Cupertino, CA, United States., Saveliev S; Promega Corporation, Madison, WI, United States., Schwendeman AA; Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, MI, United States.; Biointerfaces Institute, Ann Arbor, MI, United States.

Publikováno v: Frontiers in bioengineering and biotechnology [Front Bioeng Biotechnol] 2022 Mar 14; Vol. 10, pp. 862456. Date of Electronic Publication: 2022 Mar 14 (Print Publication: 2022).