Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Schweitzer, John B."'
Publikováno v:
ETSU Faculty Works.
Glioblastoma (GBM) is the most malignant primary brain tumor without effective therapies. Since bevacizumab was FDA approved for targeting vascular endothelial growth factor receptor 2 (VEGFR2) in adult patients with recurrent GBM, targeted therapy a
Externí odkaz:
https://dc.etsu.edu/etsu-works-2/51
Autor:
Qin, Yuan, Musket, Anna, Kou, Jianqun, Preiszner, Johanna, Tschida, Barbara R., Qin, Anna, Land, Craig A., Staal, Ben, Kang, Liang, Tanner, Kirk, Jiang, Yong, Schweitzer, John B., Largaespada, David A., Xie, Qian
Publikováno v:
ETSU Faculty Works.
BACKGROUND: Aberrant MET receptor tyrosine kinase (RTK) activation leads to invasive tumor growth in different types of cancer. Overexpression of MET and its ligand hepatocyte growth factor (HGF) occurs more frequently in glioblastoma (GBM) than in l
Externí odkaz:
https://dc.etsu.edu/etsu-works-2/38
Localization of NGF Expression in Mouse Spleen and Salivary Gland: Relevance to Pleotropic Functions
Autor:
Britt, Nicholas M., Poston, Megan D., Garbe, Chloe G., Miller, Madeleine K., Peeters, Loren D., Wills, Liza J., Schweitzer, John B., Brown, Russell W., Hoover, Donald B.
Publikováno v:
ETSU Faculty Works.
Our primary goal was to determine if leukocytes are a source of nerve growth factor (NGF) in mouse spleen. Noradrenergic nerves were localized to arteries and white pulp in normal spleens but only to arteries in ultra-immunodeficient R2G2 mice that l
Externí odkaz:
https://dc.etsu.edu/etsu-works-2/34
Autor:
Ozment, Tammy R., Ha, Tuanzhu, Breuel, Kevin F., Ford, Tiffany R., Ferguson, Donald A., Kalbfleisch, John, Schweitzer, John B., Kelley, Jim L., Li, Chuanfu, Williams, David L.
Publikováno v:
ETSU Faculty Works.
Sepsis is a frequent complication in critical illness. The mechanisms that are involved in initiation and propagation of the disease are not well understood. Scavenger receptor A (SRA) is a membrane receptor that binds multiple polyanions such as oxi
Externí odkaz:
https://dc.etsu.edu/etsu-works/16232
https://dc.etsu.edu/cgi/viewcontent.cgi?article=17498&context=etsu-works
https://dc.etsu.edu/cgi/viewcontent.cgi?article=17498&context=etsu-works
Autor:
Hoover, Donald B., Brown, Thomas Christopher, Miller, Madeleine K., Schweitzer, John B., Williams, David L.
Publikováno v:
ETSU Faculty Works.
The spleen is an important site for central regulation of immune function by noradrenergic sympathetic nerves, but little is known about this major region of neuroimmune communication in humans. Experimental studies using animal models have establish
Externí odkaz:
https://dc.etsu.edu/etsu-works/10509
https://dc.etsu.edu/cgi/viewcontent.cgi?article=11775&context=etsu-works
https://dc.etsu.edu/cgi/viewcontent.cgi?article=11775&context=etsu-works
Autor:
Gibson, Jeffrey B., Maxwell, Robert A., Schweitzer, John B., Fabian, Timothy C., Proctor, Kenneth G.
Publikováno v:
ETSU Faculty Works.
The original purpose of this study was to compare initial resuscitation of hemorrhagic hypotension after traumatic brain injury (TBI) with saline and shed blood. Based on those results, the protocol was modified and saline was compared to a blood sub
Externí odkaz:
https://dc.etsu.edu/etsu-works/18999
Autor:
Malhotra, Ajai K., Schweitzer, John B., Fox, Jeri L., Fabian, Timothy C., Proctor, Kenneth G.
Publikováno v:
ETSU Faculty Works.
Background: Previously, we had shown that elevation of cerebral perfusion pressure, using pressors, improved short-term outcomes after traumatic brain injury and hemorrhagic shock in swine. The current study evaluates outcomes after resuscitation wit
Externí odkaz:
https://dc.etsu.edu/etsu-works/18738
Autor:
Hua, Fang, Ma, Jing, Li, Yan, Ha, Tuanzhu, Xia, Yeling, Kelley, Jim, Williams, David L., Browder, I. William, Schweitzer, John B., Li, Chuanfu
Publikováno v:
ETSU Faculty Works.
A reproducible model of global cerebral ischemia in mice is essential for elucidating the molecular mechanism(s) of neuronal damage induced by cerebral ischemia/reperfusion injury. In the present study, we developed a mouse model of transient global
Externí odkaz:
https://dc.etsu.edu/etsu-works/18165
Autor:
Hua, Fang, Ma, Jing, Ha, Tuanzhu, Xia, Yeling, Kelley, Jim, Williams, David L., Kao, Race L., William Browder, I., Schweitzer, John B., Kalbfleisch, John H., Li, Chuanfu
Publikováno v:
ETSU Faculty Works.
Toll-like receptors (TLRs) play a critical role in the induction of innate immune responses which have been implicated in neuronal death induced by global cerebral ischemia/reperfusion (GCI/R). The present study investigated the role and mechanisms-o
Externí odkaz:
https://dc.etsu.edu/etsu-works/17757
Autor:
Ozment-Skelton, Tammy A., Defluiter, Elizabeth A., Ha, Tuanzhu, Li, Chuanfu, Graves, Bridget M., Ferguson, Donald A., Schweitzer, John B., Preizsner, Johanna, Brown, Gordon D., Gordon, Siamon, Kalbfleisch, John H., Williams, David
Publikováno v:
ETSU Faculty Works.
OBJECTIVE:: To examine peripheral leukocyte Dectin-1 regulation in clinically relevant models of fungal and polymicrobial sepsis. DESIGN:: Prospective animal study. SETTING:: University medical school research laboratory. SUBJECTS:: Age, weight, and
Externí odkaz:
https://dc.etsu.edu/etsu-works/17103