Persistence of spike protein at the skull-meninges-brain axis may contribute to the neurological sequelae of COVID-19.

Autor: Rong Z; Institute for Tissue Engineering and Regenerative Medicine (iTERM), Helmholtz Munich, Neuherberg, Germany; Institute for Stroke and Dementia Research (ISD), University Hospital, Ludwig-Maximilians-University Munich, Munich, Germany; Munich Medical Research School (MMRS), Munich, Germany., Mai H; Institute for Tissue Engineering and Regenerative Medicine (iTERM), Helmholtz Munich, Neuherberg, Germany; Institute for Stroke and Dementia Research (ISD), University Hospital, Ludwig-Maximilians-University Munich, Munich, Germany; Department of Neurology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, China; Munich Medical Research School (MMRS), Munich, Germany., Ebert G; Institute of Virology, Technical University of Munich/Helmholtz Munich, Munich, Germany; German Center for Infection Research (DZIF), Munich Partner Site, Munich, Germany., Kapoor S; Institute for Tissue Engineering and Regenerative Medicine (iTERM), Helmholtz Munich, Neuherberg, Germany; Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA., Puelles VG; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark; Department of Pathology, Aarhus University Hospital, Aarhus, Denmark., Czogalla J; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Hu S; Institute for Stroke and Dementia Research (ISD), University Hospital, Ludwig-Maximilians-University Munich, Munich, Germany., Su J; Institute of Virology, Technical University of Munich/Helmholtz Munich, Munich, Germany., Prtvar D; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany., Singh I; Research Unit Adipocytes & Metabolism (ADM), Helmholtz Diabetes Center, Helmholtz Munich, 85764 Neuherberg, Germany; German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany., Schädler J; Institute of Legal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Delbridge C; Institute of Pathology, Division of Neuropathology, School of Medicine, Technical University of Munich, Munich, Germany., Steinke H; Institute of Anatomy, University of Leipzig, Leipzig, Germany., Frenzel H; Institute of Anatomy, University of Leipzig, Leipzig, Germany., Schmidt K; Institute of Anatomy, University of Leipzig, Leipzig, Germany., Braun C; Institute of Legal Medicine, Ludwig-Maximilians-University Munich, Munich, Germany., Bruch G; Institute of Legal Medicine, Ludwig-Maximilians-University Munich, Munich, Germany., Ruf V; Center for Neuropathology and Prion Research, Ludwig-Maximilians-University Munich, Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany., Ali M; Institute for Tissue Engineering and Regenerative Medicine (iTERM), Helmholtz Munich, Neuherberg, Germany; Graduate School of Neuroscience (GSN), Munich, Germany., Sühs KW; Department of Neurology, Medical School Hannover, Hannover, Germany., Nemati M; Department of Neurology, Ludwig-Maximilians-University Munich, Munich, Germany., Hopfner F; Department of Neurology, Ludwig-Maximilians-University Munich, Munich, Germany., Ulukaya S; Institute for Tissue Engineering and Regenerative Medicine (iTERM), Helmholtz Munich, Neuherberg, Germany., Jeridi D; Institute for Tissue Engineering and Regenerative Medicine (iTERM), Helmholtz Munich, Neuherberg, Germany., Mistretta D; Institute of Virology, Technical University of Munich/Helmholtz Munich, Munich, Germany., Caliskan ÖS; Institute for Diabetes and Obesity, Helmholtz Munich, Neuherberg, Germany., Wettengel JM; Institute of Virology, Technical University of Munich/Helmholtz Munich, Munich, Germany., Cherif F; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany., Kolabas ZI; Institute for Tissue Engineering and Regenerative Medicine (iTERM), Helmholtz Munich, Neuherberg, Germany; Institute for Stroke and Dementia Research (ISD), University Hospital, Ludwig-Maximilians-University Munich, Munich, Germany; Graduate School of Neuroscience (GSN), Munich, Germany., Molbay M; Institute for Tissue Engineering and Regenerative Medicine (iTERM), Helmholtz Munich, Neuherberg, Germany; Institute for Stroke and Dementia Research (ISD), University Hospital, Ludwig-Maximilians-University Munich, Munich, Germany; Munich Medical Research School (MMRS), Munich, Germany., Horvath I; Institute for Tissue Engineering and Regenerative Medicine (iTERM), Helmholtz Munich, Neuherberg, Germany; Center of Doctoral Studies in Informatics and its Applications (CEDOSIA), Technical University of Munich, Munich, Germany., Zhao S; Institute for Tissue Engineering and Regenerative Medicine (iTERM), Helmholtz Munich, Neuherberg, Germany; Institute for Stroke and Dementia Research (ISD), University Hospital, Ludwig-Maximilians-University Munich, Munich, Germany., Krahmer N; Institute for Diabetes and Obesity, Helmholtz Munich, Neuherberg, Germany., Yildirim AÖ; Institute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center (CPC), Helmholtz Munich, Member of the German Center for Lung Research (DZL), Munich, Germany., Ussar S; Research Unit Adipocytes & Metabolism (ADM), Helmholtz Diabetes Center, Helmholtz Munich, 85764 Neuherberg, Germany; German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany., Herms J; Center for Neuropathology and Prion Research, Ludwig-Maximilians-University Munich, Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany., Huber TB; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Hamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Tahirovic S; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany., Schwarzmaier SM; Institute for Stroke and Dementia Research (ISD), University Hospital, Ludwig-Maximilians-University Munich, Munich, Germany., Plesnila N; Institute for Stroke and Dementia Research (ISD), University Hospital, Ludwig-Maximilians-University Munich, Munich, Germany., Höglinger G; German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany; Department of Neurology, Ludwig-Maximilians-University Munich, Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany., Ondruschka B; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Institute of Legal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Bechmann I; Institute of Anatomy, University of Leipzig, Leipzig, Germany., Protzer U; Institute of Virology, Technical University of Munich/Helmholtz Munich, Munich, Germany; German Center for Infection Research (DZIF), Munich Partner Site, Munich, Germany., Elsner M; Institute for Tissue Engineering and Regenerative Medicine (iTERM), Helmholtz Munich, Neuherberg, Germany., Bhatia HS; Institute for Tissue Engineering and Regenerative Medicine (iTERM), Helmholtz Munich, Neuherberg, Germany; Institute for Stroke and Dementia Research (ISD), University Hospital, Ludwig-Maximilians-University Munich, Munich, Germany., Hellal F; Institute for Tissue Engineering and Regenerative Medicine (iTERM), Helmholtz Munich, Neuherberg, Germany; Institute for Stroke and Dementia Research (ISD), University Hospital, Ludwig-Maximilians-University Munich, Munich, Germany., Ertürk A; Institute for Tissue Engineering and Regenerative Medicine (iTERM), Helmholtz Munich, Neuherberg, Germany; Institute for Stroke and Dementia Research (ISD), University Hospital, Ludwig-Maximilians-University Munich, Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany; Koç University, School of Medicine, İstanbul, Turkey. Electronic address: ali.erturk@helmholtz-munich.de.

Publikováno v: Cell host & microbe [Cell Host Microbe] 2024 Nov 26. Date of Electronic Publication: 2024 Nov 26.

Balanced volatile sedation with isoflurane in critically ill patients with aneurysmal subarachnoid hemorrhage - a retrospective observational study.

Autor: Müller MB; Department of Anaesthesiology, University Hospital, LMU Munich, Munich, Germany., Terpolilli NA; Department of Neurosurgery, University Hospital, LMU Munich, Munich, Germany., Schwarzmaier SM; Department of Anaesthesiology, University Hospital, LMU Munich, Munich, Germany., Briegel J; Department of Anaesthesiology, University Hospital, LMU Munich, Munich, Germany., Huge V; Department of Anaesthesiology, University Hospital, LMU Munich, Munich, Germany.; Department of Critical Care and Anaesthesiology, Schön Klinik Bad Aibling, Bad Aibling, Germany.

Publikováno v: Frontiers in neurology [Front Neurol] 2023 Jun 22; Vol. 14, pp. 1164860. Date of Electronic Publication: 2023 Jun 22 (Print Publication: 2023).

Ca V 2.1 channel mutations causing familial hemiplegic migraine type 1 increase the susceptibility for cortical spreading depolarizations and seizures and worsen outcome after experimental traumatic brain injury.

Autor: Terpolilli NA; Institute for Stroke and Dementia Research, Munich University Hospital, Munich, Germany.; Department of Neurosurgery, Munich University Hospital, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany., Dolp R; Department of Neurosurgery, Munich University Hospital, Munich, Germany., Waehner K; Department of Neurosurgery, Mannheim University, Mannheim, Germany., Schwarzmaier SM; Institute for Stroke and Dementia Research, Munich University Hospital, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.; Department of Anesthesiology, Munich University Hospital, Mannheim, Germany., Rumbler E; Department of Neurosurgery, Munich University Hospital, Munich, Germany., Todorov B; Department of Human Genetics, Leiden University Medical Center, Leiden, Netherlands., Ferrari MD; Department of Neurology, Leiden University Medical Center, Leiden, Netherlands., van den Maagdenberg AMJM; Department of Human Genetics, Leiden University Medical Center, Leiden, Netherlands.; Department of Neurology, Leiden University Medical Center, Leiden, Netherlands., Plesnila N; Institute for Stroke and Dementia Research, Munich University Hospital, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.

Publikováno v: ELife [Elife] 2022 Mar 03; Vol. 11. Date of Electronic Publication: 2022 Mar 03.

Longitudinal Characterization of Blood-Brain Barrier Permeability after Experimental Traumatic Brain Injury by In Vivo 2-Photon Microscopy.

Autor: Hu Y; Institute for Stroke and Dementia Research (ISD) and Ludwig-Maximilians-University (LMU) Munich Medical Center, Munich, Germany.; First Teaching Hospital of the Tianjin University of Traditional Chinese Medicine, Tianjin, China.; Cluster for Systems Neurology (SyNergy), Munich, Germany., Seker B; Institute for Stroke and Dementia Research (ISD) and Ludwig-Maximilians-University (LMU) Munich Medical Center, Munich, Germany.; Cluster for Systems Neurology (SyNergy), Munich, Germany., Exner C; Institute for Stroke and Dementia Research (ISD) and Ludwig-Maximilians-University (LMU) Munich Medical Center, Munich, Germany.; Cluster for Systems Neurology (SyNergy), Munich, Germany., Zhang J; First Teaching Hospital of the Tianjin University of Traditional Chinese Medicine, Tianjin, China., Plesnila N; Institute for Stroke and Dementia Research (ISD) and Ludwig-Maximilians-University (LMU) Munich Medical Center, Munich, Germany.; Cluster for Systems Neurology (SyNergy), Munich, Germany., Schwarzmaier SM; Institute for Stroke and Dementia Research (ISD) and Ludwig-Maximilians-University (LMU) Munich Medical Center, Munich, Germany.; Department of Anesthesiology, Ludwig-Maximilians-University (LMU) Munich Medical Center, Munich, Germany.; Cluster for Systems Neurology (SyNergy), Munich, Germany.

Publikováno v: Journal of neurotrauma [J Neurotrauma] 2021 Feb 15; Vol. 38 (4), pp. 399-410. Date of Electronic Publication: 2020 Oct 30.

Plasminogen activator inhibitor-1 augments damage by impairing fibrinolysis after traumatic brain injury.

Autor: Griemert EV; Department of Anesthesiology, University Medical Center of Johannes-Gutenberg-University Mainz, Mainz, Germany., Schwarzmaier SM; Department of Anesthesiology, Ludwig-Maximilians-University (LMU) Munich Medical Center, Munich, Germany., Hummel R; Department of Anesthesiology, University Medical Center of Johannes-Gutenberg-University Mainz, Mainz, Germany., Gölz C; Department of Anesthesiology, University Medical Center of Johannes-Gutenberg-University Mainz, Mainz, Germany., Yang D; Department of Anesthesiology, University Medical Center of Johannes-Gutenberg-University Mainz, Mainz, Germany., Neuhaus W; Austrian Institute of Technology, Department Health and Environment, Molecular Diagnostics, Vienna, Austria., Burek M; Department of Anesthesia and Critical Care, University of Würzburg, Würzburg, Germany., Förster CY; Department of Anesthesia and Critical Care, University of Würzburg, Würzburg, Germany., Petkovic I; Department of Anesthesiology, University Medical Center of Johannes-Gutenberg-University Mainz, Mainz, Germany., Trabold R; Institute for Surgical Research at the Walter Brendel Center of Experimental Medicine, University of Munich Medical Center, Munich, Germany., Plesnila N; Institute for Stroke and Dementia Research (ISD), Ludwig-Maximilians-University (LMU) Munich Medical Center, Munich, Germany and Munich Cluster for Systems Neurology (Synergy), Munich, Germany., Engelhard K; Department of Anesthesiology, University Medical Center of Johannes-Gutenberg-University Mainz, Mainz, Germany., Schäfer MK; Department of Anesthesiology, University Medical Center of Johannes-Gutenberg-University Mainz, Mainz, Germany.; Focus Program Translational Neuroscience, University Medical Center of Johannes-Gutenberg-University Mainz, Mainz, Germany., Thal SC; Department of Anesthesiology, University Medical Center of Johannes-Gutenberg-University Mainz, Mainz, Germany.; Focus Program Translational Neuroscience, University Medical Center of Johannes-Gutenberg-University Mainz, Mainz, Germany.

Publikováno v: Annals of neurology [Ann Neurol] 2019 May; Vol. 85 (5), pp. 667-680. Date of Electronic Publication: 2019 Mar 30.