Microglia mediate neurocognitive deficits by eliminating C1q-tagged synapses in sepsis-associated encephalopathy.

Autor: Chung HY; Section of Translational Neuroimmunology, Department of Neurology, Jena University Hospital, Jena 07747, Germany.; Center for Sepsis Control and Care, Jena University Hospital, Jena 07747, Germany., Wickel J; Section of Translational Neuroimmunology, Department of Neurology, Jena University Hospital, Jena 07747, Germany.; Center for Sepsis Control and Care, Jena University Hospital, Jena 07747, Germany., Hahn N; Section of Translational Neuroimmunology, Department of Neurology, Jena University Hospital, Jena 07747, Germany.; Center for Sepsis Control and Care, Jena University Hospital, Jena 07747, Germany., Mein N; Section of Translational Neuroimmunology, Department of Neurology, Jena University Hospital, Jena 07747, Germany., Schwarzbrunn M; Section of Translational Neuroimmunology, Department of Neurology, Jena University Hospital, Jena 07747, Germany., Koch P; Leibniz Institute on Aging - Fritz Lipmann Institute (FLI), Jena 07745, Germany., Ceanga M; Section of Translational Neuroimmunology, Department of Neurology, Jena University Hospital, Jena 07747, Germany., Haselmann H; Section of Translational Neuroimmunology, Department of Neurology, Jena University Hospital, Jena 07747, Germany., Baade-Büttner C; Section of Translational Neuroimmunology, Department of Neurology, Jena University Hospital, Jena 07747, Germany., von Stackelberg N; Section of Translational Neuroimmunology, Department of Neurology, Jena University Hospital, Jena 07747, Germany., Hempel N; Section of Translational Neuroimmunology, Department of Neurology, Jena University Hospital, Jena 07747, Germany., Schmidl L; Section of Translational Neuroimmunology, Department of Neurology, Jena University Hospital, Jena 07747, Germany., Groth M; Leibniz Institute on Aging - Fritz Lipmann Institute (FLI), Jena 07745, Germany., Andreas N; Institute of Immunology, Jena University Hospital, Jena 07743, Germany., Götze J; Department of Anaesthesiology and Intensive Care Medicine, Jena University Hospital, Jena 07747, Germany.; Septomics Research Center, Jena University Hospital, Jena 07745, Germany., Coldewey SM; Center for Sepsis Control and Care, Jena University Hospital, Jena 07747, Germany.; Department of Anaesthesiology and Intensive Care Medicine, Jena University Hospital, Jena 07747, Germany.; Septomics Research Center, Jena University Hospital, Jena 07745, Germany., Bauer M; Center for Sepsis Control and Care, Jena University Hospital, Jena 07747, Germany.; Department of Anaesthesiology and Intensive Care Medicine, Jena University Hospital, Jena 07747, Germany., Mawrin C; Department of Neuropathology, University of Magdeburg, Magdeburg, Germany.; Section of Pathology, Institute of Forensic Medicine, Jena University Hospital, Jena 07749, Germany., Dargvainiene J; Neuroimmunology, Institute of Clinical Chemistry, UKSH, Kiel/Lübeck, Germany., Leypoldt F; Neuroimmunology, Institute of Clinical Chemistry, UKSH, Kiel/Lübeck, Germany.; Department of Neurology, Christian-Albrechts University, Kiel 24105, Germany., Steinke S; Department Medical Biotechnology, Institute of Biochemistry, Biotechnology and Bioinformatics, Technische Universität Braunschweig, Braunschweig, Germany., Wang ZQ; Leibniz Institute on Aging - Fritz Lipmann Institute (FLI), Jena 07745, Germany.; Faculty of Biological Sciences, Friedrich Schiller University, Jena 07745, Germany.; State Key Laboratory of Microbial Technology, Shandong University, Qingdao, China., Hust M; Department Medical Biotechnology, Institute of Biochemistry, Biotechnology and Bioinformatics, Technische Universität Braunschweig, Braunschweig, Germany., Geis C; Section of Translational Neuroimmunology, Department of Neurology, Jena University Hospital, Jena 07747, Germany.; Center for Sepsis Control and Care, Jena University Hospital, Jena 07747, Germany.

Publikováno v: Science advances [Sci Adv] 2023 May 26; Vol. 9 (21), pp. eabq7806. Date of Electronic Publication: 2023 May 26.

Extracellular vesicles in sepsis plasma mediate neuronal inflammation in the brain through miRNAs and innate immune signaling.

Autor: Park, Chanhee¹ (AUTHOR), Lei, Zhuofan¹ (AUTHOR), Li, Yun¹ (AUTHOR), Ren, Boyang¹ (AUTHOR), He, Junyun¹ (AUTHOR), Huang, Huang¹ (AUTHOR), Chen, Fengqian¹ (AUTHOR), Li, Hui¹ (AUTHOR), Brunner, Kavitha¹ (AUTHOR), Zhu, Jing¹ (AUTHOR), Jay, Steven M.² (AUTHOR), Williams, Brittney¹ (AUTHOR), Chao, Wei¹ (AUTHOR), Wu, Junfang^1,3 (AUTHOR) junfang.wu@som.umaryland.edu, Zou, Lin¹ (AUTHOR) lzou@som.umaryland.edu

Publikováno v: Journal of Neuroinflammation. 10/7/2024, Vol. 21 Issue 1, p1-18. 18p.

Low-dose PLX5622 treatment prevents neuroinflammatory and neurocognitive sequelae after sepsis.

Autor: Mein, Nils¹ (AUTHOR), von Stackelberg, Nikolai¹ (AUTHOR), Wickel, Jonathan^1,2 (AUTHOR), Geis, Christian^1,2,3 (AUTHOR), Chung, Ha-Yeun^1,2 (AUTHOR) Ha-Yeun.Chung@med.uni-jena.de

Publikováno v: Journal of Neuroinflammation. 12/1/2023, Vol. 20 Issue 1, p1-15. 15p.

Microglial Activation: Key Players in Sepsis-Associated Encephalopathy.

Autor: Hu, Jiyun^1,2,3 (AUTHOR) 218111146@csu.edu.cn, Xie, Shucai^1,2,3 (AUTHOR) xieshucai1990@foxmail.com, Zhang, Haisong^1,2,3 (AUTHOR) 218102101@csu.edu.cn, Wang, Xinrun^1,2,3 (AUTHOR) wangxr1893@163.com, Meng, Binbin^1,2,3 (AUTHOR) mbb18154698607@163.com, Zhang, Lina^1,2,3 (AUTHOR) zln7095@163.com

Publikováno v: Brain Sciences (2076-3425). Oct2023, Vol. 13 Issue 10, p1453. 15p.

Tackling Brain and Muscle Dysfunction in Acute Respiratory Distress Syndrome Survivors: NHLBI Workshop Report.

Autor: Palakshappa, Jessica A., Batt, Jane A. E., Bodine, Sue C., Connolly, Bronwen A., Doles, Jason, Falvey, Jason R., Ferrante, Lauren E., Files, D. Clark, Harhay, Michael O., Harrell, Kirsten, Hippensteel, Joseph A., Iwashyna, Theodore J., Jackson, James C., Lane-Fall, Meghan B., Monje, Michelle, Moss, Marc, Needham, Dale M., Semler, Matthew W., Lahiri, Shouri, Larsson, Lars

Publikováno v: American Journal of Respiratory & Critical Care Medicine; 6/1/2024, Vol. 209 Issue 11, p1304-1313, 10p