Large Language Models-Enabled Digital Twins for Precision Medicine in Rare Gynecological Tumors

Autor: Lammert, Jacqueline, Pfarr, Nicole, Kuligin, Leonid, Mathes, Sonja, Dreyer, Tobias, Modersohn, Luise, Metzger, Patrick, Ferber, Dyke, Kather, Jakob Nikolas, Truhn, Daniel, Adams, Lisa Christine, Bressem, Keno Kyrill, Lange, Sebastian, Schwamborn, Kristina, Boeker, Martin, Kiechle, Marion, Schatz, Ulrich A., Bronger, Holger, Tschochohei, Maximilian

Rare gynecological tumors (RGTs) present major clinical challenges due to their low incidence and heterogeneity. The lack of clear guidelines leads to suboptimal management and poor prognosis. Molecular tumor boards accelerate access to effective the

Externí odkaz: http://arxiv.org/abs/2409.00544

Modeling early phenotypes of Parkinson’s disease by age-induced midbrain-striatum assembloids

Autor: Kyriaki Barmpa, Claudia Saraiva, Diego Lopez-Pigozzi, Gemma Gomez-Giro, Elisa Gabassi, Sarah Spitz, Konstanze Brandauer, Juan E. Rodriguez Gatica, Paul Antony, Graham Robertson, Rahman Sabahi-Kaviani, Alessandro Bellapianta, Florentia Papastefanaki, Regina Luttge, Ulrich Kubitscheck, Ahmad Salti, Peter Ertl, Mario Bortolozzi, Rebecca Matsas, Frank Edenhofer, Jens C. Schwamborn

Publikováno v: Communications Biology, Vol 7, Iss 1, Pp 1-19 (2024)

Abstract Parkinson’s disease, an aging-associated neurodegenerative disorder, is characterised by nigrostriatal pathway dysfunction caused by the gradual loss of dopaminergic neurons in the substantia nigra pars compacta of the midbrain. Human in v

Externí odkaz: https://doaj.org/article/01a3e63dcff24b67a4571fd2ecb5411b

Declines in coastal macrozooplankton communities within a recent climate and ocean tipping point in the Tropical South Atlantic

Autor: Schwamborn, Denise Fabiana de Moraes Costa, Marcolin, Catarina da Rocha, Lins-Silva, Nathália, Brito-Lolaia, Morgana, Varona, Humberto L., Lira, Simone Maria de Albuquerque, Almeida, Alexandre Oliveira de, Schwamborn, Ralf

Publikováno v: In Science of the Total Environment 1 December 2024 954

Ice recrystallization inhibitors enable efficient cryopreservation of induced pluripotent stem cells: A functional and transcriptomic analysis

Autor: Kathleen Mommaerts, Satoshi Okawa, Margaux Schmitt, Olga Kofanova, Tracey R. Turner, Robert N. Ben, Antonio Del Sol, William Mathieson, Jens C. Schwamborn, Jason P. Acker, Fay Betsou

Publikováno v: Stem Cell Research, Vol 81, Iss , Pp 103583- (2024)

The successful use of human induced pluripotent stem cells (iPSCs) for research or clinical applications requires the development of robust, efficient, and reproducible cryopreservation protocols. After cryopreservation, the survival rate of iPSCs is

Externí odkaz: https://doaj.org/article/f9fa9b08064a4d7591c9bfe26303d593

Levodopa-induced dyskinesia in Parkinson's disease: Insights from cross-cohort prognostic analysis using machine learning

Autor: Acharya, Geeta, Aguayo, Gloria, Alexandre, Myriam, Ali, Muhammad, Ammerlann, Wim, Arena, Giuseppe, Bassis, Michele, Batutu, Roxane, Beaumont, Katy, Béchet, Sibylle, Berchem, Guy, Bisdorff, Alexandre, Boussaad, Ibrahim, Bouvier, David, Castillo, Lorieza, Contesotto, Gessica, DE Bremaeker, Nancy, Dewitt, Brian, Diederich, Nico, Dondelinger, Rene, Ramia, Nancy E., Ferrari, Angelo, Frauenknecht, Katrin, Fritz, Joëlle, Gamio, Carlos, Gantenbein, Manon, Gawron, Piotr, Georges, Laura, Ghosh, Soumyabrata, Giraitis, Marijus, Glaab, Enrico, Goergen, Martine, Gómez DE Lope, Elisa, Graas, Jérôme, Graziano, Mariella, Groues, Valentin, Grünewald, Anne, Hammot, Gaël, Anne-Marie, H.A.N.F.F., Hansen, Linda, Heneka, Michael, Henry, Estelle, Henry, Margaux, Herbrink, Sylvia, Herzinger, Sascha, Hundt, Alexander, Jacoby, Nadine, Jónsdóttir, Sonja, Klucken, Jochen, Kofanova, Olga, Krüger, Rejko, Lambert, Pauline, Landoulsi, Zied, Lentz, Roseline, Longhino, Laura, Lopes, Ana Festas, Lorentz, Victoria, Marques, Tainá M., Marques, Guilherme, Martins Conde, Patricia, Patrick, M.A.Y., Mcintyre, Deborah, Mediouni, Chouaib, Meisch, Francoise, Mendibide, Alexia, Menster, Myriam, Minelli, Maura, Mittelbronn, Michel, Mtimet, Saïda, Munsch, Maeva, Nati, Romain, Nehrbass, Ulf, Nickels, Sarah, Nicolai, Beatrice, Jean-Paul, N.I.C.O.L.A.Y., Noor, Fozia, Gomes, Clarissa P.C., Pachchek, Sinthuja, Pauly, Claire, Pauly, Laure, Pavelka, Lukas, Perquin, Magali, Pexaras, Achilleas, Rauschenberger, Armin, Rawal, Rajesh, Reddy Bobbili, Dheeraj, Remark, Lucie, Richard, Ilsé, Roland, Olivia, Roomp, Kirsten, Rosales, Eduardo, Sapienza, Stefano, Satagopam, Venkata, Schmitz, Sabine, Schneider, Reinhard, Schwamborn, Jens, Severino, Raquel, Sharify, Amir, Soare, Ruxandra, Soboleva, Ekaterina, Sokolowska, Kate, Theresine, Maud, Thien, Hermann, Thiry, Elodie, Ting Jiin Loo, Rebecca, Trouet, Johanna, Tsurkalenko, Olena, Vaillant, Michel, Vega, Carlos, Vilas Boas, Liliana, Wilmes, Paul, Wollscheid-Lengeling, Evi, Zelimkhanov, Gelani, Loo, Rebecca Ting Jiin, Mangone, Graziella, Khoury, Fouad, Vidailhet, Marie, Corvol, Jean-Christophe

Publikováno v: In Parkinsonism and Related Disorders September 2024 126