Synthesis of Indomorphan Pseudo Natural Product Inhibitors of Glucose Transporters GLUT‐1 and ‐3

Autor: Ceballos, J, Schwalfenberg, M, Karageorgis, G, Reckzeh, ES, Sievers, S, Ostermann, C, Pahl, A, Sellstedt, M, Nowacki, J, Carnero Corrales, MA, Wilke, J, Laraia, L, Tschapalda, K, Metz, M, Sehr, DA, Brand, S, Winklhofer, K, Janning, P, Ziegler, S, Waldmann, H

Bioactive compound design based on natural product (NP) structure may be limited due to partial coverage of NP‐like chemical space and biological target space. These limitations can be overcome by combining NP‐centered strategies with fragment‐

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https://eprints.whiterose.ac.uk/151777/1/anie.201909518.pdf

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Synthesis of Indomorphan Pseudo-Natural Product Inhibitors of Glucose Transporters GLUT-1 and -3.

Autor: Ceballos J; Department of Chemical Biology, Max-Planck-Institute of Molecular Physiology, Otto-Hahn-Strasse 11, 44227, Dortmund, Germany.; Current address: Laboratory of Catalysis and Organic Synthesis, EPFL SB ISIC LCSO, BCH 4221, 1015, Lausanne, Switzerland., Schwalfenberg M; Department of Chemical Biology, Max-Planck-Institute of Molecular Physiology, Otto-Hahn-Strasse 11, 44227, Dortmund, Germany., Karageorgis G; Department of Chemical Biology, Max-Planck-Institute of Molecular Physiology, Otto-Hahn-Strasse 11, 44227, Dortmund, Germany.; Current address: School of Chemistry, University of Leeds, Leeds, LS2 9JT, UK., Reckzeh ES; Department of Chemical Biology, Max-Planck-Institute of Molecular Physiology, Otto-Hahn-Strasse 11, 44227, Dortmund, Germany.; Faculty of Chemistry and Chemical Biology, Technical University Dortmund, Otto-Hahn-Strasse 6, 44227, Dortmund, Germany., Sievers S; Compound Management and Screening Center, Dortmund, Otto-Hahn-Strasse 11, 44227, Dortmund, Germany., Ostermann C; Compound Management and Screening Center, Dortmund, Otto-Hahn-Strasse 11, 44227, Dortmund, Germany., Pahl A; Compound Management and Screening Center, Dortmund, Otto-Hahn-Strasse 11, 44227, Dortmund, Germany., Sellstedt M; Department of Chemistry, Umeå University, 901 87, Umeå, Sweden.; Current address: Clinical Chemistry, Laboratory Medicine, University Hospital of Umeå, 901 85, Umeå, Sweden., Nowacki J; Department of Chemical Biology, Max-Planck-Institute of Molecular Physiology, Otto-Hahn-Strasse 11, 44227, Dortmund, Germany., Carnero Corrales MA; Department of Chemical Biology, Max-Planck-Institute of Molecular Physiology, Otto-Hahn-Strasse 11, 44227, Dortmund, Germany., Wilke J; Department of Chemical Biology, Max-Planck-Institute of Molecular Physiology, Otto-Hahn-Strasse 11, 44227, Dortmund, Germany.; Faculty of Chemistry and Chemical Biology, Technical University Dortmund, Otto-Hahn-Strasse 6, 44227, Dortmund, Germany., Laraia L; Department of Chemical Biology, Max-Planck-Institute of Molecular Physiology, Otto-Hahn-Strasse 11, 44227, Dortmund, Germany.; Current address: Department of Chemistry, Technical University of Denmark, Kemitorvet, Bygning 207, 2800, Kgs Lyngby, Denmark., Tschapalda K; Department of Chemical Biology, Max-Planck-Institute of Molecular Physiology, Otto-Hahn-Strasse 11, 44227, Dortmund, Germany., Metz M; Department of Chemical Biology, Max-Planck-Institute of Molecular Physiology, Otto-Hahn-Strasse 11, 44227, Dortmund, Germany., Sehr DA; Department of Molecular Cell Biology, Institute of Biochemistry and Pathobiochemistry, Ruhr University Bochum, 44801, Bochum, Germany., Brand S; Department of Chemical Biology, Max-Planck-Institute of Molecular Physiology, Otto-Hahn-Strasse 11, 44227, Dortmund, Germany., Winklhofer K; Department of Molecular Cell Biology, Institute of Biochemistry and Pathobiochemistry, Ruhr University Bochum, 44801, Bochum, Germany., Janning P; Department of Chemical Biology, Max-Planck-Institute of Molecular Physiology, Otto-Hahn-Strasse 11, 44227, Dortmund, Germany., Ziegler S; Department of Chemical Biology, Max-Planck-Institute of Molecular Physiology, Otto-Hahn-Strasse 11, 44227, Dortmund, Germany., Waldmann H; Department of Chemical Biology, Max-Planck-Institute of Molecular Physiology, Otto-Hahn-Strasse 11, 44227, Dortmund, Germany.; Faculty of Chemistry and Chemical Biology, Technical University Dortmund, Otto-Hahn-Strasse 6, 44227, Dortmund, Germany.

Publikováno v: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2019 Nov 18; Vol. 58 (47), pp. 17016-17025. Date of Electronic Publication: 2019 Oct 07.