Functional network alterations in young brain tumor patients with radiotherapy-induced memory impairments and vascular injury

Autor: Melanie A. Morrison, Sadie Walter, Sabine Mueller, Erin Felton, Angela Jakary, Schuyler Stoller, Annette M. Molinaro, Steve E. Braunstein, Christopher P. Hess, Janine M. Lupo

Publikováno v: Frontiers in Neurology, Vol 13 (2022)

BackgroundCognitive impairment and cerebral microbleeds (CMBs) are long-term side-effects of cranial radiation therapy (RT). Previously we showed that memory function is disrupted in young patients and that the rate of cognitive decline correlates wi

Externí odkaz: https://doaj.org/article/ab370c76d94a43578fb7338965adc997

4329 Investigating the role of Klotho in neurocognitive outcomes, brain volumes, and white matter changes in pediatric brain tumor survivors

Autor: Caleb Simpeh Edwards, Schuyler Stoller, Sol Savchuk, Christian Rodrigo Ugaz Valencia, Liz Tong, Andreas Rauschecker, Dena Dubal, Cassie Kline, Sabine Mueller

Publikováno v: Journal of Clinical and Translational Science, Vol 4, Pp 98-98 (2020)

OBJECTIVES/GOALS: Klotho is a protein linked to improved cognition in aging adults. A specific KLOTHO gene variant, KL-VS, increases circulating levels of Klotho. The current study aims to identify if the KL-VS haplotype and Klotho levels are associa

Externí odkaz: https://doaj.org/article/92f26ecb54fe4390ab175e4abf82c891

Pediatric pineoblastoma: A pooled outcome study of North American and Australian therapeutic data

Autor: Jordan R Hansford, Jie Huang, Raelene Endersby, Andrew J Dodgshun, Bryan K Li, Eugene Hwang, Sarah Leary, Amar Gajjar, Katja Von Hoff, Olivia Wells, Alison Wray, Rishi S Kotecha, David R Raleigh, Schuyler Stoller, Sabine Mueller, Steven E Schild, Pratiti Bandopadhayay, Maryam Fouladi, Eric Bouffet, Annie Huang, Arzu Onar-Thomas, Nicholas G Gottardo

Publikováno v: Neuro-oncology advances, vol 4, iss 1
Hansford, J R, Huang, J, Endersby, R, Dodgshun, A J, Li, B K, Hwang, E, Leary, S, Gajjar, A, Von Hoff, K, Wells, O, Wray, A, Kotecha, R S, Raleigh, D R, Stoller, S, Mueller, S, Schild, S E, Bandopadhayay, P, Fouladi, M, Bouffet, E, Huang, A, Onar-Thomas, A & Gottardo, N G 2022, ' Pediatric pineoblastoma : A pooled outcome study of North American and Australian therapeutic data ', Neuro-oncology advances, vol. 4, no. 1, pp. vdac056 . https://doi.org/10.1093/noajnl/vdac056

Background Pineoblastoma is a rare brain tumor usually diagnosed in children. Given its rarity, no pineoblastoma-specific trials have been conducted. Studies have included pineoblastoma accruing for other embryonal tumors over the past 30 years. Thes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9320949348d570c6ed28db14a66fc2d
https://pubmed.ncbi.nlm.nih.gov/35664557

Relationship between 7T MR-angiography features of vascular injury and cognitive decline in young brain tumor patients treated with radiation therapy

Autor: Melanie A. Morrison, Erin Felton, Steve Braunstein, Christopher P. Hess, Sivakami Avadiappan, Annette M. Molinaro, Janine M. Lupo, Sabine Mueller, Schuyler Stoller, Angela Jakary

Publikováno v: J Neurooncol

PURPOSE: Although radiation therapy (RT) is a common treatment for pediatric brain tumors, it is associated with detrimental long-term effects such as impaired cognition, vascular injury, and increased stroke risk. This study aimed to develop metrics

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d2c8cbbc4b0cfb54b81d857b8676112
https://pubmed.ncbi.nlm.nih.gov/33893923

Rate of radiation-induced microbleed formation on 7T MRI relates to cognitive impairment in young patients treated with radiation therapy for a brain tumor

Autor: Sivakami Avadiappan, Janine M. Lupo, Anu Banerjee, Sabine Mueller, Schuyler Stoller, Annette M. Molinaro, Melanie A. Morrison, Erin Felton, Christopher P. Hess, Justin Yuan, Steve Braunstein, Angela Jakary

Publikováno v: Radiother Oncol

BackgroundRadiation therapy (RT) is essential to the management of many brain tumors, but has been known to lead to cognitive decline and vascular injury in the form of cerebral microbleeds (CMBs).PurposeIn a subset of children, adolescents, and youn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45b4d6c58943d6cdac9d1a0251295662
https://pubmed.ncbi.nlm.nih.gov/32966846