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Multi-level functional genomics reveals molecular and cellular oncogenicity of patient-based 3' untranslated region mutations.

Autor: Schuster SL; Molecular and Cellular Biology Graduate Program, University of Washington, Seattle, WA 98195, USA; Human Biology Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA., Arora S; Human Biology Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA., Wladyka CL; Human Biology Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA., Itagi P; Human Biology Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA., Corey L; Human Biology Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA., Young D; Human Biology Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA., Stackhouse BL; Human Biology Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA., Kollath L; Department of Urology, University of Washington, Seattle, WA 98195, USA., Wu QV; Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA., Corey E; Department of Urology, University of Washington, Seattle, WA 98195, USA., True LD; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA 98195, USA., Ha G; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA; Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA., Paddison PJ; Molecular and Cellular Biology Graduate Program, University of Washington, Seattle, WA 98195, USA; Human Biology Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA., Hsieh AC; Molecular and Cellular Biology Graduate Program, University of Washington, Seattle, WA 98195, USA; Human Biology Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA; Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA; Department of Medicine, University of Washington, Seattle, WA 98195, USA. Electronic address: ahsieh@fredhutch.org.

Publikováno v: Cell reports [Cell Rep] 2023 Aug 29; Vol. 42 (8), pp. 112840. Date of Electronic Publication: 2023 Jul 28.

An intestinal organoid-based platform that recreates susceptibility to T-cell-mediated tissue injury.

Autor: Matsuzawa-Ishimoto Y; Kimmel Center for Biology and Medicine at the Skirball Institute.; Department of Microbiology, and., Hine A; Department of Microbiology, and.; Division of Gastroenterology and Hepatology, Department of Medicine, New York University Grossman School of Medicine, New York, NY., Shono Y; Department of Immunology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY., Rudensky E; Kimmel Center for Biology and Medicine at the Skirball Institute.; Sackler Institute of Graduate Biomedical Sciences., Lazrak A; Department of Immunology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY., Yeung F; Kimmel Center for Biology and Medicine at the Skirball Institute.; Sackler Institute of Graduate Biomedical Sciences., Neil JA; Kimmel Center for Biology and Medicine at the Skirball Institute.; Department of Microbiology, and., Yao X; Kimmel Center for Biology and Medicine at the Skirball Institute.; Department of Microbiology, and., Chen YH; Kimmel Center for Biology and Medicine at the Skirball Institute.; Department of Microbiology, and., Heaney T; Kimmel Center for Biology and Medicine at the Skirball Institute., Schuster SL; Kimmel Center for Biology and Medicine at the Skirball Institute., Zwack EE; Department of Microbiology, and., Axelrad JE; Division of Gastroenterology and Hepatology, Department of Medicine, New York University Grossman School of Medicine, New York, NY., Hudesman D; Division of Gastroenterology and Hepatology, Department of Medicine, New York University Grossman School of Medicine, New York, NY., Tsai JJ; Department of Immunology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY., Nichols K; Department of Immunology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY., Dewan MZ; Histopathology Core, Office of Collaborative Science, and., Cammer M; Microscopy Core, Office of Collaborative Science, New York University Grossman School of Medicine, New York, NY., Beal A; Innate Immunity Research Unit, GlaxoSmithKline, Collegeville, PA., Hoffman S; Innate Immunity Research Unit, GlaxoSmithKline, Collegeville, PA., Geddes B; Innate Immunity Research Unit, GlaxoSmithKline, Collegeville, PA., Bertin J; Innate Immunity Research Unit, GlaxoSmithKline, Collegeville, PA., Liu C; Department of Pathology and Laboratory Medicine, Rutgers New Jersey Medical School and Rutgers Robert Wood Johnson Medical School, Newark, NJ., Torres VJ; Department of Microbiology, and., Loke P; Department of Microbiology, and., van den Brink MRM; Department of Immunology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY.; Weil Medical College of Cornell University, New York, NY; and.; Adult BMT Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY., Cadwell K; Kimmel Center for Biology and Medicine at the Skirball Institute.; Department of Microbiology, and.; Division of Gastroenterology and Hepatology, Department of Medicine, New York University Grossman School of Medicine, New York, NY.

Publikováno v: Blood [Blood] 2020 Jun 25; Vol. 135 (26), pp. 2388-2401.

The Untranslated Regions of mRNAs in Cancer.

Autor: Schuster SL; Molecular and Cellular Biology, University of Washington, Seattle, WA 98195, USA; Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA., Hsieh AC; Molecular and Cellular Biology, University of Washington, Seattle, WA 98195, USA; Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA; School of Medicine and Genome Sciences, University of Washington, Seattle, WA 98195, USA. Electronic address: ahsieh@fredhutch.org.

Publikováno v: Trends in cancer [Trends Cancer] 2019 Apr; Vol. 5 (4), pp. 245-262. Date of Electronic Publication: 2019 Mar 22.

Contractility as a global regulator of cellular morphology, velocity, and directionality in low-adhesive fibrillary micro-environments.

Autor: Schuster SL; Department of Pharmacy, Pharmaceutical Biology, Ludwig-Maximilians-Universität, Butenandtstraße 5-13, D-81377 Munich, Germany., Segerer FJ; Faculty of Physics and Center for NanoScience, Ludwig-Maximilians-Universität, Geschwister-Scholl-Platz 1, D-80539 Munich, Germany., Gegenfurtner FA; Department of Pharmacy, Pharmaceutical Biology, Ludwig-Maximilians-Universität, Butenandtstraße 5-13, D-81377 Munich, Germany., Kick K; Department of Pharmacy, Pharmaceutical Biology, Ludwig-Maximilians-Universität, Butenandtstraße 5-13, D-81377 Munich, Germany., Schreiber C; Faculty of Physics and Center for NanoScience, Ludwig-Maximilians-Universität, Geschwister-Scholl-Platz 1, D-80539 Munich, Germany., Albert M; Faculty of Physics and Center for NanoScience, Ludwig-Maximilians-Universität, Geschwister-Scholl-Platz 1, D-80539 Munich, Germany., Vollmar AM; Department of Pharmacy, Pharmaceutical Biology, Ludwig-Maximilians-Universität, Butenandtstraße 5-13, D-81377 Munich, Germany., Rädler JO; Faculty of Physics and Center for NanoScience, Ludwig-Maximilians-Universität, Geschwister-Scholl-Platz 1, D-80539 Munich, Germany., Zahler S; Department of Pharmacy, Pharmaceutical Biology, Ludwig-Maximilians-Universität, Butenandtstraße 5-13, D-81377 Munich, Germany. Electronic address: stefan.zahler@cup.uni-muenchen.de.

Publikováno v: Biomaterials [Biomaterials] 2016 Sep; Vol. 102, pp. 137-47. Date of Electronic Publication: 2016 Jun 14.