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SUMO pathway inhibition targets an aggressive pancreatic cancer subtype

Autor: Biedersta¨dt, Alexander, Hassan, Zonera, Schneeweis, Christian, Schick, Markus, Schneider, Lara, Muckenhuber, Alexander, Hong, Yingfen, Siegers, Gerrit, Nilsson, Lisa, Wirth, Matthias, Dantes, Zahra, Steiger, Katja, Schunck, Kathrin, Langston, Steve, Lenhof, H-P, Coluccio, Andrea, Orben, Felix, Slawska, Jolanta, Scherger, Anna, Saur, Dieter, Mu¨ller, Stefan, Rad, Roland, Weichert, Wilko, Nilsson, Jonas, Reichert, Maximilian, Schneider, Gu¨nter, Keller, Ulrich

Publikováno v: Gut; 2020, Vol. 69 Issue: 8 p1472-1482, 11p

Characterization of nucleolar SUMO isopeptidases unveils a general p53-independent checkpoint of impaired ribosome biogenesis.

Autor: Dönig J; Institute of Biochemistry II, Goethe University Frankfurt, Medical Faculty, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany., Mende H; Institute of Biochemistry II, Goethe University Frankfurt, Medical Faculty, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany., Davila Gallesio J; Department of Molecular Biology, University Medical Centre Göttingen, Humboldtallee 23, 37073, Göttingen, Germany., Wagner K; Institute of Biochemistry II, Goethe University Frankfurt, Medical Faculty, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany., Hotz P; Institute of Biochemistry II, Goethe University Frankfurt, Medical Faculty, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany., Schunck K; Institute of Biochemistry II, Goethe University Frankfurt, Medical Faculty, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany.; PharmBioTec gGmbH, Schiffweiler, Germany., Piller T; Institute of Biochemistry II, Goethe University Frankfurt, Medical Faculty, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany.; Sanofi AG, Frankfurt, Germany., Hölper S; Institute of Biochemistry II, Goethe University Frankfurt, Medical Faculty, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany.; Sanofi AG, Frankfurt, Germany., Uhan S; Department of Hematology, Oncology and Cancer Immunology (Campus Benjamin Franklin), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Hindenburgdamm 30, 12203, Berlin, Germany.; German Cancer Consortium (DKTK), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.; Max Delbrück Center, Robert-Rössle-Str. 10, 13125, Berlin, Germany., Kaulich M; Institute of Biochemistry II, Goethe University Frankfurt, Medical Faculty, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany., Wirth M; Department of Hematology, Oncology and Cancer Immunology (Campus Benjamin Franklin), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Hindenburgdamm 30, 12203, Berlin, Germany.; German Cancer Consortium (DKTK), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.; Max Delbrück Center, Robert-Rössle-Str. 10, 13125, Berlin, Germany.; Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Robert-Koch-Str. 40, 37075, Göttingen, Germany., Keller U; Department of Hematology, Oncology and Cancer Immunology (Campus Benjamin Franklin), Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Hindenburgdamm 30, 12203, Berlin, Germany.; German Cancer Consortium (DKTK), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.; Max Delbrück Center, Robert-Rössle-Str. 10, 13125, Berlin, Germany., Tascher G; Institute of Biochemistry II, Goethe University Frankfurt, Medical Faculty, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany., Bohnsack KE; Department of Molecular Biology, University Medical Centre Göttingen, Humboldtallee 23, 37073, Göttingen, Germany., Müller S; Institute of Biochemistry II, Goethe University Frankfurt, Medical Faculty, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany. ste.mueller@em.uni-frankfurt.de.; German Cancer Consortium (DKTK), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany. ste.mueller@em.uni-frankfurt.de.

Publikováno v: Nature communications [Nat Commun] 2023 Dec 08; Vol. 14 (1), pp. 8121. Date of Electronic Publication: 2023 Dec 08.