Detection and Analysis of Novel Microproteins in the Human Heart based on Protein Evidence, Conservation, Subcellular Localization, and Interacting Proteins

Autor: Schulz, Jana Felicitas

Kürzlich wurde mithilfe von Ribo-seq Experimenten die Translation hunderter Mikroproteine in menschlichen Herzen entdeckt. Diese blieben zuvor aufgrund ihrer geringen Größe (< 100 Aminosäuren) unentdeckt, und ihre physiologische Rolle ist noch we

Externí odkaz: http://edoc.hu-berlin.de/18452/26845

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Additional file 1 of A trans locus causes a ribosomopathy in hypertrophic hearts that affects mRNA translation in a protein length-dependent fashion

Autor: Witte, Franziska, Ruiz-Orera, Jorge, Mattioli, Camilla Ciolli, Blachut, Susanne, Adami, Eleonora, Schulz, Jana Felicitas, Schneider-Lunitz, Valentin, Hummel, Oliver, Patone, Giannino, Mücke, Michael Benedikt, Šilhavý, Jan, Heinig, Matthias, Bottolo, Leonardo, Sanchis, Daniel, Vingron, Martin, Chekulaeva, Marina, Pravenec, Michal, Hubner, Norbert, van Heesch, Sebastiaan

Additional file 1: Figure S1-S6, related to Figs. 1, 2, 3, 4 - Document with supplemental Figures 1, 2, 3, 4, 5, 6, including figure captions.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5c202fd363001db4c32ae95d5215ad4

A trans locus causes a ribosomopathy in hypertrophic hearts that affects mRNA translation in a protein length-dependent fashion

Autor: Witte, Franziska, Ruiz-Orera, Jorge, Mattioli, Camilla Ciolli, Blachut, Susanne, Adami, Eleonora, Schulz, Jana Felicitas, Schneider-Lunitz, Valentin, Hummel, Oliver, Patone, Giannino, Mücke, Michael Benedikt, Šilhavý, Jan, Heinig, Matthias, Bottolo, Leonardo, Sanchis, Daniel, Vingron, Martin, Chekulaeva, Marina, Pravenec, Michal, Hubner, Norbert, van Heesch, Sebastiaan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::34cdf6a59dc687e522a1ad7d48469a66
https://mediatum.ub.tum.de/1651737

A trans locus causes a ribosomopathy in hypertrophic hearts that affects mRNA translation in a protein length-dependent fashion.

Autor: Witte F; Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125, Berlin, Germany.; Present Address: NUVISAN ICB GmbH, Lead Discovery-Structrual Biology, 13353, Berlin, Germany., Ruiz-Orera J; Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125, Berlin, Germany., Mattioli CC; Berlin Institute for Medical Systems Biology (BIMSB), Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 10115, Berlin, Germany.; Present Address: Department of Biological Regulation, Weizmann Institute of Science, 7610001, Rehovot, Israel., Blachut S; Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125, Berlin, Germany., Adami E; Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125, Berlin, Germany.; Present Address: Program in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore, Singapore, 169857, Singapore., Schulz JF; Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125, Berlin, Germany., Schneider-Lunitz V; Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125, Berlin, Germany., Hummel O; Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125, Berlin, Germany., Patone G; Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125, Berlin, Germany., Mücke MB; Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125, Berlin, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, 13347, Berlin, Germany.; Charité-Universitätsmedizin, 10117, Berlin, Germany., Šilhavý J; Institute of Physiology of the Czech Academy of Sciences, 4, 142 20, Praha, Czech Republic., Heinig M; Institute of Computational Biology (ICB), HMGU, Ingolstaedter Landstr. 1, 85764 Neuherberg, Munich, Germany.; Department of Informatics, Technische Universitaet Muenchen (TUM), Boltzmannstr. 3, 85748 Garching, Munich, Germany., Bottolo L; Department of Medical Genetics, University of Cambridge, Cambridge, CB2 0QQ, UK.; The Alan Turing Institute, London, NW1 2DB, UK.; MRC Biostatistics Unit, University of Cambridge, Cambridge, CB2 0SR, UK., Sanchis D; Institut de Recerca Biomedica de Lleida (IRBLLEIDA), Universitat de Lleida, Edifici Biomedicina-I. Av. Rovira Roure, 80, 25198, Lleida, Spain., Vingron M; Department of Computational Molecular Biology, Max Planck Institute for Molecular Genetics, 14195, Berlin, Germany., Chekulaeva M; Berlin Institute for Medical Systems Biology (BIMSB), Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 10115, Berlin, Germany., Pravenec M; Institute of Physiology of the Czech Academy of Sciences, 4, 142 20, Praha, Czech Republic., Hubner N; Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125, Berlin, Germany. nhuebner@mdc-berlin.de.; DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, 13347, Berlin, Germany. nhuebner@mdc-berlin.de.; Charité-Universitätsmedizin, 10117, Berlin, Germany. nhuebner@mdc-berlin.de., van Heesch S; Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), 13125, Berlin, Germany. s.vanheesch@prinsesmaximacentrum.nl.; Present Address: The Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands. s.vanheesch@prinsesmaximacentrum.nl.

Publikováno v: Genome biology [Genome Biol] 2021 Jun 28; Vol. 22 (1), pp. 191. Date of Electronic Publication: 2021 Jun 28.