Mutation-specific CAR T cells as precision therapy for IGLV3-21 ^R110 expressing high-risk chronic lymphocytic leukemia.

Autor: Märkl F; Division of Clinical Pharmacology, Klinikum der Universität München, Munich, Germany., Schultheiß C; Division of Medical Oncology, University Hospital Basel, Basel, Switzerland.; Laboratory of Translational Immuno-Oncology, Department of Biomedicine, University and University Hospital Basel, Basel, Switzerland., Ali M; Internal Medicine IV, Oncology/Hematology, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany., Chen SS; Karches Center for Oncology Research, The Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USA., Zintchenko M; Faculty of Biology, University of Freiburg, Freiburg, Germany., Egli L; Cellular Immunotherapy, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland., Mietz J; Cellular Immunotherapy, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland., Chijioke O; Cellular Immunotherapy, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland.; Institute of Pathology and Medical Genetics, University Hospital Basel, Basel, Switzerland., Paschold L; Internal Medicine IV, Oncology/Hematology, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany., Spajic S; Division of Clinical Pharmacology, Klinikum der Universität München, Munich, Germany., Holtermann A; Division of Clinical Pharmacology, Klinikum der Universität München, Munich, Germany., Dörr J; Division of Clinical Pharmacology, Klinikum der Universität München, Munich, Germany., Stock S; Division of Clinical Pharmacology, Klinikum der Universität München, Munich, Germany., Zingg A; Division of Medical Oncology, University Hospital Basel, Basel, Switzerland.; Laboratory of Cancer Immunotherapy, Department of Biomedicine, University and University Hospital Basel, Basel, Switzerland., Läubli H; Division of Medical Oncology, University Hospital Basel, Basel, Switzerland.; Laboratory of Cancer Immunotherapy, Department of Biomedicine, University and University Hospital Basel, Basel, Switzerland., Piseddu I; Division of Clinical Pharmacology, Klinikum der Universität München, Munich, Germany., Anz D; Division of Clinical Pharmacology, Klinikum der Universität München, Munich, Germany., Minden MD; AVA-lifescience GmbH, Ferdinand-Porsche-Straße 5/1, Denzlingen, Germany., Zhang T; Internal Medicine IV, Oncology/Hematology, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany., Nerreter T; Medizinische Klinik und Poliklinik II, Universitätsklinikum Würzburg, Würzburg, Germany., Hudecek M; Medizinische Klinik und Poliklinik II, Universitätsklinikum Würzburg, Würzburg, Germany., Minguet S; Faculty of Biology, University of Freiburg, Freiburg, Germany.; Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany.; Center of Chronic Immunodeficiency CCI, University Clinics and Medical Faculty, Freiburg, Germany., Chiorazzi N; Karches Center for Oncology Research, The Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USA., Kobold S; Division of Clinical Pharmacology, Klinikum der Universität München, Munich, Germany. sebastian.kobold@med.uni-muenchen.de.; German Cancer Consortium (DKTK), Partner Site Munich, Munich, Germany. sebastian.kobold@med.uni-muenchen.de.; Einheit für Klinische Pharmakologie (EKLiP), Helmholtz Munich, Research Center for Environmental Health (HMGU), Neuherberg, Germany. sebastian.kobold@med.uni-muenchen.de., Binder M; Division of Medical Oncology, University Hospital Basel, Basel, Switzerland. Mascha.Binder@unibas.ch.; Laboratory of Translational Immuno-Oncology, Department of Biomedicine, University and University Hospital Basel, Basel, Switzerland. Mascha.Binder@unibas.ch.

Publikováno v: Nature communications [Nat Commun] 2024 Feb 02; Vol. 15 (1), pp. 993. Date of Electronic Publication: 2024 Feb 02.

A20 haploinsufficiency disturbs immune homeostasis and drives the transformation of lymphocytes with permissive antigen receptors.

Autor: Schultheiß C; Division of Medical Oncology, University Hospital Basel, Basel, Switzerland.; Laboratory of Translational Immuno-Oncology, Department of Biomedicine, University and University Hospital Basel, Basel, Switzerland., Paschold L; Internal Medicine IV, Oncology/Hematology, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany., Mohebiany AN; Institute for Molecular Medicine, University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany.; Microglia and Inflammation in Neurological Disorders (MIND) Lab, VIB Center for Molecular Neurology, VIB, Antwerp, Belgium.; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium., Escher M; Internal Medicine IV, Oncology/Hematology, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany., Kattimani YM; Institute for Molecular Medicine, University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany., Müller M; Institute for Molecular Medicine, University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany., Schmidt-Barbo P; Division of Medical Oncology, University Hospital Basel, Basel, Switzerland.; Laboratory of Translational Immuno-Oncology, Department of Biomedicine, University and University Hospital Basel, Basel, Switzerland.; Collaborative Research Institute Intelligent Oncology (CRIION), Freiburg, Germany., Mensa-Vilaró A; Department of Immunology, Hospital Clínic de Barcelona, Barcelona, Spain.; Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain., Aróstegui JI; Department of Immunology, Hospital Clínic de Barcelona, Barcelona, Spain.; Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain.; School of Medicine, University of Barcelona, Barcelona, Spain., Boursier G; Department of molecular and cytogenomics, Rare and Autoinflammatory Diseases Laboratory, CHU Montpellier, IRMB, University of Montpellier, INSERM, CEREMAIA, Montpellier, France., de Moreuil C; Department of Internal Medicine, CHU Brest, Université de Bretagne Occidentale, Brest, France., Hautala T; Research Unit of Biomedicine, University of Oulu and Department of Internal Medicine, Oulu University Hospital, Oulu, Finland., Willscher E; Internal Medicine IV, Oncology/Hematology, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany., Jonas H; Internal Medicine IV, Oncology/Hematology, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany., Chinchuluun N; Internal Medicine IV, Oncology/Hematology, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany., Grosser B; Institute for Pathology, University Medical Center Augsburg, Augsburg, Germany., Märkl B; Institute for Pathology, University Medical Center Augsburg, Augsburg, Germany., Klapper W; Institute of Pathology, Hematopathology Section, and Lymph Node Registry, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany., Oommen PT; Department of Pediatric Oncology, Hematology, and Clinical Immunology, Medical Faculty, Center for Child and Adolescent Health, Heinrich Heine University Düsseldorf, Düsseldorf, Germany., Gössling K; Department of Pediatric Oncology, Hematology, and Clinical Immunology, Medical Faculty, Center for Child and Adolescent Health, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.; Department of Pediatrics, University Hospital Schleswig-Holstein, Kiel, Germany., Hoffmann K; Institute for Human Genetics and Molecular Biology, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany., Tiegs G; Institute for Experimental Immunology and Hepatology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Czernilofsky F; Department of Medicine V, Hematology, Oncology, and Rheumatology, University of Heidelberg, Heidelberg, Germany.; European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.; Molecular Medicine Partnership Unit (MMPU), Heidelberg, Germany., Dietrich S; Department of Medicine V, Hematology, Oncology, and Rheumatology, University of Heidelberg, Heidelberg, Germany.; European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.; Molecular Medicine Partnership Unit (MMPU), Heidelberg, Germany.; Department of Translational Medical Oncology, National Center for Tumor Diseases (NCT) Heidelberg and German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Hematolgy, Oncology, and Immunolgy, University Hospital of Düsseldorf, Düsseldorf, Germany., Freeman A; Laboratory of Clinical Immunology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA., Schwartz DM; Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, USA., Waisman A; Institute for Molecular Medicine, University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany., Aksentijevich I; Inflammatory Disease Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Binder M; Division of Medical Oncology, University Hospital Basel, Basel, Switzerland.; Laboratory of Translational Immuno-Oncology, Department of Biomedicine, University and University Hospital Basel, Basel, Switzerland.; Collaborative Research Institute Intelligent Oncology (CRIION), Freiburg, Germany.

Publikováno v: Science advances [Sci Adv] 2024 Aug 23; Vol. 10 (34), pp. eadl3975. Date of Electronic Publication: 2024 Aug 21.

Trifluridine/Tipiracil Based Chemoradiation in locally Advanced Rectal Cancer: The Phase I/II TARC Trial.

Autor: Thiele B; Medical Oncology, University Hospital Basel, Basel, Switzerland; Laboratory of Translational Immuno-Oncology, Department of Biomedicine, University and University Hospital Basel, Basel, Switzerland., Stein A; Hematology-Oncology Practice Eppendorf (HOPE), Hamburg, Germany; University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany. Electronic address: stein@hope-hamburg.de., Schultheiß C; Medical Oncology, University Hospital Basel, Basel, Switzerland; Laboratory of Translational Immuno-Oncology, Department of Biomedicine, University and University Hospital Basel, Basel, Switzerland., Paschold L; Internal Medicine IV - Oncology/Hematology, University Hospital, Martin-Luther University, Halle, Germany., Jonas H; Internal Medicine IV - Oncology/Hematology, University Hospital, Martin-Luther University, Halle, Germany., Goekkurt E; Hematology-Oncology Practice Eppendorf (HOPE), Hamburg, Germany; University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Rüssel J; Internal Medicine IV - Oncology/Hematology, University Hospital, Martin-Luther University, Halle, Germany., Schuch G; Hämatologisch- Onkologische Praxis Altona, Hamburg, Germany., Wierecky J; Überörtliche Gemeinschaftspraxis für Innere Medizin Schwerpunkt Hämatologie, Onkologie und Palliativmedizin, Hamburg, Germany., Sinn M; University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Tintelnot J; University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Petersen C; University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Department of Radiotherapy and Radiooncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Rothkamm K; University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Department of Radiotherapy and Radiooncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Vettorazzi E; Institute of Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Binder M; Medical Oncology, University Hospital Basel, Basel, Switzerland; Laboratory of Translational Immuno-Oncology, Department of Biomedicine, University and University Hospital Basel, Basel, Switzerland. Electronic address: mascha.binder@unibas.ch.

Publikováno v: Clinical colorectal cancer [Clin Colorectal Cancer] 2024 Jun 22. Date of Electronic Publication: 2024 Jun 22.

NKp44/HLA-DP-dependent regulation of CD8 effector T cells by NK cells.

Autor: Padoan B; Research Department Virus Immunology, Leibniz Institute of Virology, 20251 Hamburg, Germany., Casar C; Bioinformatics Core, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany., Krause J; I. Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany; Center for Immunology, University of Minnesota, Minneapolis, MN, USA., Schultheiss C; Division of Medical Oncology, University Hospital Basel, 4031 Basel, Switzerland; Laboratory of Translational Immuno-Oncology, Department of Biomedicine, University and University Hospital Basel, 4031 Basel, Switzerland., Baumdick ME; Research Department Virus Immunology, Leibniz Institute of Virology, 20251 Hamburg, Germany; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany., Niehrs A; Research Department Virus Immunology, Leibniz Institute of Virology, 20251 Hamburg, Germany., Zecher BF; Research Department Virus Immunology, Leibniz Institute of Virology, 20251 Hamburg, Germany; I. Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany., Pujantell M; Research Department Virus Immunology, Leibniz Institute of Virology, 20251 Hamburg, Germany., Yuki Y; Basic Science Program, Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA; Laboratory of Integrative Cancer Immunology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA., Martin M; Basic Science Program, Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA; Laboratory of Integrative Cancer Immunology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA., Remmerswaal EBM; Department of Experimental Immunology, Amsterdam Infection and Immunity Institute, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands., Dekker T; Department of Experimental Immunology, Amsterdam Infection and Immunity Institute, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands., van der Bom-Baylon ND; Department of Experimental Immunology, Amsterdam Infection and Immunity Institute, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands., Noble JA; Department of Pediatrics UCSF, Children's Hospital Oakland Research Institute, Oakland, CA 94609, USA., Carrington M; Basic Science Program, Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA; Laboratory of Integrative Cancer Immunology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA., Bemelman FJ; Renal Transplant Unit, Division of Internal Medicine, Academic Medical Centre, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands., van Lier RAW; University Medical Center Utrecht, Utrecht, the Netherlands., Binder M; Division of Medical Oncology, University Hospital Basel, 4031 Basel, Switzerland; Laboratory of Translational Immuno-Oncology, Department of Biomedicine, University and University Hospital Basel, 4031 Basel, Switzerland., Gagliani N; I. Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany; Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany; Hamburg Center for Translational Immunology (HCTI), Hamburg, Germany., Bunders MJ; Research Department Virus Immunology, Leibniz Institute of Virology, 20251 Hamburg, Germany; III. Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany; Hamburg Center for Translational Immunology (HCTI), Hamburg, Germany., Altfeld M; Research Department Virus Immunology, Leibniz Institute of Virology, 20251 Hamburg, Germany; Hamburg Center for Translational Immunology (HCTI), Hamburg, Germany. Electronic address: marcus.altfeld@leibniz-liv.de.

Publikováno v: Cell reports [Cell Rep] 2024 Apr 23; Vol. 43 (4), pp. 114089. Date of Electronic Publication: 2024 Apr 13.

Ancestor regression in linear structural equation models.

Autor: Schultheiss, C, Bühlmann, P

Publikováno v: Biometrika; Dec2023, Vol. 110 Issue 4, p1117-1124, 8p