Zobrazeno 1 - 10
of 15 497
pro vyhledávání: '"Schulman P"'
We consider the dynamics imposed by natural selection on the populations of two competing, sexually reproducing, haploid species. In this setting, the fitness of any genome varies over time due to the changing population mix of the competing species;
Externí odkaz:
http://arxiv.org/abs/2406.03938
Autor:
Durante, Zane, Sarkar, Bidipta, Gong, Ran, Taori, Rohan, Noda, Yusuke, Tang, Paul, Adeli, Ehsan, Lakshmikanth, Shrinidhi Kowshika, Schulman, Kevin, Milstein, Arnold, Terzopoulos, Demetri, Famoti, Ade, Kuno, Noboru, Llorens, Ashley, Vo, Hoi, Ikeuchi, Katsu, Fei-Fei, Li, Gao, Jianfeng, Wake, Naoki, Huang, Qiuyuan
The development of artificial intelligence systems is transitioning from creating static, task-specific models to dynamic, agent-based systems capable of performing well in a wide range of applications. We propose an Interactive Agent Foundation Mode
Externí odkaz:
http://arxiv.org/abs/2402.05929
An acyclic causal structure can be described with directed acyclic graph (DAG), where arrows indicate the possibility of direct causation. The task of learning this structure from data is known as "causal discovery." Diverse populations or changing e
Externí odkaz:
http://arxiv.org/abs/2311.07454
Product of experts (PoE) are layered networks in which the value at each node is an AND (or product) of the values (possibly negated) at its inputs. These were introduced as a neural network architecture that can efficiently learn to generate high-di
Externí odkaz:
http://arxiv.org/abs/2310.09397
Autor:
Haghofer, Andreas, Parlak, Eda, Bartel, Alexander, Donovan, Taryn A., Assenmacher, Charles-Antoine, Bolfa, Pompei, Dark, Michael J., Fuchs-Baumgartinger, Andrea, Klang, Andrea, Jäger, Kathrin, Klopfleisch, Robert, Merz, Sophie, Richter, Barbara, Schulman, F. Yvonne, Janout, Hannah, Ganz, Jonathan, Scharinger, Josef, Aubreville, Marc, Winkler, Stephan M., Kiupel, Matti, Bertram, Christof A.
Variation in nuclear size and shape is an important criterion of malignancy for many tumor types; however, categorical estimates by pathologists have poor reproducibility. Measurements of nuclear characteristics (morphometry) can improve reproducibil
Externí odkaz:
http://arxiv.org/abs/2309.15031
We consider the problem of identifying, from statistics, a distribution of discrete random variables $X_1,\ldots,X_n$ that is a mixture of $k$ product distributions. The best previous sample complexity for $n \in O(k)$ was $(1/\zeta)^{O(k^2 \log k)}$
Externí odkaz:
http://arxiv.org/abs/2309.13993
Publikováno v:
Hereditas, Vol 161, Iss 1, Pp 1-8 (2024)
Abstract Background Plant mutagenesis creates novel alleles, thereby increasing genetic and phenotypic diversity. The availability of the faba bean (Vicia faba L.) reference genome and a growing set of additional genomic resources has increased the s
Externí odkaz:
https://doaj.org/article/8c46d6d569f846979eddc247b3644e97
Autor:
Daniel C. Scott, Suresh Dharuman, Elizabeth Griffith, Sergio C. Chai, Jarrid Ronnebaum, Moeko T. King, Rajendra Tangallapally, Chan Lee, Clifford T. Gee, Lei Yang, Yong Li, Victoria C. Loudon, Ha Won Lee, Jason Ochoada, Darcie J. Miller, Thilina Jayasinghe, Joao A. Paulo, Stephen J. Elledge, J. Wade Harper, Taosheng Chen, Richard E. Lee, Brenda A. Schulman
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract PROTAC® (proteolysis-targeting chimera) molecules induce proximity between an E3 ligase and protein-of-interest (POI) to target the POI for ubiquitin-mediated degradation. Cooperative E3-PROTAC-POI complexes have potential to achieve neo-su
Externí odkaz:
https://doaj.org/article/6c50c513c918469eaf4c94f0f0e0d58b
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Molecular biosensors that accurately measure protein concentrations without external equipment are critical for solving numerous problems in diagnostics and therapeutics. Modularly transducing the binding of protein antibodies, protein switc
Externí odkaz:
https://doaj.org/article/a4d9604f50f246d4a1188d8f1ec761f6
Autor:
Ruohong Shi, Kuan-Lin Chen, Joshua Fern, Siming Deng, Yixin Liu, Dominic Scalise, Qi Huang, Noah J. Cowan, David H. Gracias, Rebecca Schulman
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract The ability to transform matter between numerous physical states or shapes without wires or external devices is a major challenge for robotics and materials design. Organisms can transform their shapes using biomolecules carrying specific in
Externí odkaz:
https://doaj.org/article/e701545ec5ed49b1805c7ba4f5f40361