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IMI2-PainCare-BioPain-RCT2 protocol: a randomized, double-blind, placebo-controlled, crossover, multicenter trial in healthy subjects to investigate the effects of lacosamide, pregabalin, and tapentadol on biomarkers of pain processing observed by non-invasive neurophysiological measurements of human spinal cord and brainstem activity.

Autor: Leone C; Department of Human Neuroscience, Sapienza University, Rome, Italy. caterinamaria.leone@gmail.com., Di Stefano G; Department of Human Neuroscience, Sapienza University, Rome, Italy., Di Pietro G; Department of Human Neuroscience, Sapienza University, Rome, Italy., Bloms-Funke P; Translational Science & Intelligence, Grünenthal GmbH, Aachen, Germany., Boesl I; Clinical Science Development, Grünenthal GmbH, Aachen, Germany., Caspani O; Department of Neurophysiology, Mannheim Center for Translational Neurosciences (MCTN), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany., Chapman SC; Neuroscience Next Generation Therapeutics, Eli Lilly and Company, Lilly Innovation Center, Cambridge, MA, USA.; Eli Lilly and Company, Arlington Square, Bracknell, UK., Finnerup NB; Danish Pain Research Center, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Garcia-Larrea L; Lyon Neurosciences Center Research Unit Inserm U 1028, Pierre Wertheimer Hospital, Hospices Civils de Lyon, Lyon 1 University, Lyon, France., Li T; Teva Pharmaceutical Industries Ltd., Petah Tikva, Israel., Goetz M; MRC Systems GmbH, Heidelberg, Germany., Mouraux A; Institute of Neuroscience (IoNS), UCLouvain, Brussels, Belgium., Pelz B; MRC Systems GmbH, Heidelberg, Germany., Pogatzki-Zahn E; Department of Anaesthesiology, Intensive Care and Pain Medicine, University Hospital Münster, Münster, Germany., Schilder A; Department of Neurophysiology, Mannheim Center for Translational Neurosciences (MCTN), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany., Schnetter E; University Computing Centre, University of Heidelberg, Heidelberg, Germany., Schubart K; ConsulTech GmbH, Berlin, Germany., Tracey I; Wellcome Centre for Integrative Neuroimaging, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK., Troconiz IF; Department of Pharmaceutical Technology and Chemistry, School of Pharmacy and Nutrition, University of Navarra, Pamplona, Spain., Van Niel H; Mature Products Development, Grünenthal GmbH, Aachen, Germany., Hernandez JMV; Welab Barcelona, Barcelona, Spain.; Drug Discovery & Preclinical Development, ESTEVE Pharmaceuticals, Barcelona, Spain., Vincent K; Nuffield Department of Women's and Reproductive Health (NDWRH), University of Oxford, Oxford, UK., Vollert J; Department of Neurophysiology, Mannheim Center for Translational Neurosciences (MCTN), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.; Department of Anaesthesiology, Intensive Care and Pain Medicine, University Hospital Münster, Münster, Germany.; Pain Research, Department of Surgery and Cancer, Imperial College London, London, UK., Wanigasekera V; Wellcome Centre for Integrative Neuroimaging, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK., Wittayer M; Department of Neurophysiology, Mannheim Center for Translational Neurosciences (MCTN), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany., Phillips KG; Neuroscience Next Generation Therapeutics, Eli Lilly and Company, Lilly Innovation Center, Cambridge, MA, USA.; Eli Lilly and Company, Arlington Square, Bracknell, UK., Truini A; Department of Human Neuroscience, Sapienza University, Rome, Italy., Treede RD; Department of Neurophysiology, Mannheim Center for Translational Neurosciences (MCTN), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.

Publikováno v: Trials [Trials] 2022 Sep 05; Vol. 23 (1), pp. 739. Date of Electronic Publication: 2022 Sep 05.

Benefits of a Pediatric Clinic Simulation Using Standardized Patients in Family Nurse Practitioner Education.

Autor: Weston C; About the Authors Cindy Weston, DNP, APRN, FNP-BC, is associate professor and associate dean for clinical and outreach affairs, Texas A&M University College of Nursing, Bryan, Texas. Kara Jones-Schubart, DNP, APRN, FNP-BC, is clinical assistant professor, University of Florida College of Nursing, Gainesville, Florida. Martha Hare, DNP, APRN, FNP-BC, is clinical assistant professor, Texas A&M University College of Nursing. Kevin Gosselin, PhD, is director, Academics and Biostatistics, HonorHealth Research Institute, Scottsdale, Arizona. Sharon Cook, BSN, RN, is an orthopedics/trauma team nurse, Medical City, Plano, Texas. The authors acknowledge the contribution of Dr. Gang Han for statistical review. This work was supported by Texas A&M University College of Nursing Seed Grant Program (Dr. Cindy Weston, PI). For more information, contact Dr. Weston at cweston@tamu.edu., Jones-Schubart K, Hare M, Gosselin K, Cook S

Publikováno v: Nursing education perspectives [Nurs Educ Perspect] 2021 Nov-Dec 01; Vol. 42 (6), pp. E31-E33.

Oct1 regulates trophoblast development during early mouse embryogenesis.

Autor: Sebastiano V; Max Planck Institute for Molecular Biomedicine, Department of Cell and Developmental Biology, Röntgenstrasse, 20 48149 Münster, Germany., Dalvai M, Gentile L, Schubart K, Sutter J, Wu GM, Tapia N, Esch D, Ju JY, Hübner K, Bravo MJ, Schöler HR, Cavaleri F, Matthias P

Publikováno v: Development (Cambridge, England) [Development] 2010 Nov; Vol. 137 (21), pp. 3551-60. Date of Electronic Publication: 2010 Sep 28.