Zobrazeno 1 - 10 of 24 pro vyhledávání: '"Schroeder GK"'
1
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
2
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
3
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
4
Akademický článek
Discovery of MK-1454: A Potent Cyclic Dinucleotide Stimulator of Interferon Genes Agonist for the Treatment of Cancer.
Autor: Chang W; Merck & Co., Inc., Kenilworth, New Jersey 07033, United States., Altman MD; Merck & Co., Inc., Boston, Massachusetts 02115, United States., Lesburg CA; Merck & Co., Inc., Boston, Massachusetts 02115, United States., Perera SA; Merck & Co., Inc., Boston, Massachusetts 02115, United States., Piesvaux JA; Merck & Co., Inc., Boston, Massachusetts 02115, United States., Schroeder GK; Merck & Co., Inc., Boston, Massachusetts 02115, United States., Wyss DF; Merck & Co., Inc., Kenilworth, New Jersey 07033, United States., Cemerski S; Merck & Co., Inc., Boston, Massachusetts 02115, United States., Chen Y; Merck & Co., Inc., Boston, Massachusetts 02115, United States., DiNunzio E; Merck & Co., Inc., Kenilworth, New Jersey 07033, United States., Haidle AM; Merck & Co., Inc., Boston, Massachusetts 02115, United States., Ho T; Merck & Co., Inc., West Point, Pennsylvania 19486, United States., Kariv I; Merck & Co., Inc., Boston, Massachusetts 02115, United States., Knemeyer I; Merck & Co., Inc., Boston, Massachusetts 02115, United States., Kopinja JE; Merck & Co., Inc., Boston, Massachusetts 02115, United States., Lacey BM; Merck & Co., Inc., Boston, Massachusetts 02115, United States., Laskey J; Merck & Co., Inc., Boston, Massachusetts 02115, United States., Lim J; Merck & Co., Inc., Boston, Massachusetts 02115, United States., Long BJ; Merck & Co., Inc., Boston, Massachusetts 02115, United States., Ma Y; Merck & Co., Inc., Boston, Massachusetts 02115, United States., Maddess ML; Merck & Co., Inc., Boston, Massachusetts 02115, United States., Pan BS; Merck & Co., Inc., Boston, Massachusetts 02115, United States., Presland JP; Merck & Co., Inc., Boston, Massachusetts 02115, United States., Spooner E; Merck & Co., Inc., Boston, Massachusetts 02115, United States., Steinhuebel D; Merck & Co., Inc., Boston, Massachusetts 02115, United States., Truong Q; Merck & Co., Inc., Kenilworth, New Jersey 07033, United States., Zhang Z; Pharmaron Beijing Co. Ltd., Beijing 100176, P. R. China., Fu J; Pharmaron Beijing Co. Ltd., Beijing 100176, P. R. China., Addona GH; Merck & Co., Inc., Boston, Massachusetts 02115, United States., Northrup AB; Merck & Co., Inc., Boston, Massachusetts 02115, United States., Parmee E; Merck & Co., Inc., Kenilworth, New Jersey 07033, United States., Tata JR; Merck & Co., Inc., Kenilworth, New Jersey 07033, United States., Bennett DJ; Merck & Co., Inc., Boston, Massachusetts 02115, United States., Cumming JN; Merck & Co., Inc., Boston, Massachusetts 02115, United States., Siu T; Merck & Co., Inc., Boston, Massachusetts 02115, United States., Trotter BW; Merck & Co., Inc., Boston, Massachusetts 02115, United States.
Publikováno v: Journal of medicinal chemistry [J Med Chem] 2022 Apr 14; Vol. 65 (7), pp. 5675-5689. Date of Electronic Publication: 2022 Mar 25.
Zobrazit plný text záznamu
5
Akademický článek
An orally available non-nucleotide STING agonist with antitumor activity.
Autor: Pan BS; Department of Quantitative Biosciences, Merck & Co., Inc., Kenilworth, NJ, USA., Perera SA; Department of Quantitative Biosciences, Merck & Co., Inc., Kenilworth, NJ, USA. samanthi_perera@merck.com gottfried.schroeder@merck.com wes.trotter@kronosbio.com jonathan.bennett@merck.com george_addona@merck.com., Piesvaux JA; Department of Quantitative Biosciences, Merck & Co., Inc., Kenilworth, NJ, USA., Presland JP; Department of Quantitative Biosciences, Merck & Co., Inc., Kenilworth, NJ, USA., Schroeder GK; Department of Quantitative Biosciences, Merck & Co., Inc., Kenilworth, NJ, USA. samanthi_perera@merck.com gottfried.schroeder@merck.com wes.trotter@kronosbio.com jonathan.bennett@merck.com george_addona@merck.com., Cumming JN; Department of Discovery Chemistry, Merck & Co., Inc., Kenilworth, NJ, USA., Trotter BW; Department of Discovery Chemistry, Merck & Co., Inc., Kenilworth, NJ, USA. samanthi_perera@merck.com gottfried.schroeder@merck.com wes.trotter@kronosbio.com jonathan.bennett@merck.com george_addona@merck.com., Altman MD; Department of Discovery Chemistry, Merck & Co., Inc., Kenilworth, NJ, USA., Buevich AV; Department of Discovery Chemistry, Merck & Co., Inc., Kenilworth, NJ, USA., Cash B; Department of Discovery Chemistry, Merck & Co., Inc., Kenilworth, NJ, USA., Cemerski S; Department of Discovery Oncology, Merck & Co., Inc., Kenilworth, NJ, USA., Chang W; Department of Discovery Chemistry, Merck & Co., Inc., Kenilworth, NJ, USA., Chen Y; Department of Quantitative Biosciences, Merck & Co., Inc., Kenilworth, NJ, USA., Dandliker PJ; Department of Quantitative Biosciences, Merck & Co., Inc., Kenilworth, NJ, USA., Feng G; Department of Quantitative Biosciences, Merck & Co., Inc., Kenilworth, NJ, USA., Haidle A; Department of Discovery Chemistry, Merck & Co., Inc., Kenilworth, NJ, USA., Henderson T; Department of Discovery Chemistry, Merck & Co., Inc., Kenilworth, NJ, USA., Jewell J; Department of Discovery Chemistry, Merck & Co., Inc., Kenilworth, NJ, USA., Kariv I; Department of Quantitative Biosciences, Merck & Co., Inc., Kenilworth, NJ, USA., Knemeyer I; Department of Pharmacokinetics, Merck & Co., Inc., Kenilworth, NJ, USA., Kopinja J; Department of Quantitative Biosciences, Merck & Co., Inc., Kenilworth, NJ, USA., Lacey BM; Department of Quantitative Biosciences, Merck & Co., Inc., Kenilworth, NJ, USA., Laskey J; Department of Quantitative Biosciences, Merck & Co., Inc., Kenilworth, NJ, USA., Lesburg CA; Department of Discovery Chemistry, Merck & Co., Inc., Kenilworth, NJ, USA., Liang R; Department of Discovery Chemistry, Merck & Co., Inc., Kenilworth, NJ, USA., Long BJ; Department of Quantitative Biosciences, Merck & Co., Inc., Kenilworth, NJ, USA., Lu M; Department of Discovery Chemistry, Merck & Co., Inc., Kenilworth, NJ, USA., Ma Y; Department of Quantitative Biosciences, Merck & Co., Inc., Kenilworth, NJ, USA., Minnihan EC; Department of Discovery Pharmaceutical Sciences, Merck & Co., Inc., Kenilworth, NJ, USA., O'Donnell G; Department of Quantitative Biosciences, Merck & Co., Inc., Kenilworth, NJ, USA., Otte R; Department of Discovery Chemistry, Merck & Co., Inc., Kenilworth, NJ, USA., Price L; Department of Quantitative Biosciences, Merck & Co., Inc., Kenilworth, NJ, USA., Rakhilina L; Department of Quantitative Biosciences, Merck & Co., Inc., Kenilworth, NJ, USA., Sauvagnat B; Department of Quantitative Biosciences, Merck & Co., Inc., Kenilworth, NJ, USA., Sharma S; Department of Discovery Oncology, Merck & Co., Inc., Kenilworth, NJ, USA., Tyagarajan S; Department of Discovery Chemistry, Merck & Co., Inc., Kenilworth, NJ, USA., Woo H; Department of Pharmacokinetics, Merck & Co., Inc., Kenilworth, NJ, USA., Wyss DF; Department of Discovery Chemistry, Merck & Co., Inc., Kenilworth, NJ, USA., Xu S; Department of Quantitative Biosciences, Merck & Co., Inc., Kenilworth, NJ, USA., Bennett DJ; Department of Discovery Chemistry, Merck & Co., Inc., Kenilworth, NJ, USA. samanthi_perera@merck.com gottfried.schroeder@merck.com wes.trotter@kronosbio.com jonathan.bennett@merck.com george_addona@merck.com., Addona GH; Department of Quantitative Biosciences, Merck & Co., Inc., Kenilworth, NJ, USA. samanthi_perera@merck.com gottfried.schroeder@merck.com wes.trotter@kronosbio.com jonathan.bennett@merck.com george_addona@merck.com.
Publikováno v: Science (New York, N.Y.) [Science] 2020 Aug 21; Vol. 369 (6506).
Zobrazit plný text záznamu
6
Akademický článek
Discovery of a Novel cGAMP Competitive Ligand of the Inactive Form of STING.
Autor: Siu T; Departments of Chemistry, Immunology, Chemistry Modeling and Informatics, In Vitro Pharmacology, Target Protein Design and Structural Chemistry, Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Altman MD; Departments of Chemistry, Immunology, Chemistry Modeling and Informatics, In Vitro Pharmacology, Target Protein Design and Structural Chemistry, Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Baltus GA; Departments of Chemistry, Immunology, Chemistry Modeling and Informatics, In Vitro Pharmacology, Target Protein Design and Structural Chemistry, Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Childers M; Departments of Chemistry, Immunology, Chemistry Modeling and Informatics, In Vitro Pharmacology, Target Protein Design and Structural Chemistry, Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Ellis JM; Departments of Chemistry, Immunology, Chemistry Modeling and Informatics, In Vitro Pharmacology, Target Protein Design and Structural Chemistry, Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Gunaydin H; Departments of Chemistry, Immunology, Chemistry Modeling and Informatics, In Vitro Pharmacology, Target Protein Design and Structural Chemistry, Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Hatch H; Departments of Chemistry, Immunology, Chemistry Modeling and Informatics, In Vitro Pharmacology, Target Protein Design and Structural Chemistry, Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Ho T; Departments of Chemistry, Immunology, Chemistry Modeling and Informatics, In Vitro Pharmacology, Target Protein Design and Structural Chemistry, Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Jewell J; Departments of Chemistry, Immunology, Chemistry Modeling and Informatics, In Vitro Pharmacology, Target Protein Design and Structural Chemistry, Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Lacey BM; Departments of Chemistry, Immunology, Chemistry Modeling and Informatics, In Vitro Pharmacology, Target Protein Design and Structural Chemistry, Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Lesburg CA; Departments of Chemistry, Immunology, Chemistry Modeling and Informatics, In Vitro Pharmacology, Target Protein Design and Structural Chemistry, Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Pan BS; Departments of Chemistry, Immunology, Chemistry Modeling and Informatics, In Vitro Pharmacology, Target Protein Design and Structural Chemistry, Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Sauvagnat B; Departments of Chemistry, Immunology, Chemistry Modeling and Informatics, In Vitro Pharmacology, Target Protein Design and Structural Chemistry, Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Schroeder GK; Departments of Chemistry, Immunology, Chemistry Modeling and Informatics, In Vitro Pharmacology, Target Protein Design and Structural Chemistry, Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States., Xu S; Departments of Chemistry, Immunology, Chemistry Modeling and Informatics, In Vitro Pharmacology, Target Protein Design and Structural Chemistry, Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States.
Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2018 Dec 06; Vol. 10 (1), pp. 92-97. Date of Electronic Publication: 2018 Dec 06 (Print Publication: 2019).
Zobrazit plný text záznamu
7
Akademický článek
Dissecting Therapeutic Resistance to ERK Inhibition.
Autor: Jha S; Early Development and Discovery Sciences, Merck Research Laboratories, Boston, Massachusetts., Morris EJ; Early Development and Discovery Sciences, Merck Research Laboratories, Boston, Massachusetts., Hruza A; Early Development and Discovery Sciences, Merck Research Laboratories, Kenilworth, New Jersey., Mansueto MS; Early Development and Discovery Sciences, Merck Research Laboratories, Boston, Massachusetts., Schroeder GK; Early Development and Discovery Sciences, Merck Research Laboratories, Boston, Massachusetts., Arbanas J; Early Development and Discovery Sciences, Merck Research Laboratories, Boston, Massachusetts., McMasters D; Early Development and Discovery Sciences, Merck Research Laboratories, Boston, Massachusetts., Restaino CR; Early Development and Discovery Sciences, Merck Research Laboratories, Boston, Massachusetts., Dayananth P; Early Development and Discovery Sciences, Merck Research Laboratories, Kenilworth, New Jersey., Black S; Early Development and Discovery Sciences, Merck Research Laboratories, Kenilworth, New Jersey., Elsen NL; Early Development and Discovery Sciences, Merck Research Laboratories, Kenilworth, New Jersey., Mannarino A; Early Development and Discovery Sciences, Merck Research Laboratories, Boston, Massachusetts., Cooper A; Early Development and Discovery Sciences, Merck Research Laboratories, Kenilworth, New Jersey., Fawell S; Early Development and Discovery Sciences, Merck Research Laboratories, Boston, Massachusetts., Zawel L; Early Development and Discovery Sciences, Merck Research Laboratories, Boston, Massachusetts., Jayaraman L; Early Development and Discovery Sciences, Merck Research Laboratories, Boston, Massachusetts. ahmed.samatar@therametbio.com ljayaraman@ceruleanrx.com., Samatar AA; Early Development and Discovery Sciences, Merck Research Laboratories, Boston, Massachusetts. ahmed.samatar@therametbio.com ljayaraman@ceruleanrx.com.
Publikováno v: Molecular cancer therapeutics [Mol Cancer Ther] 2016 Apr; Vol. 15 (4), pp. 548-59. Date of Electronic Publication: 2016 Feb 01.
Zobrazit plný text záznamu
8
Akademický článek
Reactions of Cg10062, a cis-3-Chloroacrylic Acid Dehalogenase Homologue, with Acetylene and Allene Substrates: Evidence for a Hydration-Dependent Decarboxylation.
Autor: Huddleston JP; Division of Medicinal Chemistry, College of Pharmacy, University of Texas, Austin, Texas 78712, United States., Johnson WH Jr; Division of Medicinal Chemistry, College of Pharmacy, University of Texas, Austin, Texas 78712, United States., Schroeder GK; Division of Medicinal Chemistry, College of Pharmacy, University of Texas, Austin, Texas 78712, United States., Whitman CP; Division of Medicinal Chemistry, College of Pharmacy, University of Texas, Austin, Texas 78712, United States.
Publikováno v: Biochemistry [Biochemistry] 2015 May 19; Vol. 54 (19), pp. 3009-23. Date of Electronic Publication: 2015 May 01.
Zobrazit plný text záznamu
9
Akademický článek
A mutational analysis of the active site loop residues in cis-3-Chloroacrylic acid dehalogenase.
Autor: Schroeder GK; Division of Medicinal Chemistry, College of Pharmacy, University of Texas at Austin, Austin, Texas 78712, USA., Huddleston JP, Johnson WH Jr, Whitman CP
Publikováno v: Biochemistry [Biochemistry] 2013 Jun 18; Vol. 52 (24), pp. 4204-16. Date of Electronic Publication: 2013 Jun 05.
Zobrazit plný text záznamu
10
Akademický článek
A pre-steady state kinetic analysis of the αY60W mutant of trans-3-chloroacrylic acid dehalogenase: implications for the mechanism of the wild-type enzyme.
Autor: Huddleston JP; Division of Medicinal Chemistry, College of Pharmacy, The University of Texas at Austin, Austin, Texas 78712, United States., Schroeder GK, Johnson KA, Whitman CP
Publikováno v: Biochemistry [Biochemistry] 2012 Nov 20; Vol. 51 (46), pp. 9420-35. Date of Electronic Publication: 2012 Nov 08.
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje