Genetic insights into resting heart rate and its role in cardiovascular disease.

Autor: van de Vegte YJ; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, 9700RB, the Netherlands., Eppinga RN; Department of Cardiology, Isala Zwolle ziekenhuis, Zwolle, 8025 AB, the Netherlands., van der Ende MY; Department of Cardiology, University medical Center Utrecht, Utrecht, 3584 Cx, the Netherlands., Hagemeijer YP; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, 9700RB, the Netherlands.; Analytical Biochemistry, University of Groningen, Groningen, 9713 AV, the Netherlands., Mahendran Y; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medicine Science, University of Copenhagen, Copenhagen Ø, 2100, Denmark., Salfati E; Department of Medicine, Stanford University School of Medicine, Stanford, 94305, USA.; Faculty of Medicine, University of Iceland, Reykjavik, 101, Iceland., Smith AV; Department of Biostatistics, University of Michigan, Ann Arbor, MI48109, USA., Tan VY; Bristol Medical School, Population Health Sciences, University of Bristol, Bristol, BS82BN, UK.; MRC Integrative Epidemiology, University of Bristol, Bristol, BS82BN, UK., Arking DE; McKusick-Nathans Institute, Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, 21215, USA., Ntalla I; Clinical Pharmacology and Precision Medicine, William Harvey Research Institute, Barts and The London Faculty of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK., Appel EV; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medicine Science, University of Copenhagen, Copenhagen Ø, 2100, Denmark., Schurmann C; The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, 10029, USA., Brody JA; Medicine, University of Washington, Seattle, 98195, USA., Rueedi R; Department of Computational Biology, University of Lausanne, Lausanne, 1015, Switzerland.; Swiss Institute of Bioinformatics, Lausanne, 1015, Switzerland., Polasek O; Department of Public Health, University of Split School of Medicine, Split, 21000, Croatia.; Algebra LAB, Algebra University College, Zagreb, 10000, Croatia., Sveinbjornsson G; deCODE genetics / Amgen Inc., Reykjavik, 102, Iceland., Lecoeur C; UMR 8199, University of Lille Nord de France, Lille, 59000, France., Ladenvall C; Clinial Genomics Uppsala, Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, 75185, Sweden.; Lund University Diabetes Center, Department of Clinical Sciences, Lund University, Malmö, 20502, Sweden., Zhao JH; BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, Victor Phillip Dahdaleh Heart & Lung Research Institute, University of Cambridge, Cambridge, CB2 0BB, UK., Isaacs A; CARIM School for Cardiovascular Diseases, Maastricht Centre for Systems Biology (MaCSBio), Department of Physiology, Maastricht University, Maastricht, 6229ER, Netherlands., Wang L; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, 63108-2212, Campus Box 8506, USA., Luan J; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK., Hwang SJ; Division of Intramural Research, National Heart Lung and Blood Institute, NIH, USA, Framingham, 1702, USA., Mononen N; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, FI-33014, Finland.; Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, FI-33014, Finland., Auro K; Department of Health, unit of genetics and biomarkers, , National Institute for Health and Welfare, Finland, Helsinki, FI-00290, Finland.; Department of molecular medicine, University of Helsinki, Helsinki, FI-00290, Finland., Jackson AU; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, 48109, USA., Bielak LF; Department of Epidemiology, University of Michigan, Ann Arbor, MI, 48109, USA., Zeng L; Department of Cardiology, Deutsches Herzzentrum München, Technische Universität München, Munich, 80636, Germany., Shah N; Division of Population Health and Genomics, School of Medicine, University of Dundee, Dundee, DD1 9SY, UK.; Pharmacogenetics Research Lab, Department of Pharmacy, COMSATS University Islamabad, Abbottabad, 22060, Pakistan., Nethander M; Sahlgrenska Osteoporosis Centre, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, 41345, Sweden.; Bioinformatics Core Facility, Sahlgrenska Academy, University of Gothenburg, Gothenburg, 40530, Sweden., Campbell A; Centre for Genomic and Experimental Medicine, Institute of Genetics & Cancer, University of Edinburgh, Edinburgh, EH4 2XU, UK.; Usher Institute for Population Health Sciences and Informatics, The University of Edinburgh, Edinburgh, EH16 4UX, UK., Rankinen T; Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, 70808, USA., Pechlivanis S; Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, University Duisburg-Essen, Essen, 45122, Germany., Qi L; Department of Epidemiology, Tulane University, New Orleans, LA, 70112, USA., Zhao W; Department of Epidemiology, University of Michigan, Ann Arbor, MI, 48109, USA.; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, 48104, USA., Rizzi F; Unit of Biomedicine, Bio4Dreams-Business Nursery for Life Sciences, Milano, 20121, Italy., Tanaka T; Longitudinal Study Section, National Institute on Aging, Baltimore, 21224, USA., Robino A; Institute for Maternal and Child Health - IRCCS 'Burlo Garofolo', Trieste, 34137, Italy., Cocca M; Institute for Maternal and Child Health - IRCCS 'Burlo Garofolo', Trieste, 34137, Italy., Lange L; Medicine, University of Colorado Anschutz Medical Campus, Aurora, 80045, USA., Müller-Nurasyid M; IBE, Ludwig-Maximilians-University Munich, LMU Munich, Munich, 81377, Germany.; Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center, Johannes Gutenberg University, Mainz, 55101, Germany.; Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, 85764, Germany., Roselli C; Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, 85764, Germany.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, 02142, USA., Zhang W; Department of Epidemiology and Biostatistics, Imperial College London, London, W2 1PG, UK.; Department of Cardiology, Ealing Hospital, London North West University Healthcare NHS Trust, Middlesex, UB1 3HW, UK., Kleber ME; Vth Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, University of Heidelberg, Mannheim, 68167, Germany.; SYNLAB MVZ Humangenetik Mannheim, Mannheim, 68163, Germany., Guo X; Pediatrics, The Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA, Torrance, 90502, USA.; Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, 90502, USA., Lin HJ; Pediatrics, The Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA, Torrance, 90502, USA.; Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, 90502, USA., Pavani F; Institute for Biomedicine, Eurac Research, Bolzano, 39100, Italy., Galesloot TE; Radboud university medical center, Nijmegen, 6500 HB, the Netherlands., Noordam R; Department of Internal Medicine, section Gerontology and Geriatrics, Leiden University Medical Center, Leiden, 2300 RC, the Netherlands., Milaneschi Y; Department of Psychiatry, Amsterdam Public Health, Amsterdam UMC, Amsterdam UMC, Vrije Universiteit, Amsterdam, Amsterdam, 1081 HL, the Netherlands., Schraut KE; Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, EH16 4TJ, Scotland, UK., den Hoed M; The Beijer laboratory and Department of Immunology, Genetics and Pathology, Uppsala University and Science for Life Laboratory, Uppsala, 75237, Sweden., Degenhardt F; Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, 24105, Germany., Trompet S; Department of Internal Medicine, section Gerontology and Geriatrics, Leiden University Medical Center, Leiden, 2300 RC, the Netherlands.; Department of Cardiology, Leiden University Medical Center, Leiden, ZA, 2333, the Netherlands., van den Berg ME; Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015GD, the Netherlands., Pistis G; Institute of Genetics and Biomedic Research (IRGB), Italian National Research Council (CNR), Monserrato, (CA), 9042, Italy.; Center for Statistical Genetics, University of Michigan, Ann Arbor, 48109, USA., Tham YC; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, 169856, Singapore., Weiss S; Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, 17475, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, 17475, Germany., Sim XS; Saw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, 117549, Singapore., Li HL; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, 169856, Singapore., van der Most PJ; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, 9700 RB, The Netherlands., Nolte IM; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, 9700 RB, The Netherlands., Lyytikäinen LP; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, FI-33014, Finland.; Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, FI-33014, Finland.; Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB2 0SL, UK., Said MA; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, 9700RB, the Netherlands., Witte DR; Department of Public Health, Aarhus University, Aarhus C, 8000, Denmark., Iribarren C; Division of Research, Kaiser Permenente of Northern California, Oakland, 94612, USA.; The Scripps Research Institute, La Jolla, 10550, USA., Launer L; National Institute on Aging, Bethesda, MSC2292, USA., Ring SM; Bristol Medical School, Population Health Sciences, University of Bristol, Bristol, BS82BN, UK.; MRC Integrative Epidemiology, University of Bristol, Bristol, BS82BN, UK., de Vries PS; Department of Epidemiology, Human Genetics, and Environmental Sciences, University of Texas Health Science Center at Houston, School of Public Health, Houston, 77030, USA., Sever P; National Heart and Lung Institute, Imperial College London, London, W12 0NN, UK., Linneberg A; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, 2400, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark., Bottinger EP; The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, 10029, USA.; Department of Preventive Medicine, The Icahn School of Medicine at Mount Sinai, New York, 10029, USA., Padmanabhan S; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, G12 8TA, UK., Psaty BM; Departments of Medicine, Epidemiology and Health Systems and Population Health, University of Washington, Seattle, 98195, USA., Sotoodehnia N; Medicine and Epidemiology, University of Washington, Seattle, 98195, USA., Kolcic I; Department of Public Health, University of Split School of Medicine, Split, 21000, Croatia.; Algebra LAB, Algebra University College, Zagreb, 10000, Croatia., Arnar DO; deCODE genetics / Amgen Inc., Reykjavik, 102, Iceland.; Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, 101, Iceland.; Department of Medicine, Landspitali-The National University Hospital of Iceland, Reykjavik, 101, Iceland., Gudbjartsson DF; deCODE genetics / Amgen Inc., Reykjavik, 102, Iceland.; School of Engineering and Natural Sciences, University of Iceland, Reykjavik, 101, Iceland., Holm H; deCODE genetics / Amgen Inc., Reykjavik, 102, Iceland., Balkau B; Centre for Research in Epidemiology and Population Health, Institut national de la santé et de la recherche médicale, Villejuif, 94800, France.; UMRS 1018, University Versailles Saint-Quentin-en-Yvelines, Versailles, 78035, France.; UMRS 1018, University Paris Sud, Villejuif, 94807, France., Silva CT; Genetic Epidemiology Unit, Dept. of Epidemiology, Erasmus University Medical Center, Rotterdam, 3000CA, Netherlands., Newton-Cheh CH; Cardiology Section, Massachusetts general hospital,, Boston, 02130, USA., Nikus K; Department of Cardiology, Heart Center, Tampere University Hospital, Tampere, FI-33521, Finland.; Department of Cardiology, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, FI-33014, Finland., Salo P; Department of Health, unit of genetics and biomarkers, , National Institute for Health and Welfare, Finland, Helsinki, FI-00290, Finland.; Department of molecular medicine, University of Helsinki, Helsinki, FI-00290, Finland., Mohlke KL; Department of Genetics, University of North Carolina, Chapel Hill, NC, 27599, USA., Peyser PA; Department of Epidemiology, University of Michigan, Ann Arbor, MI, 48109, USA., Schunkert H; Department of Cardiology, Deutsches Herzzentrum München, Technische Universität München, Munich, 80636, Germany.; Deutsches Zentrum für Herz- und Kreislauferkrankungen (DZHK), Partner Site Munich Heart Alliance, Munich, 80636, Germany., Lorentzon M; Sahlgrenska Osteoporosis Centre, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, 41345, Sweden.; Region Västra Götaland, Geriatric Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Mölndal, 43180, Sweden.; Mary McKillop Institute for Health Research, Australian Catholic University, Melbourne, 3000, Australia., Lahti J; Department of Psychology and Logopedics, University of Helsinki, Helsinki, 00014, Finland., Rao DC; Division of Biostatistics, Washington University, St. Louis, MO, 63110, USA., Cornelis MC; Preventive Medicine, Northwestern University, Chicago, IL, 60611, USA., Faul JD; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, 48104, USA., Smith JA; Department of Epidemiology, University of Michigan, Ann Arbor, MI, 48109, USA.; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, 48104, USA., Stolarz-Skrzypek K; Department of Cardiology, Interventional Electrocardiology and Hypertension, Jagiellonian University Medical College, Kraków, 31-008, Poland., Bandinelli S; Geriatric Unit, Unità sanitaria locale Toscana Centro, Florence, 50142, Italy., Concas MP; Institute for Maternal and Child Health - IRCCS 'Burlo Garofolo', Trieste, 34137, Italy., Sinagra G; Cardiovascular Department, 'Ospedali Riuniti and University of Trieste', Trieste, 34149, Italy., Meitinger T; Institute of Human Genetics, Klinikum rechts der Isar, Technische Universität München, München, 81675, Germany.; Institute of Human Genetics, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, 85764, Germany., Waldenberger M; Research Unit Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, 85764, Germany.; Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, 85764, Germany.; German Centre for Cardiovascular Research (DZHK), partner site: Munich Heart Alliance, Munich, 80802, Germany., Sinner MF; German Centre for Cardiovascular Research (DZHK), partner site: Munich Heart Alliance, Munich, 80802, Germany.; Department of Cardiology, University Hospital, LMU Munich, Munich, 81377, Germany., Strauch K; Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center, Johannes Gutenberg University, Mainz, 55101, Germany.; Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, 85764, Germany.; Chair of Genetic Epidemiology, IBE, Faculty of Medicine, LMU Munich, Munich, 81377, Germany., Delgado GE; Vth Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, University of Heidelberg, Mannheim, 68167, Germany., Taylor KD; Pediatrics, The Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA, Torrance, 90502, USA.; Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, 90502, USA., Yao J; Pediatrics, The Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA, Torrance, 90502, USA.; Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, 90502, USA., Foco L; Institute for Biomedicine, Eurac Research, Bolzano, 39100, Italy., Melander O; Department of Internal Medicine, Clinical Sciences, Lund University and Skåne University Hospital, Malmo, 221 85, Sweden.; Lund University Diabetes Center, Lund University, Malmö, 221 85, Sweden., de Graaf J; Radboud university medical center, Nijmegen, 6500 HB, the Netherlands., de Mutsert R; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, 2300 RC, the Netherlands., de Geus EJC; Biological Psychology, EMGO+ Institute for Health and Care Research and Neuroscience Campus Amsterdam, VU University, Amsterdam, 1081 BT, the Netherlands., Johansson Å; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, 75108, Sweden., Joshi PK; Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, EH8 9AG, Scotland, UK., Lind L; Department of Medical Sciences, Cardiovascular Epidemiology, Uppsala University Hospital, Uppsala, 75237, Sweden., Franke A; Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, 24105, Germany., Macfarlane PW; Institute of Health and Wellbeing, Faculty of Medicine, University of Glasgow, Glasgow, G12 0XH, UK., Tarasov KV; Laboratory of Cardiovascular Sciences, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD, 21224, USA., Tan N; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, 169856, Singapore., Felix SB; DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, 17475, Germany.; Department of Internal Medicine B, University Medicine Greifswald, Greifswald, 17475, Germany., Tai ES; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, 169856, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore., Quek DQ; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, 169856, Singapore., Snieder H; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, 9700 RB, The Netherlands., Ormel J; Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, 9700 RB, The Netherlands., Ingelsson M; Department of Public Health and Caring Sciences, Molecular Geriatrics, Uppsala University, Uppsala, 75237, Sweden., Lindgren C; Genetic and Genomic Epidemiology Unit, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK., Morris AP; Genetic and Genomic Epidemiology Unit, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK., Raitakari OT; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, FI-20521, Finland.; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, FI-20521, Finland.; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, FI-20521, Finland., Hansen T; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medicine Science, University of Copenhagen, Copenhagen Ø, 2100, Denmark., Assimes T; Department of Medicine, Stanford University School of Medicine, Stanford, 94305, USA., Gudnason V; Faculty of Medicine, University of Iceland, Reykjavik, 101, Iceland.; Icelandic Heart Association, Kopavogur, 201, Iceland., Timpson NJ; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, BS8 2BN, UK.; Population Health Sciences, Bristol Medical School,, University of Bristol, Bristol, BS8 2BN, UK., Morrison AC; Department of Epidemiology, Human Genetics, and Environmental Sciences, University of Texas Health Science Center at Houston, School of Public Health, Houston, 77030, USA., Munroe PB; Clinical Pharmacology and Precision Medicine, William Harvey Research Institute, Barts and The London Faculty of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK.; NIHR Barts Biomedical Research Centre, Barts and The London Faculty of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK., Strachan DP; Population Health Research Institute, St George's, University of London, London, SW17 0RE, UK., Grarup N; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medicine Science, University of Copenhagen, Copenhagen Ø, 2100, Denmark., Loos RJF; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medicine Science, University of Copenhagen, Copenhagen Ø, 2100, Denmark.; The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, 10029, USA.; The Mindich Child Health and Development Institute, The Icahn School of Medicine at Mount Sinai, New York, 10029, USA., Heckbert SR; Department of Epidemiology, University of Washington, Seattle, 98195, USA., Vollenweider P; Department of Medicine, Internal Medicine, Lausanne University hospital, Lausanne, 1015, Switzerland., Hayward C; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, EH4 2XU, Scotland, UK., Stefansson K; deCODE genetics / Amgen Inc., Reykjavik, 102, Iceland.; Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, 101, Iceland., Froguel P; Department of Metabolism, Imperial College London, London, W12 0HS, UK.; Inserm/CNRS UMR 1283/8199, Pasteur Institute of Lille, Lille University Hospital, EGID, Lille, 59000, France.; University of Lille, Lille, 59000, France., Groop L; Lund University Diabetes Center, Department of Clinical Sciences, Lund University, Malmö, 20502, Sweden.; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, 00290, Finland., Wareham NJ; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK., van Duijn CM; Genetic Epidemiology Unit, Dept. of Epidemiology, Erasmus University Medical Center, Rotterdam, 3000CA, Netherlands., Feitosa MF; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, 63108-2212, Campus Box 8506, USA., O'Donnell CJ; Cardiology Section, VA Boston Healthcare System, Harvard Medical School, Boston, MA, 02132, USA., Kähönen M; Department of Clinical Physiology, Tampere University Hospital, Tampere, FI-33521, Finland.; Department of Clinical Physiology, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, FI-33521, Finland., Perola M; Department of Health, unit of genetics and biomarkers, , National Institute for Health and Welfare, Finland, Helsinki, FI-00290, Finland.; Department of molecular medicine, University of Helsinki, Helsinki, FI-00290, Finland., Boehnke M; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, 48109, USA., Kardia SLR; Department of Epidemiology, University of Michigan, Ann Arbor, MI, 48109, USA., Erdmann J; Institute for Cardiogenetics, University of Lübeck, Lübeck, 23562, Germany., Palmer CNA; Division of Population Health and Genomics, School of Medicine, University of Dundee, Dundee, DD1 9SY, UK., Ohlsson C; Sahlgrenska Osteoporosis Centre, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, 41345, Sweden.; Department of Drug Treatment, Sahlgrenska University Hospital, Gothenburg, 41345, Sweden., Porteous DJ; Centre for Genomic and Experimental Medicine, Institute of Genetics & Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK., Eriksson JG; Department of General practice and primary care, University of Helsinki, Helsinki, 00014, Finland.; Department of Obstetrics and Gynecology, National University of Singapore, Singapore, 119228, Singapore.; Public health Research Program, Folkhalsan Research Center, Helsinki, 000250, Finland., Bouchard C; Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, 70808, USA., Moebus S; Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, University Duisburg-Essen, Essen, 45122, Germany.; Centre for Urban Epidemiology, University Hospital of Essen, University Duisburg-Essen, Essen, 45122, Germany., Kraft P; Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, 02112, USA., Weir DR; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, 48104, USA., Cusi D; Unit of Biomedicine, Bio4Dreams-Business Nursery for Life Sciences, Milano, 20121, Italy.; Institute of Biomedical Technologies, National Research Council of Italy, Segrate, (MI), 20090, Italy., Ferrucci L; Longitudinal Study Section, National Institute on Aging, Baltimore, 21224, USA., Ulivi S; Institute for Maternal and Child Health - IRCCS 'Burlo Garofolo', Trieste, 34137, Italy., Girotto G; Institute for Maternal and Child Health - IRCCS 'Burlo Garofolo', Trieste, 34137, Italy.; Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, 34149, Italy., Correa A; Jackson Heart Study, University of Mississippi Medical Center, Jackson, 39216, USA., Kääb S; German Centre for Cardiovascular Research (DZHK), partner site: Munich Heart Alliance, Munich, 80802, Germany.; Department of Cardiology, University Hospital, LMU Munich, Munich, 81377, Germany., Peters A; Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, 85764, Germany.; German Centre for Cardiovascular Research (DZHK), partner site: Munich Heart Alliance, Munich, 80802, Germany.; Chair of Epidemiology, Institute for Medical Information Processing, Biometry and Epidemiology, Ludwig-Maximilians-Universität München, Munich, 81377, Germany., Chambers JC; Department of Epidemiology and Biostatistics, Imperial College London, London, W2 1PG, UK.; Department of Cardiology, Ealing Hospital, London North West University Healthcare NHS Trust, Middlesex, UB1 3HW, UK.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, 308232, Singapore., Kooner JS; Department of Cardiology, Ealing Hospital, London North West University Healthcare NHS Trust, Middlesex, UB1 3HW, UK.; National Heart and Lung Institute, Imperial College London, London, W12 0NN, UK.; Imperial College Healthcare NHS Trust, Imperial College London, London, W12 0HS, UK., März W; Vth Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, University of Heidelberg, Mannheim, 68167, Germany.; Synlab Academy, Synlab Holding Deutschland GmbH, Mannheim, 68161, Germany., Rotter JI; Pediatrics, The Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA, Torrance, 90502, USA.; Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, 90502, USA., Hicks AA; Institute for Biomedicine, Eurac Research, Bolzano, 39100, Italy., Smith JG; Department of Cardiology, Clinical Sciences, Lund University and Skåne University Hospital, Lund, 221 85, Sweden.; Wallenberg Center for Molecular Medicine and Lund University Diabetes Center, Lund University, Lund, 221 84, Sweden.; The Wallenberg Laboratory/Department of Molecular and Clinical Medicine, Institute of Medicine, Gothenburg University and the Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, 413 45, Sweden., Kiemeney LALM; Radboud university medical center, Nijmegen, 6500 HB, the Netherlands., Mook-Kanamori DO; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, 2300 RC, the Netherlands.; Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, 2300 RC, the Netherlands., Penninx BWJH; Department of Psychiatry, Amsterdam Public Health, Amsterdam UMC, Amsterdam UMC, Vrije Universiteit, Amsterdam, Amsterdam, 1081 HL, the Netherlands., Gyllensten U; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, 75108, Sweden., Wilson JF; Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, EH8 9AG, Scotland, UK.; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, EH4 2XU, Scotland, UK., Burgess S; MRC Biostatistics Unit, University of Cambridge, Cambridge, CB2 0SR, UK., Sundström J; Department of Medical Sciences, Cardiovascular Epidemiology, Uppsala University Hospital, Uppsala, 75237, Sweden., Lieb W; Institute of Epidemiology and Biobank PopGen, Kiel University, Kiel, 24105, Germany., Jukema JW; Department of Cardiology, Leiden University Medical Center, Leiden, ZA, 2333, the Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, ZA, 2333, the Netherlands.; Netherlands Heart Institute, Utrecht, 3511 EP, the Netherlands., Eijgelsheim M; Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015GD, the Netherlands.; Department of Nephrology, University Medical Center Groningen, Groningen, 9700RB, the Netherlands., Lakatta ELM; Laboratory of Cardiovascular Sciences, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD, 21224, USA., Cheng CY; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, 169856, Singapore.; Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, 169857, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119228, Singapore., Dörr M; DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, 17475, Germany.; Department of Internal Medicine B, University Medicine Greifswald, Greifswald, 17475, Germany., Wong TY; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, 169856, Singapore.; Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, 169857, Singapore.; Tsinghua Medicine, Tsinghua University, Beijing, 100084, China., Sabanayagam C; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, 169856, Singapore.; Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, 169857, Singapore., Oldehinkel AJ; Interdisciplinary Center Psychopathology and Emotion Regulation, University of Groningen, University Medical Center Groningen, Groningen, 9700 RB, The Netherlands., Riese H; Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, 9700 RB, The Netherlands., Lehtimäki T; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, FI-33014, Finland.; Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, FI-33014, Finland., Verweij N; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, 9700RB, the Netherlands., van der Harst P; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, 9700RB, the Netherlands. P.vanderHarst@umcutrecht.nl.; Department of Cardiology, University medical Center Utrecht, Utrecht, 3584 Cx, the Netherlands. P.vanderHarst@umcutrecht.nl.; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, 9700RB, the Netherlands. P.vanderHarst@umcutrecht.nl.

Publikováno v: Nature communications [Nat Commun] 2023 Aug 02; Vol. 14 (1), pp. 4646. Date of Electronic Publication: 2023 Aug 02.

Genome-wide meta-analyses reveal novel loci for verbal short-term memory and learning.

Autor: Lahti J; Department of Psychology and Logopedics, University of Helsinki, Helsinki, Finland. jari.lahti@helsinki.fi.; Turku Institute of Advanced Studies, University of Turku, Turku, Finland. jari.lahti@helsinki.fi., Tuominen S; Department of Psychology and Logopedics, University of Helsinki, Helsinki, Finland., Yang Q; Department of Biostatistics, Boston University, Boston, MA, USA., Pergola G; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA.; Department of Basic Medical Science, Neuroscience, and Sense Organs, University of Bari Aldo Moro, Bari, Italy., Ahmad S; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands., Amin N; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands., Armstrong NJ; Department of Mathematics and Statistics, Murdoch University, Murdoch, WA, Australia., Beiser A; Department of Biostatistics, Boston University, Boston, MA, USA.; Framingham Heart Study, Framingham, MA, USA., Bey K; Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany.; German Center for Neurodegenerative Diseases, Bonn, Germany., Bis JC; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Boerwinkle E; Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA., Bressler J; Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA., Campbell A; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.; Usher Institute, University of Edinburgh, Edinburgh, UK., Campbell H; Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK., Chen Q; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA., Corley J; Department of Psychology, Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK., Cox SR; Department of Psychology, Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK., Davies G; Department of Psychology, Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK., De Jager PL; Center for Translational and Computational Neuroimmunology, Columbia University Medical Center, New York, NY, USA., Derks EM; Translational Neurogenomics Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia., Faul JD; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA., Fitzpatrick AL; Department of Family Medicine, University of Washington, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Department of Global Health, University of Washington, Seattle, WA, USA., Fohner AE; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Institute of Public Health Genetics, University of Washington, Seattle, WA, USA., Ford I; Robertson Center for Biostatistics, University of Glasgow, Glasgow, UK., Fornage M; McGovern Medical School, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA., Gerring Z; Translational Neurogenomics Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia., Grabe HJ; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.; German Center for Neurodegenerative Diseases, Greifswald, Germany., Grodstein F; Channing Laboratory, Brigham and Women's Hospital, Boston, MA, USA.; Harvard School of Public Health, Boston, MA, USA., Gudnason V; Icelandic Heart Assocation, Kopavogur, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Simonsick E; Translational Gerontology Branch, National Institute on Aging, Intramural Research Program, National Institutes of Health, Baltimore, MD, USA., Holliday EG; School of Medicine and Public Health, University of Newcastle, Callaghan, NSW, Australia., Joshi PK; Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK.; Institute of Social and Preventive Medicine, University of Lausanne, Lausanne, Switzerland., Kajantie E; National Institute for Health and Welfare, Helsinki and Oulu, Oulu, Finland.; Hospital for Children and Adolescents, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.; PEDEGO Research Unit, MRC Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland., Kaprio J; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.; Department of Public Health, University of Helsinki, Helsinki, Finland., Karell P; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland., Kleineidam L; German Center for Neurodegenerative Diseases, Bonn, Germany.; Department for Neurodegenerative Diseases and Geriatric Psychiatry, University of Bonn, Bonn, Germany., Knol MJ; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands., Kochan NA; Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.; Neuropsychiatric Institute, Prince of Wales Hospital, Sydney, NSW, Australia., Kwok JB; Brain and Mind Centre, The University of Sydney, Sydney, NSW, Australia.; School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia., Leber M; Department of Psychiatry, University of Cologne, Cologne, Germany., Lam M; Psychiatry Research, Zucker Hillside Hospital, Glen Oaks, NY, USA.; Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA., Lee T; Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.; Neuropsychiatric Institute, Prince of Wales Hospital, Sydney, NSW, Australia., Li S; Department of Biostatistics, Boston University, Boston, MA, USA., Loukola A; Helsinki Biobank, University of Helsinki Central Hospital, Helsinki, Finland., Luck T; Department of Economic and Social Sciences & Institute of Social Medicine, Rehabilitation Sciences and Healthcare Research, University of Applied Sciences Nordhausen, Nordhausen, Germany.; University of Leipzig, Leipzig, Germany.; LIFE Leipzig Research Center for Civilization Diseases, Leipzig, Germany., Marioni RE; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK., Mather KA; Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.; Sunnybrook Health Sciences Centre, University of Toronto, Randwick, NSW, Australia., Medland S; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia., Mirza SS; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.; Department of Neurology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada., Nalls MA; Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA.; Data Tecnica International, Glen Echo, MD, USA., Nho K; Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA.; Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, IN, USA.; Indiana Alzheimer Disease Center, Indiana University School of Medicine, Indianapolis, IN, USA., O'Donnell A; Department of Biostatistics, Boston University, Boston, MA, USA.; Framingham Heart Study, Framingham, MA, USA., Oldmeadow C; Clinical Research Design, IT and Statistical Support Unit, Hunter Medical Research Institute, New Lambton, NSW, Australia., Painter J; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia., Pattie A; Department of Psychology, Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK., Reppermund S; Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.; Department of Developmental Disability Neuropsychiatry, School of Psychiatry, University of New South Wales, Sydney, NSW, Australia., Risacher SL; Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA.; Indiana Alzheimer Disease Center, Indiana University School of Medicine, Indianapolis, IN, USA., Rose RJ; Department of Psychological & Brain Sciences, Indiana University Bloomington, Bloomington, IN, USA., Sadashivaiah V; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA., Scholz M; Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.; LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany., Satizabal CL; Framingham Heart Study, Framingham, MA, USA.; Department of Neurology, Boston University, Boston, MA, USA.; Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX, USA., Schofield PW; Neuropsychiatry Service, Hunter New England Local Health District, Charlestown, NSW, Australia., Schraut KE; Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK.; Centre for Cardiovascular Sciences, Queen's Medical Research Institute, Royal Infirmary of Edinburgh, University of Edinburgh, Edinburgh, UK., Scott RJ; School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW, Australia.; Hunter Medical Research Institute, New Lambton, NSW, Australia., Simino J; Department of Data Science, University of Mississippi Medical Center, Jackson, MS, USA., Smith AV; Icelandic Heart Assocation, Kopavogur, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Smith JA; Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA.; Institute of Social Research, Survey Research Center, University of Michigan, Ann Arbor, MI, USA., Stott DJ; Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK., Surakka I; Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA., Teumer A; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany., Thalamuthu A; Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia., Trompet S; Section of Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands., Turner ST; Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA., van der Lee SJ; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.; Department of Neurology and Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands., Villringer A; Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.; Day Clinic for Cognitive Neurology, University Hospital Leipzig, Leipzig, Germany., Völker U; Interfaculty Institute for Genetics and Functional Genomics, Department Functional Genomics, University Medicine Greifswald, Greifswald, Germany., Wilson RS; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA., Wittfeld K; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.; German Center for Neurodegenerative Diseases, Greifswald, Germany., Vuoksimaa E; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland., Xia R; Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA., Yaffe K; Department of Psychiatry, University of California, San Francisco, CA, USA., Yu L; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA., Zare H; Department of Cell Systems & Anatomy, The University of Texas Health Science Center, San Antonio, TX, USA.; Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas, San Antonio, TX, USA.; University of Texas Health Sciences Center, Houston, NA, US., Zhao W; Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA., Ames D; National Ageing Research Institute, Parkville, Melbourne, VIC, Australia.; University of Melbourne, Academic Unit for Psychiatry of Old Age, St George's Hospital, Melbourne, VIC, Australia., Attia J; School of Medicine and Public Health, University of Newcastle, Callaghan, NSW, Australia.; Clinical Research Design, IT and Statistical Support Unit, Hunter Medical Research Institute, New Lambton, NSW, Australia., Bennett DA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA., Brodaty H; Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.; Dementia Collaborative Research Centre, University of New South Wales, Sydney, NSW, Australia., Chasman DI; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Goldman AL; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA., Hayward C; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK., Ikram MA; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands., Jukema JW; Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands., Kardia SLR; Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA., Lencz T; Hofstra Northwell School of Medicine, Hempstead, NY, USA., Loeffler M; Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.; LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany., Mattay VS; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA.; Food and Drug Administration, Washington, DC, USA., Palotie A; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.; Analytic and Translational Genetics Unit, Department of Medicine, Department of Neurology and Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.; The Stanley Center for Psychiatric Research and Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Psaty BM; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.; Department of Epidemiology and Department of Health Services, University of Washington, Seattle, WA, USA.; Kaiser Permanente Washington Heath Research Institute, Seattle, WA, USA., Ramirez A; Department for Neurodegenerative Diseases and Geriatric Psychiatry, University of Bonn, Bonn, Germany.; Department of Psychiatry, University of Cologne, Cologne, Germany., Ridker PM; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Riedel-Heller SG; Institute of Social Medicine, Occupational Health and Public Health, University of Leipzig, Leipzig, Germany., Sachdev PS; Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.; Neuropsychiatric Institute, Prince of Wales Hospital, Sydney, NSW, Australia., Saykin AJ; Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA.; Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, IN, USA.; Indiana Alzheimer Disease Center, Indiana University School of Medicine, Indianapolis, IN, USA., Scherer M; Institute of Primary Medical Care, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Schofield PR; School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia.; Neuroscience Research Australia, Randwick, NSW, Australia., Sidney S; Kaiser Permanente Northern California, Division of Research, Oakland, CA, USA., Starr JM; Department of Psychology, Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.; Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, UK., Trollor J; Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.; Department of Developmental Disability Neuropsychiatry, School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia., Ulrich W; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA., Wagner M; German Center for Neurodegenerative Diseases, Bonn, Germany.; Department for Neurodegenerative Diseases and Geriatric Psychiatry, University of Bonn, Bonn, Germany., Weir DR; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA., Wilson JF; Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK.; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK., Wright MJ; Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia.; Centre for Advanced Imaging, The University of Queensland, Brisbane, QLD, Australia., Weinberger DR; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA.; Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Debette S; Inserm, Bordeaux Population Health Research Center, team VINTAGE, UMR 1219, University of Bordeaux, Bordeaux, France.; Bordeaux University Hospital (CHU Bordeaux), Department of Neurology, Bordeaux, France., Eriksson JG; Folkhälsan Research Center, Helsinki, Finland.; Department of General Practice and Primary Health Care, University of Helsinki, and Helsinki University Hospital, University of Helsinki, Helsinki, Finland.; Department of Obstetrics & Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Helsinki, Singapore., Mosley TH Jr; Department of Medicine, Division of Geriatrics, University of Mississippi Medical Center, Jackson, MS, USA., Launer LJ; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, National Institutes of Health, Bethesda, MD, USA., van Duijn CM; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.; Department of Public Health, Oxford University, Oxford, UK., Deary IJ; Department of Psychology, Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK., Seshadri S; Framingham Heart Study, Framingham, MA, USA.; Department of Neurology, Boston University, Boston, MA, USA.; Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX, USA., Räikkönen K; Department of Psychology and Logopedics, University of Helsinki, Helsinki, Finland.

Publikováno v: Molecular psychiatry [Mol Psychiatry] 2022 Nov; Vol. 27 (11), pp. 4419-4431. Date of Electronic Publication: 2022 Aug 16.

A multi-omics study of circulating phospholipid markers of blood pressure.

Autor: Liu J; Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, the Netherlands. jun.liu@ndph.ox.ac.uk.; Nuffield Department of Population Health, University of Oxford, Oxford, UK. jun.liu@ndph.ox.ac.uk., de Vries PS; Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.; Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, Human Genetics Center, University of Texas Health Science Center at Houston, Houston, USA., Del Greco M F; Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano, Italy., Johansson Å; Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Schraut KE; Centre for Cardiovascular Sciences, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, Scotland, UK.; Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland, UK., Hayward C; Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, Western General Hospital, University of Edinburgh, Edinburgh, Scotland, UK., van Dijk KW; Department of Human Genetics, Leiden University Medical Centre, Leiden, the Netherlands.; Division of Endocrinology, Department of Internal Medicine, Leiden University Medical Center, Leiden, the Netherlands., Franco OH; Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.; Institute of Social and Preventive Medicine (ISPM), University of Bern, Bern, Switzerland., Hicks AA; Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano, Italy., Vitart V; Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, Western General Hospital, University of Edinburgh, Edinburgh, Scotland, UK., Rudan I; Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland, UK., Campbell H; Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland, UK., Polašek O; Department of Public Health, School of Medicine, University of Split, Split, Croatia.; Algebra University College, Ilica 242, Zagreb, Croatia., Pramstaller PP; Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano, Italy., Wilson JF; Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland, UK.; Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, Western General Hospital, University of Edinburgh, Edinburgh, Scotland, UK., Gyllensten U; Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden., van Duijn CM; Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.; Nuffield Department of Population Health, University of Oxford, Oxford, UK., Dehghan A; Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK., Demirkan A; Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.; Section of Statistical Multi-Omics, Department of Clinical and Experimental Research, University of Surrey, Guildford, Surrey, UK.; Department of Genetics, University Medical Center Groningen, Groningen, the Netherlands.

Publikováno v: Scientific reports [Sci Rep] 2022 Jan 12; Vol. 12 (1), pp. 574. Date of Electronic Publication: 2022 Jan 12.

The trans-ancestral genomic architecture of glycemic traits.

Autor: Chen J; Exeter Centre of Excellence for Diabetes Research (EXCEED), Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK.; Department of Human Genetics, Wellcome Sanger Institute, Cambridge, UK., Spracklen CN; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA.; Department of Biostatistics and Epidemiology, University of Massachusetts, Amherst, MA, USA., Marenne G; Department of Human Genetics, Wellcome Sanger Institute, Cambridge, UK.; Inserm, Univ Brest, EFS, UMR 1078, GGB, Brest, France., Varshney A; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA., Corbin LJ; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Department of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Luan J; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Willems SM; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Wu Y; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA., Zhang X; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.; Department of Biostatistics, School of Public Health, Shandong University, Jinan, China., Horikoshi M; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Laboratory for Genomics of Diabetes and Metabolism, RIKEN Centre for Integrative Medical Sciences, Yokohama, Japan., Boutin TS; Medical Research Council Human Genetics Unit, Institute for Genetics and Molecular Medicine, Edinburgh, UK., Mägi R; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia., Waage J; COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark., Li-Gao R; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands., Chan KHK; Department of Epidemiology, Brown University School of Public Health, Brown University, Providence, RI, USA.; Department of Biomedical Sciences, City University of Hong Kong, Hong Kong SAR, China.; Department of Electrical Engineering, City University of Hong Kong, Hong Kong SAR, China., Yao J; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Anasanti MD; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK., Chu AY; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA., Claringbould A; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Heikkinen J; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK., Hong J; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Hottenga JJ; Department of Biological Psychology, Faculty of Behaviour and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.; Amsterdam Public Health Research Institute, Amsterdam University Medical Center, Amsterdam, the Netherlands., Huo S; CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China., Kaakinen MA; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.; Section of Statistical Multi-omics, Department of Clinical and Experimental Research, University of Surrey, Guildford, UK., Louie T; Department of Biostatistics, University of Washington, Seattle, WA, USA., März W; SYNLAB Academy, SYNLAB Holding Deutschland GmbH, Mannheim, Germany.; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University Graz, Graz, Austria.; Vth Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, Heidelberg University, Mannheim, Baden-Württemberg, Germany., Moreno-Macias H; Department of Economics, Metropolitan Autonomous University, Mexico City, Mexico., Ndungu A; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK., Nelson SC; Department of Biostatistics, University of Washington, Seattle, WA, USA., Nolte IM; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., North KE; CVD Genetic Epidemiology Computational Laboratory, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA., Raulerson CK; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA., Ray D; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Rohde R; CVD Genetic Epidemiology Computational Laboratory, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA., Rybin D; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Schurmann C; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; HPI Digital Health Center, Digital Health and Personalized Medicine, Hasso Plattner Institute, Potsdam, Germany., Sim X; Saw Swee Hock School of Public Health, National Univeristy of Singapore and National University Health System, Singapore, Singapore.; Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.; Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Southam L; Department of Human Genetics, Wellcome Sanger Institute, Cambridge, UK.; Institute of Translational Genomics, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany., Stewart ID; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Wang CA; School of Medicine and Public Health, College of Health, Medicine and Wellbeing, The University of Newcastle, Newcastle, New South Wales, Australia., Wang Y; CVD Genetic Epidemiology Computational Laboratory, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA., Wu P; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Zhang W; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.; Department of Cardiology, Ealing Hospital, London North West Healthcare NHS Trust, London, UK., Ahluwalia TS; COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.; Steno Diabetes Center Copenhagen, Gentofte, Denmark.; The Bioinformatics Centre, Department of Biology, University of Copenhagen, Copenhagen, Denmark., Appel EVR; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Bielak LF; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Brody JA; Department of Medicine, Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA., Burtt NP; Metabolism Program, Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA., Cabrera CP; Department of Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; NIHR Barts Cardiovascular Biomedical Research Centre, Queen Mary University of London, London, UK., Cade BE; Department of Medicine, Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA.; Department of Medicine, Sleep Medicine, Harvard Medical School, Boston, MA, USA., Chai JF; Saw Swee Hock School of Public Health, National Univeristy of Singapore and National University Health System, Singapore, Singapore., Chai X; Ocular Epidemiology, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Department of Ophthalmology, National University of Singapore and National University Health System, Singapore, Singapore., Chang LC; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Chen CH; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Chen BH; Department of Epidemiology, The Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla, CA, USA., Chitrala KN; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA., Chiu YF; Institute of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan., de Haan HG; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands., Delgado GE; Vth Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, Heidelberg University, Mannheim, Baden-Württemberg, Germany., Demirkan A; Section of Statistical Multi-omics, Department of Clinical and Experimental Research, University of Surrey, Guildford, UK.; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands., Duan Q; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA.; Department of Statistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Engmann J; Institute of Cardiovascular Science, University College London, London, UK., Fatumo SA; Uganda Medical Informatics Centre (UMIC), MRC/UVRI and London School of Hygiene & Tropical Medicine (Uganda Research Unit), Entebbe, Uganda.; London School of Hygiene & Tropical Medicine, London, UK.; H3Africa Bioinformatics Network (H3ABioNet) Node, Centre for Genomics Research and Innovation, NABDA/FMST, Abuja, Nigeria., Gayán J; Bioinfosol, Sevilla, Spain., Giulianini F; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA., Gong JH; Department of Epidemiology, Brown University School of Public Health, Brown University, Providence, RI, USA., Gustafsson S; Molecular Epidemiology and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Uppsala, Sweden., Hai Y; Department of Statistics, The University of Auckland, Science Center, Auckland, New Zealand., Hartwig FP; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil., He J; Department of Medicine, Epidemiology, Vanderbilt University Medical Center, Nashville, TN, USA., Heianza Y; Department of Epidemiology, Tulane University Obesity Research Center, Tulane University, New Orleans, LA, USA., Huang T; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China., Huerta-Chagoya A; Molecular Biology and Genomic Medicine Unit, National Council for Science and Technology, Mexico City, Mexico.; Molecular Biology and Genomic Medicine Unit, National Institute of Medical Sciences and Nutrition, Mexico City, Mexico., Hwang MY; Division of Genome Science, Department of Precision Medicine, National Institute of Health, Cheongju, South Korea., Jensen RA; Department of Medicine, Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA., Kawaguchi T; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., Kentistou KA; Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK.; Centre for Cardiovascular Sciences, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK., Kim YJ; Division of Genome Science, Department of Precision Medicine, National Institute of Health, Cheongju, South Korea., Kleber ME; Vth Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, Heidelberg University, Mannheim, Baden-Württemberg, Germany., Kooner IK; Department of Cardiology, Ealing Hospital, London North West Healthcare NHS Trust, London, UK., Lai S; Department of Epidemiology, Brown University School of Public Health, Brown University, Providence, RI, USA., Lange LA; Department of Medicine, Divison of Biomedical Informatics and Personalized Medicine, University of Colorado Anschutz Medical Campus, Denver, CO, USA., Langefeld CD; Department of Biostatistics and Data Science, Wake Forest School of Medicine, Winston-Salem, NC, USA., Lauzon M; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Li M; Department of Medicine, Division of Nephrology and Hypertension, University of Utah, Salt Lake City, UT, USA., Ligthart S; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands., Liu J; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.; Nuffield Department of Population Health, University of Oxford, Oxford, UK., Loh M; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore., Long J; Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, TN, USA., Lyssenko V; Department of Clinical Science, Center for Diabetes Research, University of Bergen, Bergen, Norway.; Department of Clinical Sciences, Lund University Diabetes Centre, Lund University, Malmo, Sweden., Mangino M; Department of Twin Research and Genetic Epidemiology, School of Life Course Sciences, King's College London, London, UK.; NIHR Biomedical Research Centre, Guy's and St Thomas' NHS Foundation Trust, London, UK., Marzi C; Institute of Epidemiology, Research Unit of Molecular Epidemiology, Helmholtz Zentrum München Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany., Montasser ME; Department of Medicine, Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD, USA., Nag A; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK., Nakatochi M; Public Health Informatics Unit, Department of Integrated Sciences, Nagoya University Graduate School of Medicine, Nagoya, Japan., Noce D; Institute for Biomedicine, Eurac Research, Bolzano, Italy., Noordam R; Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands., Pistis G; Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche (CNR), Monserrato, Italy., Preuss M; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Mindich Child Health and Development Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Raffield L; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA., Rasmussen-Torvik LJ; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Rich SS; Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.; Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA., Robertson NR; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK., Rueedi R; Department of Computational Biology, University of Lausanne, Lausanne, Switzerland.; Swiss Institute of Bioinformatics, Lausanne, Switzerland., Ryan K; Department of Medicine, Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD, USA., Sanna S; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.; Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche (CNR), Monserrato, Italy., Saxena R; Center for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA., Schraut KE; Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK.; Centre for Cardiovascular Sciences, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK., Sennblad B; Department of Cell and Molecular Biology, National Bioinformatics Infrastructure Sweden, Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Setoh K; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., Smith AV; Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.; Icelandic Heart Association, Kopavogur, Iceland., Sparsø T; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Strawbridge RJ; Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK.; Department of Medicine Solna, Cardiovascular Medicine, Karolinska Institutet, Stockholm, Sweden., Takeuchi F; National Center for Global Health and Medicine, Tokyo, Japan., Tan J; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Trompet S; Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands.; Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands., van den Akker E; Department of Biomedical Data Sciences, Molecular Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.; Department of Pattern Recognition and Bioinformatics, Delft University of Technology, Delft, the Netherlands.; Department of Biomedical Data Sciences, Leiden Computational Biology Center, Leiden University Medical Center, Leiden, the Netherlands., van der Most PJ; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Verweij N; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.; Genomics PLC, Oxford, UK., Vogel M; Center of Pediatric Research, University Children's Hospital Leipzig, University of Leipzig Medical Center, Leipzig, Germany., Wang H; Department of Medicine, Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA.; Department of Medicine, Sleep Medicine, Harvard Medical School, Boston, MA, USA., Wang C; Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore., Wang N; Department of Preventive Medicine, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA.; University of Southern California Diabetes and Obesity Research Institute, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA., Warren HR; Department of Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; NIHR Barts Cardiovascular Biomedical Research Centre, Queen Mary University of London, London, UK., Wen W; Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, TN, USA., Wilsgaard T; Department of Community Medicine, Faculty of Health Sciences, UIT the Arctic University of Norway, Tromsø, Norway., Wong A; MRC Unit for Lifelong Health and Ageing at University College London, London, UK., Wood AR; Exeter Centre of Excellence for Diabetes Research (EXCEED), Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK., Xie T; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Zafarmand MH; Department of Public Health, Amsterdam Public Health Research Institute, Amsterdam University Medical Center, Amsterdam, the Netherlands.; Department of Clinical Epidemiology, Biostatistics, and Bioinformatics, Amsterdam Public Health Research Institute, Amsterdam University Medical Center, Amsterdam, the Netherlands., Zhao JH; Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge, UK., Zhao W; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Amin N; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.; Nuffield Department of Population Health, University of Oxford, Oxford, UK., Arzumanyan Z; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Astrup A; Department of Nutrition, Exercise, and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark., Bakker SJL; Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Baldassarre D; Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy.; Centro Cardiologico Monzino, IRCCS, Milan, Italy., Beekman M; Department of Biomedical Data Sciences, Molecular Epidemiology, Leiden University Medical Center, Leiden, the Netherlands., Bergman RN; Diabetes and Obesity Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Bertoni A; Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA., Blüher M; Medical Department III-Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany., Bonnycastle LL; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institues of Health, Bethesda, MD, USA., Bornstein SR; Department for Prevention and Care of Diabetes, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany., Bowden DW; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA., Cai Q; Department of Medicine, Epidemiology, Vanderbilt University Medical Center, Nashville, TN, USA., Campbell A; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK.; Usher Institute, University of Edinburgh, Edinburgh, UK., Campbell H; Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK., Chang YC; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.; Graduate Institute of Medical Genomics and Proteomics, National Taiwan University, Taipei, Taiwan., de Geus EJC; Department of Biological Psychology, Faculty of Behaviour and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.; Amsterdam Public Health Research Institute, Amsterdam University Medical Center, Amsterdam, the Netherlands., Dehghan A; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands., Du S; Department of Nutrition, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA., Eiriksdottir G; Icelandic Heart Association, Kopavogur, Iceland., Farmaki AE; Department of Population Science and Experimental Medicine, Institute of Cardiovascular Science, University College London, London, UK.; Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University of Athens, Athens, Greece., Frånberg M; Department of Medicine Solna, Cardiovascular Medicine, Karolinska Institutet, Stockholm, Sweden., Fuchsberger C; Institute for Biomedicine, Eurac Research, Bolzano, Italy., Gao Y; Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China., Gjesing AP; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Goel A; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Han S; Division of Genome Science, Department of Precision Medicine, National Institute of Health, Cheongju, South Korea., Hartman CA; Department of Psychiatry, Interdisciplinary Center Psychopathy and Emotion Regulation, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Herder C; Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany.; Division of Endocrinology and Diabetology, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.; German Center for Diabetes Research (DZD), Düsseldorf, Germany., Hicks AA; Institute for Biomedicine, Eurac Research, Bolzano, Italy., Hsieh CH; Internal Medicine, Endocrine and Metabolism, Tri-Service General Hospital, Taipei, Taiwan.; School of Medicine, National Defense Medical Center, Taipei, Taiwan., Hsueh WA; Internal Medicine, Endocrinology, Diabetes and Metabolism, Diabetes and Metabolism Research Center, The Ohio State University Wexner Medical Center, Columbus, OH, USA., Ichihara S; Department of Environmental and Preventive Medicine, Jichi Medical University School of Medicine, Shimotsuke, Japan., Igase M; Department of Anti-aging Medicine, Ehime University Graduate School of Medicine, Toon, Japan., Ikram MA; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands., Johnson WC; Department of Biostatistics, University of Washington, Seattle, WA, USA., Jørgensen ME; Steno Diabetes Center Copenhagen, Gentofte, Denmark.; National Institute of Public Health, University of Southern Denmark, Odense, Denmark., Joshi PK; Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK., Kalyani RR; Department of Medicine, Endocrinology, Diabetes and Metabolism, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Kandeel FR; Clinical Diabetes, Endocrinology and Metabolism, Translational Research and Cellular Therapeutics, Beckman Research Institute of the City of Hope, Duarte, CA, USA., Katsuya T; Department of Clinical Gene Therapy, Osaka University Graduate School of Medicine, Suita, Japan.; Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita, Japan., Khor CC; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore., Kiess W; Center of Pediatric Research, University Children's Hospital Leipzig, University of Leipzig Medical Center, Leipzig, Germany., Kolcic I; Department of Public Health, University of Split School of Medicine, Split, Croatia., Kuulasmaa T; Institute of Biomedicine, Bioinformatics Center, Univeristy of Eastern Finland, Kuopio, Finland., Kuusisto J; Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland., Läll K; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia., Lam K; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Lawlor DA; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Department of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Lee NR; USC-Office of Population Studies Foundation, University of San Carlos, Cebu City, the Philippines.; Department of Anthropology, Sociology and History, University of San Carlos, Cebu City, the Philippines., Lemaitre RN; Department of Medicine, Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA., Li H; State Key Laboratory of Oncogene and Related Genes and Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China., Lin SY; Center for Geriatrics and Gerontology, Taichung Veterans General Hospital, Taichung, Taiwan.; National Defense Medical Center, National Yang-Ming University, Taipei, Taiwan., Lindström J; Diabetes Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland., Linneberg A; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Liu J; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore.; Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore., Lorenzo C; Department of Medicine, University of Texas Health Sciences Center, San Antonio, TX, USA., Matsubara T; Department of Internal Medicine, Aichi Gakuin University School of Dentistry, Nagoya, Japan., Matsuda F; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., Mingrone G; Department of Diabetes, Diabetes, and Nutritional Sciences, James Black Centre, King's College London, London, UK., Mooijaart S; Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands., Moon S; Division of Genome Science, Department of Precision Medicine, National Institute of Health, Cheongju, South Korea., Nabika T; Department of Functional Pathology, Shimane University School of Medicine, Izumo, Japan., Nadkarni GN; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Nadler JL; Department of Medicine and Pharmacology, New York Medical College School of Medicine, Valhalla, NY, USA., Nelis M; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia., Neville MJ; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Oxford NIHR Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Norris JM; Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Ohyagi Y; Department of Geriatric Medicine and Neurology, Ehime University Graduate School of Medicine, Toon, Japan., Peters A; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Institute of Epidemiology, Helmholtz Zentrum München Research Center for Environmental Health, Neuherberg, Germany.; Institute for Medical Information Processing, Biometry and Epidemiology, Ludwig-Maximilians University Munich, Munich, Germany., Peyser PA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Polasek O; Department of Public Health, University of Split School of Medicine, Split, Croatia.; Gen-Info, Zagreb, Croatia., Qi Q; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, New York, NY, USA., Raven D; Department of Psychiatry, Interdisciplinary Center Psychopathy and Emotion Regulation, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Reilly DF; Genetics and Pharmacogenomics, Merck Sharp & Dohme, Kenilworth, NJ, USA., Reiner A; Department of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Rivideneira F; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands., Roll K; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Rudan I; Centre for Global Health, The Usher Institute, University of Edinburgh, Edinburgh, UK., Sabanayagam C; Ocular Epidemiology, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore., Sandow K; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Sattar N; BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK., Schürmann A; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Department of Experimental Diabetology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany., Shi J; Department of Genetics, Shanghai-MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center at Shanghai (CHGC) and Shanghai Academy of Science & Technology (SAST), Shanghai, China., Stringham HM; Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.; Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Taylor KD; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Teslovich TM; Sarepta Therapeutics, Cambridge, MA, USA., Thuesen B; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark., Timmers PRHJ; Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK.; Medical Research Council Human Genetics Unit, Institute for Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Tremoli E; Centro Cardiologico Monzino, IRCCS, Milan, Italy., Tsai MY; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA., Uitterlinden A; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands., van Dam RM; Saw Swee Hock School of Public Health, National Univeristy of Singapore and National University Health System, Singapore, Singapore.; Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore.; Department of Nutrition, Harvard T. H. Chan School of Public Health, Boston, MA, USA., van Heemst D; Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands., van Hylckama Vlieg A; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands., van Vliet-Ostaptchouk JV; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Vangipurapu J; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland., Vestergaard H; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Medicine, Bornholms Hospital, Rønne, Denmark., Wang T; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, New York, NY, USA., Willems van Dijk K; Department of Internal Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, the Netherlands.; Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands.; Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands., Zemunik T; Department of Human Biology, University of Split School of Medicine, Split, Croatia., Abecasis GR; Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Adair LS; Department of Nutrition, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.; Carolina Population Center, University of North Carolina, Chapel Hill, NC, USA., Aguilar-Salinas CA; Department of Endocrinology and Metabolism, Instituto Nacional de Ciencias Medicas y Nutricion, Mexico City, Mexico.; Unidad de Investigación de Enfermedades Metabólicas, Instituto Nacional de Ciencias Médicas y Nutrición and Tec Salud, Mexico City, Mexico.; Instituto Tecnológico y de Estudios Superiores de Monterrey Tec Salud, Monterrey, Mexico., Alarcón-Riquelme ME; Department of Medical Genomics, Pfizer/University of Granada/Andalusian Government Center for Genomics and Oncological Research (GENYO), Granada, Spain.; Institute for Environmental Medicine, Chronic Inflammatory Diseases, Karolinska Institutet, Solna, Sweden., An P; Department of Genetics, Division of Statistical Genomics, Washington University School of Medicine, St Louis, MO, USA., Aviles-Santa L; Clinical and Health Services Research, National Institute on Minority Health and Health Disparities, Bethesda, MD, USA., Becker DM; Department of Medicine, General Internal Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Beilin LJ; Medical School, Royal Perth Hospital Unit, University of Western Australia, Perth, Western Australia, Australia., Bergmann S; Department of Computational Biology, University of Lausanne, Lausanne, Switzerland.; Swiss Institute of Bioinformatics, Lausanne, Switzerland.; Department of Integrative Biomedical Sciences, University of Cape Town, Cape Town, South Africa., Bisgaard H; COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark., Black C; Aberdeen Centre for Health Data Science, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, UK., Boehnke M; Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.; Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Boerwinkle E; Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA., Böhm BO; Division of Endocrinology and Diabetes, Graduate School of Molecular Endocrinology and Diabetes, University of Ulm, Ulm, Germany.; LKC School of Medicine, Nanyang Technological University, Singapore and Imperial College London, UK, Singapore, Singapore., Bønnelykke K; COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark., Boomsma DI; Department of Biological Psychology, Faculty of Behaviour and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.; Amsterdam Public Health Research Institute, Amsterdam University Medical Center, Amsterdam, the Netherlands., Bottinger EP; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Hasso Plattner Institute for Digital Health at Mount Sinai, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Digital Health Center, Hasso Plattner Institut, University Potsdam, Potsdam, Germany., Buchanan TA; University of Southern California Diabetes and Obesity Research Institute, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA.; Department of Medicine, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA.; Department of Physiology and Neuroscience, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA., Canouil M; INSERM UMR 1283/CNRS UMR 8199, European Institute for Diabetes (EGID), Université de Lille, Lille, France.; INSERM UMR 1283/CNRS UMR 8199, European Institute for Diabetes (EGID), Institut Pasteur de Lille, Lille, France., Caulfield MJ; Department of Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; NIHR Barts Cardiovascular Biomedical Research Centre, Queen Mary University of London, London, UK., Chambers JC; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.; Department of Cardiology, Ealing Hospital, London North West Healthcare NHS Trust, London, UK.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.; Imperial College Healthcare NHS Trust, Imperial College London, London, UK.; MRC-PHE Centre for Environment and Health, Imperial College London, London, UK., Chasman DI; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Chen YI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Cheng CY; Ocular Epidemiology, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore., Collins FS; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institues of Health, Bethesda, MD, USA., Correa A; Department of Medicine, Jackson Heart Study, University of Mississippi Medical Center, Jackson, MS, USA., Cucca F; Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche (CNR), Monserrato, Italy., de Silva HJ; Department of Medicine, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka., Dedoussis G; Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University of Athens, Kallithea, Greece., Elmståhl S; Department of Clinical Sciences, Lund University, Malmö, Sweden., Evans MK; Laboratory of Epidemiology and Population Sciences, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, MD, USA., Ferrannini E; CNR Institute of Clinical Physiology, Pisa, Italy., Ferrucci L; Intramural Research Program, National Institute of Aging, Baltimore, MD, USA., Florez JC; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.; Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Franks PW; Department of Clinical Sciences, Lund University Diabetes Centre, Lund University, Malmo, Sweden.; Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden., Frayling TM; Exeter Centre of Excellence for Diabetes Research (EXCEED), Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK., Froguel P; INSERM UMR 1283/CNRS UMR 8199, European Institute for Diabetes (EGID), Université de Lille, Lille, France.; INSERM UMR 1283/CNRS UMR 8199, European Institute for Diabetes (EGID), Institut Pasteur de Lille, Lille, France.; Department of Genomics of Common Disease, Imperial College London, London, UK., Gigante B; Department of Medicine, Cardiovascular Medicine, Karolinska Institutet, Stockholm, Sweden., Goodarzi MO; Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Gordon-Larsen P; Department of Nutrition, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA.; Carolina Population Center, University of North Carolina, Chapel Hill, NC, USA., Grallert H; Institute of Epidemiology, Research Unit of Molecular Epidemiology, Helmholtz Zentrum München Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany., Grarup N; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Grimsgaard S; Department of Community Medicine, Faculty of Health Sciences, UIT the Arctic University of Norway, Tromsø, Norway., Groop L; Diabetes Centre, Lund University, Lund, Sweden.; Finnish Institute of Molecular Medicine, Helsinki University, Helsinki, Finland., Gudnason V; Icelandic Heart Association, Kopavogur, Iceland.; Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland., Guo X; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Hamsten A; Department of Medicine Solna, Cardiovascular Medicine, Karolinska Institutet, Stockholm, Sweden., Hansen T; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Hayward C; Medical Research Council Human Genetics Unit, Institute for Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Heckbert SR; Department of Epidemiology, Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA., Horta BL; Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil., Huang W; Department of Genetics, Shanghai-MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center at Shanghai (CHGC) and Shanghai Academy of Science & Technology (SAST), Shanghai, China., Ingelsson E; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford University, Stanford, CA, USA., James PS; Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, USA., Jarvelin MR; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.; Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland.; Unit of Primary Health Care, Oulu Univerisity Hospital, OYS, Oulu, Finland.; Department of Life Sciences, College of Health and Life Sciences, Brunel University London, London, UK., Jonas JB; Department of Ophthalmology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; Beijing Institute of Ophthalmology, Beijing Ophthalmology and Visual Science Key Lab, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China.; Institute of Molecular and Clinical Ophthalmology Basel IOB, Basel, Switzerland., Jukema JW; Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.; Netherlands Heart Institute, Utrecht, the Netherlands., Kaleebu P; MRC/UVRI and LSHTM (Uganda Research Unit), Entebbe, Uganda., Kaplan R; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, New York, NY, USA.; Department of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Kardia SLR; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Kato N; National Center for Global Health and Medicine, Tokyo, Japan., Keinanen-Kiukaanniemi SM; Faculty of Medicine, Institute of Health Sciences, University of Oulu, Oulu, Finland.; Unit of General Practice, Oulu University Hospital, Oulu, Finland., Kim BJ; Division of Genome Science, Department of Precision Medicine, National Institute of Health, Cheongju, South Korea., Kivimaki M; Department of Epidemiology and Public Health, University College London, London, UK., Koistinen HA; Department of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland.; Department of Medicine, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.; Minerva Foundation Institute for Medical Research, Helsinki, Finland., Kooner JS; Department of Cardiology, Ealing Hospital, London North West Healthcare NHS Trust, London, UK.; Imperial College Healthcare NHS Trust, Imperial College London, London, UK.; MRC-PHE Centre for Environment and Health, Imperial College London, London, UK.; National Heart and Lung Institute, Imperial College London, London, UK., Körner A; Center of Pediatric Research, University Children's Hospital Leipzig, University of Leipzig Medical Center, Leipzig, Germany., Kovacs P; Medical Department III-Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany.; IFB Adiposity Diseases, University of Leipzig Medical Center, Leipzig, Germany., Kuh D; MRC Unit for Lifelong Health and Ageing at University College London, London, UK., Kumari M; Institute for Social and Economic Research, University of Essex, Colchester, UK., Kutalik Z; Swiss Institute of Bioinformatics, Lausanne, Switzerland.; University Institute of Primary Care and Public Health, Division of Biostatistics, University of Lausanne, Lausanne, Switzerland., Laakso M; Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland., Lakka TA; Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio, Finland.; Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland.; Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, Finland., Launer LJ; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA., Leander K; Institute of Environmental Medicine, Cardiovascular and Nutritional Epidemiology, Karolinska Institutet, Stockholm, Sweden., Li H; CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China., Lin X; CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China., Lind L; Department of Medical Sciences, University of Uppsala, Uppsala, Sweden., Lindgren C; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Big Data Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Nuffield Department of Women's and Reproductive Health, University of Oxford, Oxford, UK., Liu S; Department of Epidemiology, Brown University School of Public Health, Brown University, Providence, RI, USA., Loos RJF; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Mindich Child Health and Development Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Magnusson PKE; Department of Medical Epidemiology and Biostatistics and the Swedish Twin Registry, Karolinska Institutet, Stockholm, Sweden., Mahajan A; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Genentech, South San Francisco, CA, USA., Metspalu A; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia., Mook-Kanamori DO; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.; Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, the Netherlands., Mori TA; Medical School, Royal Perth Hospital Unit, University of Western Australia, Perth, Western Australia, Australia., Munroe PB; Department of Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; NIHR Barts Cardiovascular Biomedical Research Centre, Queen Mary University of London, London, UK., Njølstad I; Department of Community Medicine, Faculty of Health Sciences, UIT the Arctic University of Norway, Tromsø, Norway., O'Connell JR; Department of Medicine, Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD, USA., Oldehinkel AJ; Department of Psychiatry, Interdisciplinary Center Psychopathy and Emotion Regulation, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Ong KK; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Padmanabhan S; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK., Palmer CNA; Division of Population Health and Genomics, School of Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK., Palmer ND; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA., Pedersen O; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Pennell CE; School of Medicine and Public Health, College of Health, Medicine and Wellbeing, The University of Newcastle, Newcastle, New South Wales, Australia., Porteous DJ; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK.; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK., Pramstaller PP; Institute for Biomedicine, Eurac Research, Bolzano, Italy., Province MA; Department of Genetics, Division of Statistical Genomics, Washington University School of Medicine, St Louis, MO, USA., Psaty BM; Department of Medicine, Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.; Department of Epidemiology, Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.; Department of Health Services, Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA., Qi L; Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA., Raffel LJ; Department of Pediatrics, Genetic and Genomic Medicine, University of California, Irvine, Irvine, CA, USA., Rauramaa R; Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, Finland., Redline S; Department of Medicine, Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA.; Department of Medicine, Sleep Medicine, Harvard Medical School, Boston, MA, USA., Ridker PM; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Havard Medical School, Boston, MA, USA., Rosendaal FR; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands., Saaristo TE; Tampere, Finnish Diabetes Association, Tampere, Finland.; Pirkanmaa Hospital District, Tampere, Finland., Sandhu M; Department of Medicine, University of Cambridge, Cambridge, UK., Saramies J; South Karelia Central Hospital, Lappeenranta, Finland., Schneiderman N; Department of Psychology, University of Miami, Miami, FL, USA., Schwarz P; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Department for Prevention and Care of Diabetes, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.; Paul Langerhans Institute Dresden of the Helmholtz Center Munich, University Hospital and Faculty of Medicine, Dresden, Germany., Scott LJ; Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.; Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Selvin E; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Sever P; National Heart and Lung Institute, Imperial College London, London, UK., Shu XO; Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, TN, USA., Slagboom PE; Department of Biomedical Data Sciences, Molecular Epidemiology, Leiden University Medical Center, Leiden, the Netherlands., Small KS; Department of Twin Research and Genetic Epidemiology, School of Life Course Sciences, King's College London, London, UK., Smith BH; Division of Population Health and Genomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK., Snieder H; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Sofer T; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA., Sørensen TIA; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Department of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Public Health, Section of Epidemiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Spector TD; Department of Twin Research and Genetic Epidemiology, School of Life Course Sciences, King's College London, London, UK., Stanton A; Department of Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland., Steves CJ; Department of Twin Research and Genetic Epidemiology, School of Life Course Sciences, King's College London, London, UK.; Department of Ageing and Health, Guy's and St Thomas' NHS Foundation Trust, London, UK., Stumvoll M; Medical Department III-Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany., Sun L; CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China., Tabara Y; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., Tai ES; Saw Swee Hock School of Public Health, National Univeristy of Singapore and National University Health System, Singapore, Singapore.; Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore.; Cardiovascular and Metabolic Disease Signature Research Program, Duke-NUS Medical School, Singapore, Singapore., Timpson NJ; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Department of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Tönjes A; Medical Department III-Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany., Tuomilehto J; Department of Public Health Solutions, National Institute for Health and Welfare, Helsinki, Finland.; Department of Public Health, University of Helsinki, Helsinki, Finland.; Saudi Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia., Tusie T; Molecular Biology and Genomic Medicine Unit, National Institute of Medical Sciences and Nutrition, Mexico City, Mexico.; Department of Genomic Medicine and Environmental Toxicology, Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, Mexico City, Mexico., Uusitupa M; Department of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland., van der Harst P; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., van Duijn C; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.; Nuffield Department of Population Health, University of Oxford, Oxford, UK., Vitart V; Medical Research Council Human Genetics Unit, Institute for Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Vollenweider P; Department of Medicine, Internal Medicine, Lausanne University Hospital (CHUV), Lausanne, Switzerland., Vrijkotte TGM; Department of Public Health, Amsterdam Public Health Research Institute, Amsterdam University Medical Center, Amsterdam, the Netherlands., Wagenknecht LE; Department of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA., Walker M; Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Wang YX; Beijing Institute of Ophthalmology, Beijing Ophthalmology and Visual Science Key Lab, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China., Wareham NJ; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Watanabe RM; Department of Preventive Medicine, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA.; University of Southern California Diabetes and Obesity Research Institute, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA.; Department of Physiology and Neuroscience, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA., Watkins H; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Wei WB; Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology & Visual Sciences Key Lab, Beijing Tongren Hospital, Capital Medical University, Beijing, China., Wickremasinghe AR; Department of Public Health, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka., Willemsen G; Department of Biological Psychology, Faculty of Behaviour and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.; Amsterdam Public Health Research Institute, Amsterdam University Medical Center, Amsterdam, the Netherlands., Wilson JF; Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK.; Medical Research Council Human Genetics Unit, Institute for Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Wong TY; Ocular Epidemiology, Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore., Wu JY; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Xiang AH; Department of Research and Evaluation, Kaiser Permanente of Southern California, Pasadena, CA, USA., Yanek LR; Department of Medicine, General Internal Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Yengo L; Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland, Australia., Yokota M; Kurume University School of Medicine, Kurume, Japan., Zeggini E; Department of Human Genetics, Wellcome Sanger Institute, Cambridge, UK.; Institute of Translational Genomics, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.; TUM School of Medicine, Technical University of Munich and Klinikum Rechts der Isar, Munich, Germany., Zheng W; Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, TN, USA., Zonderman AB; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA., Rotter JI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Gloyn AL; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Oxford NIHR Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.; Department of Pediatrics, Division of Endocrinology, Stanford School of Medicine, Stanford, CA, USA., McCarthy MI; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Oxford NIHR Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Genentech, South San Francisco, CA, USA., Dupuis J; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Meigs JB; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Department of Medicine, Division of General Internal Medicine, Massachusetts General Hospital, Boston, MA, USA., Scott RA; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Prokopenko I; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.; Section of Statistical Multi-omics, Department of Clinical and Experimental Research, University of Surrey, Guildford, UK., Leong A; Harvard Medical School, Boston, MA, USA.; Department of Medicine, General Internal Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Diabetes Unit and Endocrine Unit, Massachusetts General Hospital, Boston, MA, USA., Liu CT; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Parker SCJ; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.; Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA., Mohlke KL; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA., Langenberg C; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Wheeler E; Department of Human Genetics, Wellcome Sanger Institute, Cambridge, UK.; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Morris AP; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Centre for Genetics and Genomics Versus Arthritis, Division of Musculoskeletal and Dermatological Sciences, The University of Manchester, Manchester, UK.; Centre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, The University of Manchester, Manchester, UK.; Department of Biostatistics, University of Liverpool, Liverpool, UK., Barroso I; Exeter Centre of Excellence for Diabetes Research (EXCEED), Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK. ines.barroso@exeter.ac.uk.; Department of Human Genetics, Wellcome Sanger Institute, Cambridge, UK. ines.barroso@exeter.ac.uk.; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK. ines.barroso@exeter.ac.uk.

Publikováno v: Nature genetics [Nat Genet] 2021 Jun; Vol. 53 (6), pp. 840-860. Date of Electronic Publication: 2021 May 31.

Novel Genetic Locus Influencing Retinal Venular Tortuosity Is Also Associated With Risk of Coronary Artery Disease.

Autor: Veluchamy A; From the Division of Population Health and Genomics (A.V., E.R.P., C.N.A.P., A.S.F.D.), University of Dundee, United Kingdom., Ballerini L; Ninewells Hospital and Medical School and VAMPIRE project, Computer Vision and Image Processing Group, School of Science and Engineering (Computing) (L.B., E.T.), University of Dundee, United Kingdom.; VAMPIRE project, Centre for Clinical Brain Sciences, Chancellor's Building, Royal Infirmary of Edinburgh, Scotland, United Kingdom (L.B., D.R., B.D., T.M.)., Vitart V; MRC Human Genetics Unit (V.V., C.H., J.F.W.), MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, United Kingdom., Schraut KE; Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Scotland, United Kingdom (K.E.S., M.K., H.C., P.K.J., J.F.W.).; Centre for Cardiovascular Science (K.E.S.), Queen's Medical Research Institute, University of Edinburgh, Royal Infirmary of Edinburgh, Scotland, United Kingdom., Kirin M; Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Scotland, United Kingdom (K.E.S., M.K., H.C., P.K.J., J.F.W.).; Department of Public Health, University of Split, School of Medicine, Croatia (M.K., O.P.)., Campbell H; Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Scotland, United Kingdom (K.E.S., M.K., H.C., P.K.J., J.F.W.)., Joshi PK; Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Scotland, United Kingdom (K.E.S., M.K., H.C., P.K.J., J.F.W.)., Relan D; VAMPIRE project, Centre for Clinical Brain Sciences, Chancellor's Building, Royal Infirmary of Edinburgh, Scotland, United Kingdom (L.B., D.R., B.D., T.M.).; Department of Computer Science, BML Munjal University, Gurgaon, Haryana, India (D.R.)., Harris S; Medical Genetics Section, Centre for Genomic and Experimental Medicine (S.H.), MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, United Kingdom.; Centre for Cognitive Ageing and Cognitive Epidemiology (S.H., I.J.D.), University of Edinburgh, United Kingdom.; Department of Psychology (S.H.), University of Edinburgh, United Kingdom., Brown E; Clinical Research Imaging Centre (E.B., S.S.V.), Queen's Medical Research Institute, University of Edinburgh, Royal Infirmary of Edinburgh, Scotland, United Kingdom., Vaidya SS; Clinical Research Imaging Centre (E.B., S.S.V.), Queen's Medical Research Institute, University of Edinburgh, Royal Infirmary of Edinburgh, Scotland, United Kingdom., Dhillon B; VAMPIRE project, Centre for Clinical Brain Sciences, Chancellor's Building, Royal Infirmary of Edinburgh, Scotland, United Kingdom (L.B., D.R., B.D., T.M.)., Zhou K; Renji Hospital, University of Chinese Academy of Sciences, Chongqing, China (K.Z.)., Pearson ER; From the Division of Population Health and Genomics (A.V., E.R.P., C.N.A.P., A.S.F.D.), University of Dundee, United Kingdom., Hayward C; MRC Human Genetics Unit (V.V., C.H., J.F.W.), MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, United Kingdom., Polasek O; Department of Public Health, University of Split, School of Medicine, Croatia (M.K., O.P.)., Deary IJ; Department of Psychology (I.J.D.), University of Edinburgh, United Kingdom.; Centre for Cognitive Ageing and Cognitive Epidemiology (S.H., I.J.D.), University of Edinburgh, United Kingdom., MacGillivray T; VAMPIRE project, Centre for Clinical Brain Sciences, Chancellor's Building, Royal Infirmary of Edinburgh, Scotland, United Kingdom (L.B., D.R., B.D., T.M.)., Wilson JF; MRC Human Genetics Unit (V.V., C.H., J.F.W.), MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, United Kingdom.; Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Scotland, United Kingdom (K.E.S., M.K., H.C., P.K.J., J.F.W.)., Trucco E; Ninewells Hospital and Medical School and VAMPIRE project, Computer Vision and Image Processing Group, School of Science and Engineering (Computing) (L.B., E.T.), University of Dundee, United Kingdom., Palmer CNA; From the Division of Population Health and Genomics (A.V., E.R.P., C.N.A.P., A.S.F.D.), University of Dundee, United Kingdom., Doney ASF; From the Division of Population Health and Genomics (A.V., E.R.P., C.N.A.P., A.S.F.D.), University of Dundee, United Kingdom.

Publikováno v: Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 2019 Dec; Vol. 39 (12), pp. 2542-2552. Date of Electronic Publication: 2019 Oct 10.