Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Schow, Steven R."'
Autor:
Songyuan Shi, Schow Steven R, Hugo O. Villar, Deborah K. Toavs, Kozlowski Michael R, Vara Prasad Manchem, Michael M. Wick, Wayne R. Spevak, Ronald A. Kohanski, Lum Robert T, Edgardo Laborde, Ira D. Goldfine, Cristina P. Cristobal
Publikováno v:
Diabetes. 50:824-830
Insulin resistance, an important feature of type 2 diabetes, is manifested as attenuated insulin receptor (IR) signaling in response to insulin binding. A drug that promotes the initiation of IR signaling by enhancing IR autophosphorylation should, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f103fbd5946f762ca4747a7b04943945
https://doi.org/10.2337/diabetes.50.4.824
https://doi.org/10.2337/diabetes.50.4.824
Autor:
Suresh S. Kerwar, Dov Shiffman, Eric E. Brooks, Nelson Marek G, Xingbo Wang, Xiaoming Zhang, Lum Robert T, Alison Joly, Michael M. Wick, Amy G. Horsma, Cheri Lynn Blum, Schow Steven R, Richard L. Mackman, Gavin Lee
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:2697-2702
The preparation of a series of 2,6,9-trisubstituted purines and the structure-activity data for the inhibition of cyclin dependent kinase, CDK2 are presented.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de14a037cd1d599c4d6180cb0a06c405
https://doi.org/10.1016/s0960-894x(97)10076-2
https://doi.org/10.1016/s0960-894x(97)10076-2
Autor:
F.L. Zhang, Suresh S. Kerwar, Walter C. Pickett, Michael M. Wick, Schow Steven R, C. Silverstrim
Publikováno v:
Analytical Biochemistry. 225:60-63
A new fluorescence assay for measuring the activity of geranylgeranyl transferase (type I) is described. It does not require the use of either radiolabeled geranylgeranyl diphosphate or the purified recombinant Ras protein substrate with the carboxy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4139f5f1d93f584f959926776b41af5b
https://doi.org/10.1006/abio.1995.1108
https://doi.org/10.1006/abio.1995.1108
Publikováno v:
Tetrahedron Letters. 35:7005-7008
Differentially protected meso-2,6-diaminopimelic acid, a component of bacterial cell walls, a biosynthetic precursor of L-lysine and a constituent of several synthetic immunostimulants, has been prepared stereospecifically from L-glutamic acid.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ebfaed1541a97c1967afbf57e31c8e9b
https://doi.org/10.1016/0040-4039(94)88210-x
https://doi.org/10.1016/0040-4039(94)88210-x
Autor:
Robert E. Babine, Nan Zhang, Schow Steven R, Michael M. Wick, Martin F. Semmelhack, Richard C. Hastings, Zhangbao Xu, Suresh S. Kerwar, Randal A. Byrn
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:583-588
A new class of nonamino acid derived HIV-1 protease inhibitors of structure 1 are described. Structure activity relationships are discussed in the context of a protein crystal complex.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0bb6ce564c09650352115bf59310367a
https://doi.org/10.1016/s0960-894x(01)80159-1
https://doi.org/10.1016/s0960-894x(01)80159-1
Autor:
Schow Steven R, Suresh S. Kerwar, Michael M. Wick, Robert E. Babine, Randal A. Byrn, Bernard Dean Johnson, Michael R. Jirousek, Parimal R. Desai, Richard C. Hastings, Nan Zhang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 3:1589-1594
Lead compound 1, obtained from a previously reported structure-assisted design approach, was optimized to 17 using a traditional medicinal chemistry approach.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ee3e52231abc7bfa4baa21dc2c5c201
https://doi.org/10.1016/s0960-894x(00)80023-2
https://doi.org/10.1016/s0960-894x(00)80023-2
Autor:
Randal A. Byrn, Wellington T. Casscles, Michael M. Wick, Robert E. Babine, Schow Steven R, Nan Zhang, Grace C. Hsu, Bernard Dean Johnson, Michael R. Jirousek, Allan Wissner, Richard C. Hastings, Michael P. Trova, Suresh S. Kerwar
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 3:1595-1600
A series of HIV-1 protease inhibitors was prepared and evaluated against the free enzyme for inhibition properties, and for their anti-viral properties in human T lymphoid cells infected with HIVIIIB. Compounds 12, and 19 are the most potent anti-vir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::630b1d618c83e49464c5909493120a75
https://doi.org/10.1016/s0960-894x(00)80024-4
https://doi.org/10.1016/s0960-894x(00)80024-4
Autor:
Michael M. Wick, Robert E. Babine, Schow Steven R, Adrian W-H. Cheung, Philip M. Sass, Michael R. Jirousek
Publikováno v:
Tetrahedron Letters. 34:3671-3674
A general synthetic route to indolizidine alkaloids which are structurally similar to castanospermine and swainsonine is described. The described route uses modified pentose sugars and chiral reagents to control the absolute configuration at each asy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::161007d7fd6693e811b780241f452416
https://doi.org/10.1016/s0040-4039(00)79197-0
https://doi.org/10.1016/s0040-4039(00)79197-0
Autor:
Michael M. Wick, Michael R. Jirousek, Philip M. Sass, Schow Steven R, Robert E. Babine, A. W.-H. Cheung
Publikováno v:
ChemInform. 24
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a90f0aa30dc9780217b72a2052837f0
https://doi.org/10.1002/chin.199342269
https://doi.org/10.1002/chin.199342269
Publikováno v:
ChemInform. 26
Differentially protected meso-2,6-diaminopimelic acid, a component of bacterial cell walls, a biosynthetic precursor of L-lysine and a constituent of several synthetic immunostimulants, has been prepared stereospecifically from L-glutamic acid.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::731ab3c66d084b6541546277dfe3e54f
https://doi.org/10.1002/chin.199508242
https://doi.org/10.1002/chin.199508242