Nonperturbative Fluorogenic Labeling of Immunophilins Enables the Wash-free Detection of Immunosuppressants.

Autor: Bertolini M; Centre for Inflammation Research, The University of Edinburgh, EH16 4UU Edinburgh, U.K.; IRR Chemistry Hub, Institute for Regeneration and Repair, The University of Edinburgh, EH16 4UU Edinburgh, U.K., Mendive-Tapia L; Centre for Inflammation Research, The University of Edinburgh, EH16 4UU Edinburgh, U.K.; IRR Chemistry Hub, Institute for Regeneration and Repair, The University of Edinburgh, EH16 4UU Edinburgh, U.K., Ghashghaei O; Laboratory of Medicinal Chemistry, Faculty of Pharmacy and Food Sciences and Institute of Biomedicine UB (IBUB), University of Barcelona, Catalunya, Spain 08007., Reese A; Centre for Inflammation Research, The University of Edinburgh, EH16 4UU Edinburgh, U.K.; IRR Chemistry Hub, Institute for Regeneration and Repair, The University of Edinburgh, EH16 4UU Edinburgh, U.K., Lochenie C; Centre for Inflammation Research, The University of Edinburgh, EH16 4UU Edinburgh, U.K.; IRR Chemistry Hub, Institute for Regeneration and Repair, The University of Edinburgh, EH16 4UU Edinburgh, U.K., Schoepf AM; Laboratory of Medicinal Chemistry, Faculty of Pharmacy and Food Sciences and Institute of Biomedicine UB (IBUB), University of Barcelona, Catalunya, Spain 08007., Sintes M; Laboratory of Medicinal Chemistry, Faculty of Pharmacy and Food Sciences and Institute of Biomedicine UB (IBUB), University of Barcelona, Catalunya, Spain 08007., Tokarczyk K; Concept Life Sciences Ltd, Edinburgh Bioquarter, Edinburgh EH16 4UX, U.K., Nare Z; Concept Life Sciences Ltd, Edinburgh Bioquarter, Edinburgh EH16 4UX, U.K., Scott AD; Concept Life Sciences Ltd, Edinburgh Bioquarter, Edinburgh EH16 4UX, U.K., Knight SR; Renal Transplant Unit, Queen Elizabeth Hospital, 1345 Govan Road, Glasgow G51 4TF, U.K., Aithal AR; School of Chemistry, University of East Anglia, Norwich NR4 7TJ, U.K., Sachdeva A; School of Chemistry, University of East Anglia, Norwich NR4 7TJ, U.K., Lavilla R; Laboratory of Medicinal Chemistry, Faculty of Pharmacy and Food Sciences and Institute of Biomedicine UB (IBUB), University of Barcelona, Catalunya, Spain 08007., Vendrell M; Centre for Inflammation Research, The University of Edinburgh, EH16 4UU Edinburgh, U.K.; IRR Chemistry Hub, Institute for Regeneration and Repair, The University of Edinburgh, EH16 4UU Edinburgh, U.K.

Publikováno v: ACS central science [ACS Cent Sci] 2024 Mar 18; Vol. 10 (5), pp. 969-977. Date of Electronic Publication: 2024 Mar 18 (Print Publication: 2024).

Charting the Chemical Reaction Space around a Multicomponent Combination: Controlled Access to a Diverse Set of Biologically Relevant Scaffolds.

Autor: Nadal Rodríguez P; Department of Medicinal Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona and Institute of Biomedicine UB (IBUB), Av. De Joan XXIII, 27-31, 08028, Barcelona, Spain., Ghashghaei O; Department of Medicinal Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona and Institute of Biomedicine UB (IBUB), Av. De Joan XXIII, 27-31, 08028, Barcelona, Spain., Schoepf AM; Department of Medicinal Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona and Institute of Biomedicine UB (IBUB), Av. De Joan XXIII, 27-31, 08028, Barcelona, Spain., Benson S; Centre for Inflammation Research, The University of Edinburgh, Edinburgh, UK., Vendrell M; Centre for Inflammation Research, The University of Edinburgh, Edinburgh, UK., Lavilla R; Department of Medicinal Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona and Institute of Biomedicine UB (IBUB), Av. De Joan XXIII, 27-31, 08028, Barcelona, Spain.

Publikováno v: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2023 Oct 09; Vol. 62 (41), pp. e202303889. Date of Electronic Publication: 2023 Jun 02.

Novel strategies to eradicate resistant cells in chronic myeloid leukemia.

Autor: Schoepf AM; Department of Pharmaceutical Chemistry, Institute of Pharmacy, CMBI - Center for Molecular Biosciences Innsbruck, University of Innsbruck, CCB - Centrum for Chemistry & Biomedicine, Innrain 80-82, 6020 Innsbruck, Austria., Gust R; Department of Pharmaceutical Chemistry, Institute of Pharmacy, CMBI - Center for Molecular Biosciences Innsbruck, University of Innsbruck, CCB - Centrum for Chemistry & Biomedicine, Innrain 80-82, 6020 Innsbruck, Austria.

Publikováno v: Future medicinal chemistry [Future Med Chem] 2020 Dec; Vol. 12 (23), pp. 2089-2092. Date of Electronic Publication: 2020 Nov 24.

Identification and development of non-cytotoxic cell death modulators: Impact of sartans and derivatives on PPARγ activation and on growth of imatinib-resistant chronic myelogenous leukemia cells.

Autor: Schoepf AM; Department of Pharmaceutical Chemistry, Institute of Pharmacy, CMBI - Center for Molecular Biosciences Innsbruck, University of Innsbruck, CCB - Centrum for Chemistry and Biomedicine, Innrain 80-82, 6020, Innsbruck, Austria., Salcher S; Tyrolean Cancer Research Institute, Innrain 66, 6020, Innsbruck, Austria; Department of Internal Medicine V, Medical University Innsbruck, Anichstraße 35, 6020, Innsbruck, Austria., Obexer P; Tyrolean Cancer Research Institute, Innrain 66, 6020, Innsbruck, Austria; Department of Pediatrics II, Medical University Innsbruck, Innrain 66, 6020, Innsbruck, Austria., Gust R; Department of Pharmaceutical Chemistry, Institute of Pharmacy, CMBI - Center for Molecular Biosciences Innsbruck, University of Innsbruck, CCB - Centrum for Chemistry and Biomedicine, Innrain 80-82, 6020, Innsbruck, Austria. Electronic address: ronald.gust@uibk.ac.at.

Publikováno v: European journal of medicinal chemistry [Eur J Med Chem] 2020 Jun 01; Vol. 195, pp. 112258. Date of Electronic Publication: 2020 Mar 26.