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Characterization of triptolide-induced hepatotoxicity by imaging and transcriptomics in a novel zebrafish model

Autor: Vliegenthart, Bastiaan, Wei, Chunmin, Buckley, Charlotte, Berends, Cécile, de Potter, Carmelita, Schneemann, Sarah, Del-Pozo, Jorge, Tucker, Carl, Mullins, John, Webb, David, Dear, James

Publikováno v: Vliegenthart, B, Wei, C, Buckley, C, Berends, C, de Potter, C, Schneemann, S, Del-Pozo, J, Tucker, C, Mullins, J, Webb, D & Dear, J 2017, ' Characterization of triptolide-induced hepatotoxicity by imaging and transcriptomics in a novel zebrafish model ', Toxicological Sciences, vol. 159, no. 2, pp. 380-391 . https://doi.org/10.1093/toxsci/kfx144

Triptolide is a vine extract used in traditional Chinese medicines and associated with hepatotoxicity. In vitro data suggest that inhibition of RNA synthesis may be the mechanism of toxicity. For studying drug-induced liver injury the zebrafish has e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3094::ed29b9ca36f6f8775b5d05b087856457
https://www.pure.ed.ac.uk/ws/files/41257052/kfx144.pdf

Characterization of Triptolide-Induced Hepatotoxicity by Imaging and Transcriptomics in a Novel Zebrafish Model.

Autor: Bastiaan Vliegenthart, Adriaan D., Chunmin Wei, Buckley, Charlotte, Berends, Cécile, de Potter, Carmelita M. J., Schneemann, Sarah, Del Pozo, Jorge, Tucker, Carl, Mullins, John J., Webb, David J., Dear, James W.

Publikováno v: Toxicological Sciences; Oct2017, Vol. 159 Issue 2, p380-391, 12p, 2 Charts, 6 Graphs