3D model for CAR-mediated cytotoxicity using patient-derived colorectal cancer organoids.

Autor: Schnalzger TE; Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt am Main, Germany.; University of Konstanz, Konstanz, Germany., de Groot MH; Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt am Main, Germany., Zhang C; Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt am Main, Germany.; German Cancer Consortium (DKTK), Partner Site Frankfurt/Mainz, Frankfurt am Main, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany., Mosa MH; Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt am Main, Germany.; German Cancer Consortium (DKTK), Partner Site Frankfurt/Mainz, Frankfurt am Main, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany.; Frankfurt Cancer Institute, Goethe University, Frankfurt, Germany., Michels BE; Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt am Main, Germany.; German Cancer Consortium (DKTK), Partner Site Frankfurt/Mainz, Frankfurt am Main, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany.; Frankfurt Cancer Institute, Goethe University, Frankfurt, Germany.; Faculty of Biological Sciences, Goethe University, Frankfurt, Germany., Röder J; Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt am Main, Germany.; Frankfurt Cancer Institute, Goethe University, Frankfurt, Germany., Darvishi T; Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt am Main, Germany.; German Cancer Consortium (DKTK), Partner Site Frankfurt/Mainz, Frankfurt am Main, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany., Wels WS; Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt am Main, Germany.; German Cancer Consortium (DKTK), Partner Site Frankfurt/Mainz, Frankfurt am Main, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany.; Frankfurt Cancer Institute, Goethe University, Frankfurt, Germany., Farin HF; Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt am Main, Germany farin@gsh.uni-frankfurt.de.; German Cancer Consortium (DKTK), Partner Site Frankfurt/Mainz, Frankfurt am Main, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany.; Frankfurt Cancer Institute, Goethe University, Frankfurt, Germany.

Publikováno v: The EMBO journal [EMBO J] 2019 Jun 17; Vol. 38 (12). Date of Electronic Publication: 2019 Apr 29.