Emodepside targets SLO-1 channels of Onchocerca ochengi and induces broad anthelmintic effects in a bovine model of onchocerciasis.

Autor: Bah GS; Institut de Recherche Agricole pour le Développement, Centre Régional de Wakwa, Ngaoundéré, Cameroun., Schneckener S; Bayer AG, Engineering & Technology, Applied Mathematics, Leverkusen, Germany., Hahnel SR; Bayer Animal Health GmbH, Drug Discovery & External Innovation, Monheim am Rhein, Germany., Bayang NH; Institut de Recherche Agricole pour le Développement, Centre Régional de Wakwa, Ngaoundéré, Cameroun., Fieseler H; Bayer Animal Health GmbH, Drug Discovery & External Innovation, Monheim am Rhein, Germany., Schmuck GM; Bayer Animal Health GmbH, Drug Discovery & External Innovation, Monheim am Rhein, Germany., Krebber R; Bayer AG, Crop Science Division, Research & Development-Regulatory Science-Human Safety-Residue Analysis, Monheim am Rhein, Germany., Sarr A; INVENesis Sarl, St-Blaise (NE), Switzerland., Terjung C; Bayer AG, Pharmaceuticals, DMPK, Wuppertal, Germany., Ngangyung HF; Institut de Recherche Agricole pour le Développement, Centre Régional de Wakwa, Ngaoundéré, Cameroun., Ekale DD; Institut de Recherche Agricole pour le Développement, Centre Régional de Wakwa, Ngaoundéré, Cameroun., Mfopit YM; Institut de Recherche Agricole pour le Développement, Centre Régional de Wakwa, Ngaoundéré, Cameroun., Rufener L; INVENesis Sarl, St-Blaise (NE), Switzerland., Graham-Brown J; Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, United Kingdom., Tanya VN; Institut de Recherche Agricole pour le Développement, Centre Régional de Wakwa, Ngaoundéré, Cameroun.; Cameroon Academy of Sciences, Yaoundé, Cameroon., Glenschek-Sieberth M; Bayer AG, Pharmaceuticals, Wuppertal, Germany., Kulke D; Bayer Animal Health GmbH, Drug Discovery & External Innovation, Monheim am Rhein, Germany., Makepeace BL; Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, United Kingdom.

Publikováno v: PLoS pathogens [PLoS Pathog] 2021 Jun 02; Vol. 17 (6), pp. e1009601. Date of Electronic Publication: 2021 Jun 02 (Print Publication: 2021).