Neurotrophic tyrosine receptor kinase gene fusions in adult and pediatric patients with solid tumors: a clinicogenomic biobank and record linkage study of expression frequency and patient characteristics from Finland.

Autor: Zhang W; Bayer US LLC, Whippany, NJ, USA., Schmitz AA; Bayer AG, Berlin, Germany., Kallionpää RE; Auria Biobank, University of Turku and Turku University Hospital, Turku, Finland., Perälä M; Auria Biobank, University of Turku and Turku University Hospital, Turku, Finland., Pitkänen N; Auria Biobank, University of Turku and Turku University Hospital, Turku, Finland., Tukiainen M; Auria Biobank, University of Turku and Turku University Hospital, Turku, Finland., Alanne E; Department of Oncology and Radiotherapy, Turku University Hospital, Turku, Finland; Western Finland Cancer Centre, Turku, Finland., Jöhrens K; Dresden University Hospital, Technical University Dresden, Dresden, Germany., Schulze-Rath R; Bayer AG, Berlin, Germany., Farahmand B; Bayer AB, Solna, Sweden., Zong J; Bayer US LLC, Whippany, NJ, USA. jihong.zong@bayer.com.

Publikováno v: Acta oncologica (Stockholm, Sweden) [Acta Oncol] 2024 Jul 05; Vol. 63, pp. 542-551. Date of Electronic Publication: 2024 Jul 05.

Prognosis and oncogenomic profiling of patients with tropomyosin receptor kinase fusion cancer in the 100,000 genomes project.

Autor: Bridgewater J; University College London Hospitals NHS Trust, London, United Kingdom; University College London Cancer Institute, London, United Kingdom. Electronic address: j.bridgewater@ucl.ac.uk., Jiao X; Bayer HealthCare Pharmaceuticals, Inc., Whippany, NJ, United States of America., Parimi M; Real World Solutions, IQVIA, London, United Kingdom., Flach C; Real World Solutions, IQVIA, London, United Kingdom., Stratford J; RTI International, Durham, NC, United States of America., Kamburov A; Bayer AG, Berlin, Germany., Schmitz AA; Bayer AG, Berlin, Germany., Zong J; Bayer HealthCare Pharmaceuticals, Inc., Whippany, NJ, United States of America., Reeves JA; Bayer HealthCare Pharmaceuticals, Inc., Whippany, NJ, United States of America., Keating K; Bayer HealthCare Pharmaceuticals, Inc., Whippany, NJ, United States of America., Bruno A; Bayer HealthCare Pharmaceuticals, Inc., Whippany, NJ, United States of America., Fellous M; Bayer HealthCare Pharmaceuticals, Inc., Basel, Switzerland., Pereira MB; Genomics England, London, United Kingdom., Bazhenova L; University of California San Diego Moores Cancer Center, San Diego, CA, United States of America.

Publikováno v: Cancer treatment and research communications [Cancer Treat Res Commun] 2022; Vol. 33, pp. 100623. Date of Electronic Publication: 2022 Aug 23.

The Impact of Cand1 in Prostate Cancer.

Autor: Eigentler A; Department of Urology, Medical University of Innsbruck, 6020 Innsbruck, Austria., Tymoszuk P; Department of Internal Medicine II, Laboratory for Immunotherapy, Medical University of Innsbruck, 6020 Innsbruck , Austria., Zwick J; Department of Urology, Medical University of Innsbruck, 6020 Innsbruck, Austria., Schmitz AA; Bayer AG, Research & Development, Pharmaceuticals, 13353 Berlin, Germany., Pircher A; Department of Internal Medicine V, Medical University of Innsbruck, 6020 Innsbruck, Austria., Kocher F; Department of Internal Medicine V, Medical University of Innsbruck, 6020 Innsbruck, Austria., Schlicker A; Bayer AG, Research & Development, Pharmaceuticals, 13353 Berlin, Germany., Lesche R; Bayer AG, Research & Development, Pharmaceuticals, 13353 Berlin, Germany., Schäfer G; Department of Pathology, Medical University of Innsbruck, 6020 Innsbruck, Austria., Theurl I; Department of Internal Medicine II, Laboratory for Immunotherapy, Medical University of Innsbruck, 6020 Innsbruck , Austria., Klocker H; Department of Urology, Medical University of Innsbruck, 6020 Innsbruck, Austria., Heidegger I; Department of Urology, Medical University of Innsbruck, 6020 Innsbruck, Austria.

Publikováno v: Cancers [Cancers (Basel)] 2020 Feb 12; Vol. 12 (2). Date of Electronic Publication: 2020 Feb 12.

Evidence for an alternative fatty acid desaturation pathway increasing cancer plasticity.

Autor: Vriens K; Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, Leuven, Belgium.; Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium., Christen S; Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, Leuven, Belgium.; Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium., Parik S; Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, Leuven, Belgium.; Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium.; Laboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, Belgium.; Myeloid Cell Immunology Laboratory, VIB Center for Inflammation Research, Brussels, Belgium., Broekaert D; Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, Leuven, Belgium.; Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium., Yoshinaga K; Tsukishima Foods Industry, Tokyo, Japan.; Cluster of Agricultural Sciences, Faculty of Food and Agricultural Sciences, Fukushima University, Fukushima, Japan., Talebi A; Laboratory of Lipid Metabolism and Cancer, Department of Oncology, Leuven Cancer Institute (LKI), Leuven, Belgium., Dehairs J; Laboratory of Lipid Metabolism and Cancer, Department of Oncology, Leuven Cancer Institute (LKI), Leuven, Belgium., Escalona-Noguero C; Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, Leuven, Belgium.; Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium., Schmieder R; Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, Leuven, Belgium.; Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium., Cornfield T; The Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Churchill Hospital, Oxford, UK., Charlton C; The Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Churchill Hospital, Oxford, UK., Romero-Pérez L; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany., Rossi M; Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, Leuven, Belgium.; Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium., Rinaldi G; Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, Leuven, Belgium.; Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium., Orth MF; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany., Boon R; Stem Cell Institute, Department of Development and Regeneration, KU Leuven, Leuven, Belgium., Kerstens A; VIB Bio Imaging Core and VIB-KU Leuven Center for Brain & Disease Research, KU Leuven, Leuven, Belgium.; Molecular Neurobiology, Department of Neuroscience, KU Leuven, Leuven, Belgium., Kwan SY; Department of Molecular and Cellular Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Faubert B; Children's Medical Center Research Institute, UT Southwestern, Dallas, TX, USA., Méndez-Lucas A; The Francis Crick Institute, London, UK., Kopitz CC; Bayer AG, Research & Development, Pharmaceuticals, Berlin, Germany., Chen T; Perlmutter Cancer Center, NYU Langone Medical Center, Smilow Research Center, New York, NY, USA., Fernandez-Garcia J; Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, Leuven, Belgium.; Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium., Duarte JAG; Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, Leuven, Belgium.; Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium., Schmitz AA; Bayer AG, Research & Development, Pharmaceuticals, Berlin, Germany., Steigemann P; Bayer AG, Research & Development, Pharmaceuticals, Berlin, Germany., Najimi M; Laboratory of Pediatric Hepatology and Cell Therapy, Institut de Recherche Expérimentale et Clinique (IREC), Université Catholique de Louvain and Cliniques Universitaires St Luc, Brussels, Belgium., Hägebarth A; Bayer AG, Research & Development, Pharmaceuticals, Berlin, Germany., Van Ginderachter JA; Laboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, Belgium.; Myeloid Cell Immunology Laboratory, VIB Center for Inflammation Research, Brussels, Belgium., Sokal E; Laboratory of Pediatric Hepatology and Cell Therapy, Institut de Recherche Expérimentale et Clinique (IREC), Université Catholique de Louvain and Cliniques Universitaires St Luc, Brussels, Belgium., Gotoh N; Department of Food Science and Technology, Tokyo University of Marine Science and Technology, Tokyo, Japan., Wong KK; Perlmutter Cancer Center, NYU Langone Medical Center, Smilow Research Center, New York, NY, USA., Verfaillie C; Stem Cell Institute, Department of Development and Regeneration, KU Leuven, Leuven, Belgium., Derua R; Laboratory of Protein Phosphorylation and Proteomics, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium., Munck S; VIB Bio Imaging Core and VIB-KU Leuven Center for Brain & Disease Research, KU Leuven, Leuven, Belgium.; Molecular Neurobiology, Department of Neuroscience, KU Leuven, Leuven, Belgium., Yuneva M; The Francis Crick Institute, London, UK., Beretta L; Department of Molecular and Cellular Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., DeBerardinis RJ; Children's Medical Center Research Institute, UT Southwestern, Dallas, TX, USA.; Howard Hughes Medical Institute, UT Southwestern Medical Center, Dallas, TX, USA., Swinnen JV; Laboratory of Lipid Metabolism and Cancer, Department of Oncology, Leuven Cancer Institute (LKI), Leuven, Belgium., Hodson L; The Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Churchill Hospital, Oxford, UK., Cassiman D; Department of Hepatology, KU Leuven, Leuven, Belgium.; Department of Chronic Diseases, Metabolism and Ageing, KU Leuven, Leuven, Belgium., Verslype C; Department of Hepatology, KU Leuven, Leuven, Belgium.; Department of Digestive Oncology, KU Leuven, Leuven, Belgium., Christian S; Bayer AG, Research & Development, Pharmaceuticals, Berlin, Germany., Grünewald S; Bayer AG, Research & Development, Pharmaceuticals, Berlin, Germany., Grünewald TGP; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.; Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.; German Cancer Consortium (DKTK), Partner site Munich, Munich, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany., Fendt SM; Laboratory of Cellular Metabolism and Metabolic Regulation, VIB-KU Leuven Center for Cancer Biology, VIB, Leuven, Belgium. sarah-maria.fendt@kuleuven.vib.be.; Laboratory of Cellular Metabolism and Metabolic Regulation, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), Leuven, Belgium. sarah-maria.fendt@kuleuven.vib.be.

Publikováno v: Nature [Nature] 2019 Feb; Vol. 566 (7744), pp. 403-406. Date of Electronic Publication: 2019 Feb 06.

Sharing pharma compounds with academia: experiences with providing vitamin D receptor ligands.

Autor: Schmitz AA; 1] Global Drug Discovery, Bayer HealthCare Pharmaceuticals, Muellerstrasse 178, 13342 Berlin, Germany. [2]., Hackethal S; 1] Global Drug Discovery, Bayer HealthCare Pharmaceuticals, Muellerstrasse 178, 13342 Berlin, Germany. [2]., Schulz A; Global Drug Discovery, Bayer HealthCare Pharmaceuticals, Muellerstrasse 178, 13342 Berlin, Germany., May E; Global Drug Discovery, Bayer HealthCare Pharmaceuticals, Muellerstrasse 178, 13342 Berlin, Germany., Steinmeyer A; Global Drug Discovery, Bayer HealthCare Pharmaceuticals, Muellerstrasse 178, 13342 Berlin, Germany., Zügel U; Global Drug Discovery, Bayer HealthCare Pharmaceuticals, Muellerstrasse 178, 13342 Berlin, Germany., Asadullah K; Global Drug Discovery, Bayer HealthCare Pharmaceuticals, Muellerstrasse 178, 13342 Berlin, Germany.

Publikováno v: Nature reviews. Drug discovery [Nat Rev Drug Discov] 2015 Apr; Vol. 14 (4), pp. 294. Date of Electronic Publication: 2015 Mar 06.