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mRNA-based influenza vaccine expands breadth of B cell response in humans.

Autor: Matz HC; Department of Pathology and Immunology, Washington University School of Medicine; St. Louis, MO 63110, USA., Yu TG; Thayer School of Engineering, Dartmouth College; Hanover, NH 03755, USA., Zhou JQ; Department of Pathology and Immunology, Washington University School of Medicine; St. Louis, MO 63110, USA., Peyton L; Quantitative Biomedical Sciences Program, Dartmouth College; Lebanon, NH 03756, USA., Madsen A; Influenza Centre, Department of Clinical Science, University of Bergen; 5021 Bergen, Norway.; Department of Microbiology, Haukeland University Hospital, 5009 Bergen, Norway., Han F; Department of Pathology and Immunology, Washington University School of Medicine; St. Louis, MO 63110, USA., Schmitz AJ; Department of Pathology and Immunology, Washington University School of Medicine; St. Louis, MO 63110, USA., Horvath SC; Department of Pathology and Immunology, Washington University School of Medicine; St. Louis, MO 63110, USA., Dixit K; Department of Pathology and Immunology, Washington University School of Medicine; St. Louis, MO 63110, USA., Keplinger HK; Department of Pathology and Immunology, Washington University School of Medicine; St. Louis, MO 63110, USA., Strnad BS; Mallinckrodt Institute of Radiology, Washington University School of Medicine; St Louis, MO 63110, USA., Hoegger MJ; Mallinckrodt Institute of Radiology, Washington University School of Medicine; St Louis, MO 63110, USA., Middleton WD; Mallinckrodt Institute of Radiology, Washington University School of Medicine; St Louis, MO 63110, USA., Klebert MK; Infectious Disease Clinical Research Unit, Washington University School of Medicine; St Louis, MO 63110, USA., Lin NH; Moderna, Inc.; Cambridge, MA 02142, USA., Nachbagauer R; Moderna, Inc.; Cambridge, MA 02142, USA., Paris R; Moderna, Inc.; Cambridge, MA 02142, USA., Turner JS; Department of Pathology and Immunology, Washington University School of Medicine; St. Louis, MO 63110, USA., Presti RM; Infectious Disease Clinical Research Unit, Washington University School of Medicine; St Louis, MO 63110, USA.; Division of Infectious Diseases, Department of Internal Medicine, Washington University School of Medicine; St Louis, MO 63110, USA.; Center for Vaccines and Immunity to Microbial Pathogens, Washington University School of Medicine; St. Louis, MO 63110, USA.; The Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine; St. Louis, MO 63110, USA., Lee J; Thayer School of Engineering, Dartmouth College; Hanover, NH 03755, USA.; Quantitative Biomedical Sciences Program, Dartmouth College; Lebanon, NH 03756, USA., Ellebedy AH; Department of Pathology and Immunology, Washington University School of Medicine; St. Louis, MO 63110, USA.; Center for Vaccines and Immunity to Microbial Pathogens, Washington University School of Medicine; St. Louis, MO 63110, USA.; The Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine; St. Louis, MO 63110, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Oct 13. Date of Electronic Publication: 2024 Oct 13.

Influenza vaccination stimulates maturation of the human T follicular helper cell response.

Autor: Schattgen SA; Department of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, TN, USA., Turner JS; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Ghonim MA; Department of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, TN, USA., Crawford JC; Department of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, TN, USA., Schmitz AJ; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Kim H; Department of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, TN, USA., Zhou JQ; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Awad W; Department of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, TN, USA., Mettelman RC; Department of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, TN, USA., Kim W; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.; Department of Microbiology, Korea University College of Medicine, Seoul, Korea., McIntire KM; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Haile A; Clinical Trials Unit, Washington University School of Medicine, St. Louis, MO, USA., Klebert MK; Clinical Trials Unit, Washington University School of Medicine, St. Louis, MO, USA., Suessen T; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA., Middleton WD; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA., Teefey SA; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA., Presti RM; Division of Infectious Diseases, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO, USA., Ellebedy AH; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA. ellebedy@wustl.edu.; The Andrew M. and Jane M. Bursky Center for Human Immunology & Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO, USA. ellebedy@wustl.edu.; Center for Vaccines and Immunity to Microbial Pathogens, Washington University School of Medicine, St. Louis, MO, USA. ellebedy@wustl.edu., Thomas PG; Department of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, TN, USA. paul.thomas@stjude.org.

Publikováno v: Nature immunology [Nat Immunol] 2024 Sep; Vol. 25 (9), pp. 1742-1753. Date of Electronic Publication: 2024 Aug 20.

Leveraging vaccination-induced protective antibodies to define conserved epitopes on influenza N2 neuraminidase.

Autor: Lei R; Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA., Kim W; Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA; Department of Microbiology, Korea University College of Medicine, Seoul 02841, Korea., Lv H; Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA; HKU-Pasteur Research Pole, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China., Mou Z; Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH 44106, USA., Scherm MJ; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Schmitz AJ; Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA., Turner JS; Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA., Tan TJC; Center for Biophysics and Quantitative Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA., Wang Y; Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA., Ouyang WO; Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA., Liang W; HKU-Pasteur Research Pole, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China., Rivera-Cardona J; Department of Microbiology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA., Teo C; Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA., Graham CS; Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA., Brooke CB; Department of Microbiology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA., Presti RM; Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA; Center for Vaccines and Immunity to Microbial Pathogens, Washington University School of Medicine, Saint Louis, MO 63110, USA; The Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, Saint Louis, MO 63110, USA., Mok CKP; The Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong SAR, China; Li Ka Shing Institute of Health Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China; S.H. Ho Research Centre for Infectious Diseases, The Chinese University of Hong Kong, Hong Kong SAR, China. Electronic address: kapunmok@cuhk.edu.hk., Krammer F; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Pathology, Molecular and Cell Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Center for Vaccine Research and Pandemic Preparedness (C-VARPP), Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: florian.krammer@mssm.edu., Dai X; Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH 44106, USA. Electronic address: xxd159@case.edu., Ellebedy AH; Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA; Center for Vaccines and Immunity to Microbial Pathogens, Washington University School of Medicine, Saint Louis, MO 63110, USA; The Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, Saint Louis, MO 63110, USA. Electronic address: ellebedy@wustl.edu., Wu NC; Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA; Center for Biophysics and Quantitative Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA; Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA; Carle Illinois College of Medicine, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA. Electronic address: nicwu@illinois.edu.

Publikováno v: Immunity [Immunity] 2023 Nov 14; Vol. 56 (11), pp. 2621-2634.e6.

Human anti-N1 monoclonal antibodies elicited by pandemic H1N1 virus infection broadly inhibit HxN1 viruses in vitro and in vivo.

Autor: Hansen L; Influenza Centre, Department of Clinical Science, University of Bergen, Bergen, Norway; Department of Microbiology, Haukeland University Hospital, Bergen, Norway., McMahon M; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Turner HL; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA., Zhu X; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA., Turner JS; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Ozorowski G; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA., Stadlbauer D; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Vahokoski J; Influenza Centre, Department of Clinical Science, University of Bergen, Bergen, Norway; National Advisory Unit for Tropical Infectious Diseases, Haukeland University Hospital, Bergen, Norway., Schmitz AJ; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Rizk AA; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Alsoussi WB; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Strohmeier S; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Yu W; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA., Choreño-Parra JA; Laboratory of Immunobiology and Genetics, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, Mexico; Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Mexico City, Mexico., Jiménez-Alvarez L; Laboratory of Immunobiology and Genetics, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, Mexico., Cruz-Lagunas A; Laboratory of Immunobiology and Genetics, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, Mexico., Zúñiga J; Laboratory of Immunobiology and Genetics, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, Mexico; Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Mexico City, Mexico., Mudd PA; Department of Emergency Medicine, Washington University School of Medicine, St. Louis, MO, USA., Cox RJ; Influenza Centre, Department of Clinical Science, University of Bergen, Bergen, Norway; Department of Microbiology, Haukeland University Hospital, Bergen, Norway., Wilson IA; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA; Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA. Electronic address: wilson@scripps.edu., Ward AB; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA. Electronic address: andrew@scripps.edu., Ellebedy AH; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA; Center for Vaccines and Immunity to Microbial Pathogens, Washington University School of Medicine, St. Louis, MO, USA; The Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO, USA. Electronic address: ellebedy@wustl.edu., Krammer F; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Pathology, Molecular and Cell-based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Center for Vaccine Research and Pandemic Preparedness (C-VaRPP), Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address: florian.krammer@mssm.edu.

Publikováno v: Immunity [Immunity] 2023 Aug 08; Vol. 56 (8), pp. 1927-1938.e8. Date of Electronic Publication: 2023 Jul 27.